ID A0A0W0G3Q7_9AGAR Unreviewed; 2333 AA.
AC A0A0W0G3Q7;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE RecName: Full=Ketosynthase family 3 (KS3) domain-containing protein {ECO:0000259|PROSITE:PS52004};
GN ORFNames=WG66_4194 {ECO:0000313|EMBL:KTB43225.1};
OS Moniliophthora roreri.
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Agaricomycetes;
OC Agaricomycetidae; Agaricales; Marasmiineae; Marasmiaceae; Moniliophthora.
OX NCBI_TaxID=221103 {ECO:0000313|EMBL:KTB43225.1, ECO:0000313|Proteomes:UP000054988};
RN [1] {ECO:0000313|EMBL:KTB43225.1, ECO:0000313|Proteomes:UP000054988}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MCA 2952 {ECO:0000313|EMBL:KTB43225.1,
RC ECO:0000313|Proteomes:UP000054988};
RA Aime M.C., Diaz-Valderrama J.R., Kijpornyongpan T., Phillips-Mora W.;
RT "Draft genome sequence of Moniliophthora roreri, the causal agent of frosty
RT pod rot of cacao.";
RL Submitted (DEC-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- PATHWAY: Secondary metabolite biosynthesis.
CC {ECO:0000256|ARBA:ARBA00005179}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KTB43225.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; LATX01001222; KTB43225.1; -; Genomic_DNA.
DR SMR; A0A0W0G3Q7; -.
DR eggNOG; KOG1178; Eukaryota.
DR eggNOG; KOG1202; Eukaryota.
DR Proteomes; UP000054988; Unassembled WGS sequence.
DR GO; GO:0004315; F:3-oxoacyl-[acyl-carrier-protein] synthase activity; IEA:InterPro.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.
DR GO; GO:0044550; P:secondary metabolite biosynthetic process; IEA:UniProt.
DR CDD; cd00833; PKS; 1.
DR Gene3D; 3.30.70.3290; -; 1.
DR Gene3D; 3.40.47.10; -; 1.
DR Gene3D; 3.40.366.10; Malonyl-Coenzyme A Acyl Carrier Protein, domain 2; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 2.
DR Gene3D; 3.10.129.110; Polyketide synthase dehydratase; 1.
DR InterPro; IPR001227; Ac_transferase_dom_sf.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR014043; Acyl_transferase.
DR InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR InterPro; IPR013120; Far_NAD-bd.
DR InterPro; IPR018201; Ketoacyl_synth_AS.
DR InterPro; IPR014031; Ketoacyl_synth_C.
DR InterPro; IPR014030; Ketoacyl_synth_N.
DR InterPro; IPR016036; Malonyl_transacylase_ACP-bd.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR032821; PKS_assoc.
DR InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR InterPro; IPR042104; PKS_dehydratase_sf.
DR InterPro; IPR020807; PKS_DH.
DR InterPro; IPR049551; PKS_DH_C.
DR InterPro; IPR049552; PKS_DH_N.
DR InterPro; IPR013968; PKS_KR.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR016039; Thiolase-like.
DR PANTHER; PTHR43775; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR43775:SF37; FATTY ACID SYNTHASE; 1.
DR Pfam; PF00698; Acyl_transf_1; 1.
DR Pfam; PF16197; KAsynt_C_assoc; 1.
DR Pfam; PF00109; ketoacyl-synt; 1.
DR Pfam; PF02801; Ketoacyl-synt_C; 1.
DR Pfam; PF08659; KR; 1.
DR Pfam; PF07993; NAD_binding_4; 1.
DR Pfam; PF21089; PKS_DH_N; 1.
DR Pfam; PF00550; PP-binding; 1.
DR Pfam; PF14765; PS-DH; 1.
DR SMART; SM00827; PKS_AT; 1.
DR SMART; SM00826; PKS_DH; 1.
DR SMART; SM00822; PKS_KR; 1.
DR SMART; SM00825; PKS_KS; 1.
DR SUPFAM; SSF47336; ACP-like; 1.
DR SUPFAM; SSF52151; FabD/lysophospholipase-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 2.
DR SUPFAM; SSF55048; Probable ACP-binding domain of malonyl-CoA ACP transacylase; 1.
DR SUPFAM; SSF53901; Thiolase-like; 1.
DR PROSITE; PS00606; KS3_1; 1.
