ID A0A0W0V7G3_9GAMM Unreviewed; 652 AA.
AC A0A0W0V7G3;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 27-MAR-2024, entry version 17.
DE SubName: Full=Acetyl-CoA synthetase {ECO:0000313|EMBL:KTD16046.1};
DE EC=6.2.1.1 {ECO:0000313|EMBL:KTD16046.1};
GN Name=acsA {ECO:0000313|EMBL:KTD16046.1};
GN ORFNames=Lisr_2193 {ECO:0000313|EMBL:KTD16046.1};
OS Legionella israelensis.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Legionellales;
OC Legionellaceae; Legionella.
OX NCBI_TaxID=454 {ECO:0000313|EMBL:KTD16046.1, ECO:0000313|Proteomes:UP000054761};
RN [1] {ECO:0000313|EMBL:KTD16046.1, ECO:0000313|Proteomes:UP000054761}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bercovier 4 {ECO:0000313|EMBL:KTD16046.1,
RC ECO:0000313|Proteomes:UP000054761};
RA Burstein D., Amaro F., Zusman T., Lifshitz Z., Cohen O., Gilbert J.A.,
RA Pupko T., Shuman H.A., Segal G.;
RT "Genomic analysis of 38 Legionella species identifies large and diverse
RT effector repertoires.";
RL Submitted (NOV-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KTD16046.1}.
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DR EMBL; LNYH01000126; KTD16046.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0W0V7G3; -.
DR STRING; 454.Lisr_2193; -.
DR PATRIC; fig|454.4.peg.2395; -.
DR Proteomes; UP000054761; Unassembled WGS sequence.
DR GO; GO:0003987; F:acetate-CoA ligase activity; IEA:UniProtKB-EC.
DR GO; GO:0030729; F:acetoacetate-CoA ligase activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0006629; P:lipid metabolic process; IEA:InterPro.
DR CDD; cd05943; AACS; 1.
DR Gene3D; 3.30.300.30; -; 1.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR InterPro; IPR005914; Acac_CoA_synth.
DR InterPro; IPR032387; ACAS_N.
DR InterPro; IPR025110; AMP-bd_C.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR NCBIfam; TIGR01217; ac_ac_CoA_syn; 1.
DR PANTHER; PTHR42921; ACETOACETYL-COA SYNTHETASE; 1.
DR PANTHER; PTHR42921:SF1; ACETOACETYL-COA SYNTHETASE; 1.
DR Pfam; PF16177; ACAS_N; 1.
DR Pfam; PF00501; AMP-binding; 1.
DR Pfam; PF13193; AMP-binding_C; 1.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 1.
DR PROSITE; PS00455; AMP_BINDING; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Ligase {ECO:0000256|ARBA:ARBA00022598, ECO:0000313|EMBL:KTD16046.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000054761}.
FT DOMAIN 40..95
FT /note="Acetyl-coenzyme A synthetase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF16177"
FT DOMAIN 99..473
FT /note="AMP-dependent synthetase/ligase"
FT /evidence="ECO:0000259|Pfam:PF00501"
FT DOMAIN 544..614
FT /note="AMP-binding enzyme C-terminal"
FT /evidence="ECO:0000259|Pfam:PF13193"
SQ SEQUENCE 652 AA; 73728 MW; 5CF55E0BA8C12D28 CRC64;
MKGGMTVSNI VWKPNHPELT QMWQFMRFIE QKYDLIFENY HQLHEWSIHH PERFWQNLYE
FFSFSFDTSP HEILHPFDEM INARWFTGAR FNFAEKLLSR NDDYPALISI DENNHRQVFS
YRQLRKEVAE CAAGLKSRGI KEGDRVVAVL PNIAATVIAM LATASLGAIW SSCSPDFGAQ
AIIDRLGQIE PKLLFICDGH QYQGKIHSAT EKIKQIAEAI PSLKDIVLIP FVGEKILGKL
SSSIVEWKDF KKTSSSLKFT SLPFNHPLYI LYSSGTTGKP KCIIHGAGGT LLQHMKELGL
HTDIKEGDNL CFYTTCGWMM WNWMVSVLSL GATLTLYEGS PTFPDAGRMF QLIEDEQITV
FGTSAKFISA IEKTGIKPKD KYRLDGLRCI LSTGSPLLPK NYDYVYQQLK PEVQLCSISG
GTDIISCFAL GNPILPVYRG ELQCAGLGMA VEVFDEQGRS VRQTHGELVC TKPFPSMPMG
FWNDPDQSRY KKAYFARFPN VWAHGDFAEI TKHHGLIIHG RSDSVLNPGG VRIGTAEIYR
QIEKIPQVLD SVVVGQNWED DVRVVLFVKL KEGIELSDEL ITTIRQTIRT HASPRHVPAK
ILQVKDIPRT ISGKTVEVAV RKIIHGESIE NVESLANPEA LEYFKNRDEL RT
//
