ID A0A0W0SLI0_9GAMM Unreviewed; 398 AA.
AC A0A0W0SLI0;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Efflux protein {ECO:0000313|EMBL:KTC84129.1};
GN Name=lmxE {ECO:0000313|EMBL:KTC84129.1};
GN ORFNames=Lbru_1490 {ECO:0000313|EMBL:KTC84129.1};
OS Legionella brunensis.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Legionellales;
OC Legionellaceae; Legionella.
OX NCBI_TaxID=29422 {ECO:0000313|EMBL:KTC84129.1, ECO:0000313|Proteomes:UP000054742};
RN [1] {ECO:0000313|EMBL:KTC84129.1, ECO:0000313|Proteomes:UP000054742}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 43878 {ECO:0000313|EMBL:KTC84129.1,
RC ECO:0000313|Proteomes:UP000054742};
RA Burstein D., Amaro F., Zusman T., Lifshitz Z., Cohen O., Gilbert J.A.,
RA Pupko T., Shuman H.A., Segal G.;
RT "Genomic analysis of 38 Legionella species identifies large and diverse
RT effector repertoires.";
RL Submitted (NOV-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane
CC {ECO:0000256|ARBA:ARBA00004519}; Lipid-anchor
CC {ECO:0000256|ARBA:ARBA00004519}. Membrane
CC {ECO:0000256|ARBA:ARBA00004635}; Lipid-anchor
CC {ECO:0000256|ARBA:ARBA00004635}.
CC -!- SIMILARITY: Belongs to the membrane fusion protein (MFP) (TC 8.A.1)
CC family. {ECO:0000256|ARBA:ARBA00009477}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KTC84129.1}.
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DR EMBL; LNXV01000011; KTC84129.1; -; Genomic_DNA.
DR RefSeq; WP_058441561.1; NZ_LNXV01000011.1.
DR AlphaFoldDB; A0A0W0SLI0; -.
DR STRING; 29422.Lbru_1490; -.
DR PATRIC; fig|29422.6.peg.1577; -.
DR OrthoDB; 9800613at2; -.
DR Proteomes; UP000054742; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0042221; P:response to chemical; IEA:UniProt.
DR Gene3D; 2.40.30.170; -; 1.
DR Gene3D; 2.40.420.20; -; 1.
DR Gene3D; 2.40.50.100; -; 1.
DR Gene3D; 1.10.287.470; Helix hairpin bin; 1.
DR InterPro; IPR043602; CusB_dom_1.
DR InterPro; IPR032317; HlyD_D23.
DR InterPro; IPR006143; RND_pump_MFP.
DR NCBIfam; TIGR01730; RND_mfp; 1.
DR PANTHER; PTHR30158; ACRA/E-RELATED COMPONENT OF DRUG EFFLUX TRANSPORTER; 1.
DR PANTHER; PTHR30158:SF3; MULTIDRUG EFFLUX PUMP SUBUNIT ACRA-RELATED; 1.
DR Pfam; PF00529; CusB_dom_1; 1.
DR Pfam; PF16576; HlyD_D23; 1.
DR SUPFAM; SSF111369; HlyD-like secretion proteins; 1.
DR PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE 3: Inferred from homology;
KW Lipoprotein {ECO:0000256|ARBA:ARBA00023288};
KW Palmitate {ECO:0000256|ARBA:ARBA00023139};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 23..398
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5006912100"
FT DOMAIN 36..359
FT /note="Cation efflux system protein CusB"
FT /evidence="ECO:0000259|Pfam:PF00529"
FT DOMAIN 62..291
FT /note="RND efflux pump membrane fusion protein barrel-
FT sandwich"
FT /evidence="ECO:0000259|Pfam:PF16576"
SQ SEQUENCE 398 AA; 43508 MW; BC309FB8B0C2A7A9 CRC64;
MKKKSSVTNV VLVLLATLPL LFSCSDKKKQ SAEETPEVGV VTLKVEPFTF TVELPGRTRP
YRVAEVRPQV SGIILKRQFV EGSDVKEGQS LYQIDPAPYQ AAYDSAKGDL AKAQANAEIN
HLTVKRYKPL LSTNYVSHQD YDTAVANAKQ ADATVIAAEA ALEKARINLI YTKVISPISG
RIGKSSVTEG ALVTENQTTA LTSVHQLDPI YVDVTQSSKD FLRLRREYAS GFLKKNSSNI
VVELILEDGS LYSKTGILEF SDVTVDETTG SITVRAIFPN PHHELLPGMF VRARLKEGIK
EHAILAPQQG VTRNARGEAT ALIVDANGVV VLRKIEAIRA VGDKWLVTRG LNAGDKIIVS
GHMKVKSGMK VKSTEVTIEQ NKITIDEKMP ADKQQKGN
//