DR PROSITE; PS52004; KS3_2; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000054988};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 6..424
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
SQ SEQUENCE 2333 AA; 254614 MW; C3C751583A3292FF CRC64;
MACNPSGRTA VVGIACDLPS GSYSDRNLTY QEFFNFLQDR GEAYEEIPSD RLNIESWQGV
GLGHVQVRKG AFLKDIDKFD NLEFGISQND TSLMSAVTRK LIETCFLALL DSGIDYRGKN
VGCYTSGNSF DLSSVSDPDE YMTASFAGYP SMVANRVSYH LDLLGPSLPT DTACSSTVTA
LHLAVSAILN GDCEAAVVSG CQLNHRFMDW IQYSRGGILS DDGKCKPFDA SADGFGRGEA
CVAIVIKPLE AALRDGDHIY ATILSTAINN SGQAAPAGAP VAERQRDAMI EAYRRANMNP
KDVDYIELHA TGTAKGDPTE ANWAGEEFKR DGDVIVGSLK GNIGHTEIAS LLASLAKVLH
IFEHGIIPPN ANFVTPNPAI RWEEYRLRVP TEPLPLRTHD DRPSLISMAS SGIGGSNGHV
LLEGPPKSKA SLEPCSISQS LTLLVAGGLS PRTALAVGEQ AAEALSDPSC NRASLATVLG
RRSKQMAWRT FTIASSDSKP DLTFPSPVLS SRVARPIVFL FSGQGPQHKD MGRQLFSTFP
VFRQSIEEMD EVHKRVTGVS LIADYGLFTG KANMPETWPI SLILPSITIF QLALYELFLS
LGVRPDVVIG HSAGETAVLH ACGGAPKAMA VELSIIRGQT FTAVEALGGT MAALSCSAEK
TEELIRLLLD ENQKEVVEIA CYNSPTDTAV AGHRSAIERL IEKAKEHDIL GRIIRTQVPI
HSSMMEACRE EYTQRLEDLF RRYPGPHTPS VMTYSTFTGE RFAESFEAEY FWKNTRGQVH
FTQAMKSLSD LGALTVIEIS PHPVLASYTS ALVDHSSVVL SSVKRPKTGQ SATEYRNLLE
LCGQLTVNGH NCINFAALNG TASLHARNAL PPYPFAKKQF PLYPDTPGVA KQFATRNGPL
NHKYLKINKD THPIIGEHVI RGEPIMPAAG FIETALEFGA TTLMNVEMRS ILSLSSDKPV
PVQVALDGCY WKVVSTSLGA KDGSHISTKT ERLHADGYLS FEPPTVGEPI DIPAIRSRCH
TVVSEGFYND HDGSGMGPRF RRLINLMYGD GECLASVNGL DDDLRSDGKF VLHPAVIDAC
IQASTFKPFQ GEYSPFVYYL PAGVQTVQLH QPSRPHCCPR FFYSYLKITE WNIGMLHHVS
RLAIIDETIA DSVLHDVILT DSTGIPFCTM KGFRIAKHRI TLPPNLSRAF DVAWRPLEQS
RNDAGKLFHP RSFVFNYHLG DEAELQWLLS GLNPSQTLDI WILASHGSHG SNVIGLLRAV
RREYPLWNFR AVLFPSAYPE ETWVQHLTGI PDSLSEEPEI MVSESGEYLV SRLEEVERHD
IPAKIVNNVD TIPEVSSHEV LVRVNTKHSQ NGSTVLVGTV TKPCDCGFPD GASVVGFAVG
SFHENVLAFP SHHLVQIPPR HAEAFARNSP QMLPFISAVL ALGPSTFRSL TYARSLKVLL
THADTPGGSA IKSIFQDHGI PLHEAVKDAQ LSELSQLGAG QFDVVISGYE EAPYNQILKT
LLKDGRGKLY VPSRLNDLVA GDPCLVQEAL QFVIAWLEEK PFHLAKDQHA LPVIDMVDQK
HSSITRVKYH ADRTYIILGG IGSLGLHIAL YLYEHGARHI VLTSRSGYKA ISRSQNRMLR
NMAAHLAKFK DLDLQYTAVD SLSKHAMTIL FQSLSFPLAG CFILTAVLDD STFLNISEES
FSRSRAAKVG VLDVLLETMD VSELDFLVAF SSVSGTIGNS GQANYGAANT SLEEAVRSIP
NAFSFICPGV VDSSLMLGTG ATEQARVLRT GIPWSMSAED MILWLDDSLK LFFEGKKVMK
YVPDLEWDIL AQVHGIPQLA RHLTTRTEDG DAGASGQADH KQIIREIVQQ TLNVPASDFE
DNIPLTSYGI DSISASRVAF LLRRFVDITQ IQLLADISLN DILQKMGDDS STRSAESSPQ
LQTIGKQVKV LGPSAMLESQ LADLSDLAGS MPAAKSARSA LDTVLVTGTT GALGCNILSQ
LLARDDVTHV FALNRGSPDK SAMDRQAHTF VSQGVPIILL SSPKLTVLEG DMSLPNFGLD
ISIHEELLER VTHVIHAAWK VNFGAPVSDF EDLIKGTTNL IRFCSTSNST LSFISTIGIY
LGMHSPSGLP EAPITRAEDA KLPGGYLESK WIAERLVQIQ SEDMNIRANV VRVGLITGGL
NGIWDSSHWL PTLVESGLHV GCLPEGDGVA SWIPIDLAAA AIIECHSTMN ETIHIVHPRP
VPWNTLIAPI AEDLQLPLVP VREWITRLEH MNEFSNSPRA RKIPAFALLD FYREGARNAA
AQASPESMGM LPSVASTKGT ASSVTLSNPE LPQLGISHVK AWLRYWKDIG FLQ
//
