GenomeNet

Database: UniProt
Entry: A0A0W0WVB7_9GAMM
LinkDB: A0A0W0WVB7_9GAMM
Original site: A0A0W0WVB7_9GAMM 
ID   A0A0W0WVB7_9GAMM        Unreviewed;       501 AA.
AC   A0A0W0WVB7;
DT   16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT   16-MAR-2016, sequence version 1.
DT   24-JAN-2024, entry version 25.
DE   RecName: Full=Histidine ammonia-lyase {ECO:0000256|ARBA:ARBA00012994, ECO:0000256|RuleBase:RU004479};
DE            EC=4.3.1.3 {ECO:0000256|ARBA:ARBA00012994, ECO:0000256|RuleBase:RU004479};
GN   ORFNames=Lnau_1238 {ECO:0000313|EMBL:KTD36254.1};
OS   Legionella nautarum.
OC   Bacteria; Pseudomonadota; Gammaproteobacteria; Legionellales;
OC   Legionellaceae; Legionella.
OX   NCBI_TaxID=45070 {ECO:0000313|EMBL:KTD36254.1, ECO:0000313|Proteomes:UP000054725};
RN   [1] {ECO:0000313|EMBL:KTD36254.1, ECO:0000313|Proteomes:UP000054725}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 49506 {ECO:0000313|EMBL:KTD36254.1,
RC   ECO:0000313|Proteomes:UP000054725};
RA   Burstein D., Amaro F., Zusman T., Lifshitz Z., Cohen O., Gilbert J.A.,
RA   Pupko T., Shuman H.A., Segal G.;
RT   "Genomic analysis of 38 Legionella species identifies large and diverse
RT   effector repertoires.";
RL   Submitted (NOV-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=L-histidine = NH4(+) + trans-urocanate; Xref=Rhea:RHEA:21232,
CC         ChEBI:CHEBI:17771, ChEBI:CHEBI:28938, ChEBI:CHEBI:57595; EC=4.3.1.3;
CC         Evidence={ECO:0000256|ARBA:ARBA00000171,
CC         ECO:0000256|RuleBase:RU004479};
CC   -!- PATHWAY: Amino-acid degradation; L-histidine degradation into L-
CC       glutamate; N-formimidoyl-L-glutamate from L-histidine: step 1/3.
CC       {ECO:0000256|ARBA:ARBA00005113, ECO:0000256|RuleBase:RU004479}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|RuleBase:RU004480}.
CC   -!- SIMILARITY: Belongs to the PAL/histidase family.
CC       {ECO:0000256|RuleBase:RU003954}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KTD36254.1}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; LNYO01000013; KTD36254.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A0W0WVB7; -.
DR   STRING; 45070.Lnau_1238; -.
DR   PATRIC; fig|45070.6.peg.1304; -.
DR   UniPathway; UPA00379; UER00549.
DR   Proteomes; UP000054725; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0004397; F:histidine ammonia-lyase activity; IEA:UniProtKB-EC.
DR   GO; GO:0019556; P:histidine catabolic process to glutamate and formamide; IEA:UniProtKB-UniPathway.
DR   GO; GO:0019557; P:histidine catabolic process to glutamate and formate; IEA:UniProtKB-UniPathway.
DR   CDD; cd00332; PAL-HAL; 1.
DR   Gene3D; 1.20.200.10; Fumarase/aspartase (Central domain); 1.
DR   Gene3D; 1.10.275.10; Fumarase/aspartase (N-terminal domain); 1.
DR   InterPro; IPR001106; Aromatic_Lyase.
DR   InterPro; IPR024083; Fumarase/histidase_N.
DR   InterPro; IPR005921; HutH.
DR   InterPro; IPR008948; L-Aspartase-like.
DR   InterPro; IPR022313; Phe/His_NH3-lyase_AS.
DR   NCBIfam; TIGR01225; hutH; 1.
DR   PANTHER; PTHR10362; HISTIDINE AMMONIA-LYASE; 1.
DR   PANTHER; PTHR10362:SF7; HISTIDINE AMMONIA-LYASE; 1.
DR   Pfam; PF00221; Lyase_aromatic; 1.
DR   SUPFAM; SSF48557; L-aspartase-like; 1.
DR   PROSITE; PS00488; PAL_HISTIDASE; 1.
PE   3: Inferred from homology;
KW   Histidine metabolism {ECO:0000256|ARBA:ARBA00022808,
KW   ECO:0000256|RuleBase:RU004479};
KW   Lyase {ECO:0000256|RuleBase:RU003954, ECO:0000313|EMBL:KTD36254.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000054725}.
SQ   SEQUENCE   501 AA;  53972 MW;  AE98A3BA1615C629 CRC64;
     MELFTLLPGQ LSLHTIKSLT KDKKNCMLDD SAGPMIEASC NIVREVLESK KTVYGINTGF
     GSLACQRIST EHLQQLQRNI VLSHACGAGE LLTDEIVALI LLLKINSLAQ GYSGVRRELI
     DALTILYNKG VYPCIPAKGS VGASGDLVPL AHLSLPLIGE GEVRYQGKIM SAEEGLKLAG
     IKPLELAPKE GLALLNGLQP SAALCMDAFF KAELLFEAAV LAGGLSVDAA CASDVPFDDR
     IHLARGHQAQ RDVAAMYREL LAGSPIRESH RHCNRVQDPY SLRCQPQIMG AVLHQMRFVG
     ETLQVEANSI SDNPLVFVEQ EDILSGGNFH GEMIAMAADN LALAIAEIGA NSERRIALLI
     DKNFSGLPAF LVKEGGLNSG FMIPHVTAAS CASDNKALAH PHSVDSLPTS ANQEDHVSMA
     TNAARRLHTM VDNTATILAI EFLAACQGLE FHKPLTTSPK LAAVYAEVRN FVDAYTMDRY
     FAPDIAIIKQ KILDGDFALE P
//
DBGET integrated database retrieval system