ID A0A0W0U995_9GAMM Unreviewed; 383 AA.
AC A0A0W0U995;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE SubName: Full=Cystathionine beta-lyase {ECO:0000313|EMBL:KTD04363.1};
DE EC=2.5.1.48 {ECO:0000313|EMBL:KTD04363.1};
DE EC=4.4.1.8 {ECO:0000313|EMBL:SPX62842.1};
GN Name=metB {ECO:0000313|EMBL:KTD04363.1};
GN Synonyms=metC {ECO:0000313|EMBL:SPX62842.1};
GN ORFNames=Lfee_0190 {ECO:0000313|EMBL:KTD04363.1}, NCTC12022_03610
GN {ECO:0000313|EMBL:SPX62842.1};
OS Legionella feeleii.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Legionellales;
OC Legionellaceae; Legionella.
OX NCBI_TaxID=453 {ECO:0000313|EMBL:KTD04363.1, ECO:0000313|Proteomes:UP000054698};
RN [1] {ECO:0000313|EMBL:KTD04363.1, ECO:0000313|Proteomes:UP000054698}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=WO-44C {ECO:0000313|EMBL:KTD04363.1,
RC ECO:0000313|Proteomes:UP000054698};
RA Burstein D., Amaro F., Zusman T., Lifshitz Z., Cohen O., Gilbert J.A.,
RA Pupko T., Shuman H.A., Segal G.;
RT "Genomic analysis of 38 Legionella species identifies large and diverse
RT effector repertoires.";
RL Submitted (NOV-2015) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:SPX62842.1, ECO:0000313|Proteomes:UP000251942}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NCTC12022 {ECO:0000313|EMBL:SPX62842.1,
RC ECO:0000313|Proteomes:UP000251942};
RG Pathogen Informatics;
RA Doyle S.;
RL Submitted (JUN-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
CC Evidence={ECO:0000256|ARBA:ARBA00001933,
CC ECO:0000256|RuleBase:RU362118};
CC -!- SIMILARITY: Belongs to the trans-sulfuration enzymes family.
CC {ECO:0000256|ARBA:ARBA00009077, ECO:0000256|RuleBase:RU362118}.
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DR EMBL; LNYB01000008; KTD04363.1; -; Genomic_DNA.
DR EMBL; UASS01000040; SPX62842.1; -; Genomic_DNA.
DR RefSeq; WP_058443405.1; NZ_UASS01000040.1.
DR AlphaFoldDB; A0A0W0U995; -.
DR STRING; 453.Lfee_0190; -.
DR PATRIC; fig|453.4.peg.210; -.
DR OrthoDB; 9805807at2; -.
DR Proteomes; UP000054698; Unassembled WGS sequence.
DR Proteomes; UP000251942; Unassembled WGS sequence.
DR GO; GO:0004121; F:cystathionine beta-lyase activity; IEA:UniProtKB-EC.
DR GO; GO:0003962; F:cystathionine gamma-synthase activity; IEA:UniProtKB-EC.
DR GO; GO:0102028; F:cystathionine gamma-synthase activity (acts on O-phosphohomoserine); IEA:UniProtKB-EC.
DR GO; GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
DR GO; GO:0019346; P:transsulfuration; IEA:InterPro.
DR CDD; cd00614; CGS_like; 1.
DR Gene3D; 3.90.1150.10; Aspartate Aminotransferase, domain 1; 1.
DR Gene3D; 3.40.640.10; Type I PLP-dependent aspartate aminotransferase-like (Major domain); 1.
DR InterPro; IPR000277; Cys/Met-Metab_PyrdxlP-dep_enz.
DR InterPro; IPR015424; PyrdxlP-dep_Trfase.
DR InterPro; IPR015421; PyrdxlP-dep_Trfase_major.
DR InterPro; IPR015422; PyrdxlP-dep_Trfase_small.
DR PANTHER; PTHR11808:SF92; CYSTATHIONINE GAMMA-SYNTHASE; 1.
DR PANTHER; PTHR11808; TRANS-SULFURATION ENZYME FAMILY MEMBER; 1.
DR Pfam; PF01053; Cys_Met_Meta_PP; 1.
DR PIRSF; PIRSF001434; CGS; 1.
DR SUPFAM; SSF53383; PLP-dependent transferases; 1.
DR PROSITE; PS00868; CYS_MET_METAB_PP; 1.
PE 3: Inferred from homology;
KW Lyase {ECO:0000313|EMBL:KTD04363.1};
KW Pyridoxal phosphate {ECO:0000256|ARBA:ARBA00022898,
KW ECO:0000256|PIRSR:PIRSR001434-2};
KW Reference proteome {ECO:0000313|Proteomes:UP000054698};
KW Transferase {ECO:0000313|EMBL:KTD04363.1}.
FT REGION 1..22
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 199
FT /note="N6-(pyridoxal phosphate)lysine"
FT /evidence="ECO:0000256|PIRSR:PIRSR001434-2"
SQ SEQUENCE 383 AA; 41958 MW; CB9D7AA55B4DF4F6 CRC64;
MASTHFDTRA IHAGQEPDPS TGAVMTPIYA TSTYRQSAPG IHQGYEYSRT HNPTRTAYEG
CIASLESGQR GFAFASGMAA INTVIDLLDA GAHVIATDDL YGGTFRLFDK VKTRTSGLSF
SFVDMSDIKN IEAAIRPETR MIWLETPSNP MLKLANIREI AKLGKRRNLI TVADNTFATP
WIQRPLELGF DIVLHSATKY LNGHSDVISG VVVVGNTPEL ADKIAFLQNS CGAVAGPFDS
FLVLRSLKTL SLRMQRHCEN ALALANWLEK NPKISKVIYP GLVSHPQHFL AREQMHDFGG
MISMVINGDL DTAKRFLSRC ELFTLAESLG GVESLIEHPA IMTHASVPAE KRRALGIEDG
FIRLSVGIEH IDDLIADLNH ALS
//
