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Database: UniProt
Entry: A0A0W0WYR1_9GAMM
LinkDB: A0A0W0WYR1_9GAMM
Original site: A0A0W0WYR1_9GAMM 
ID   A0A0W0WYR1_9GAMM        Unreviewed;      3158 AA.
AC   A0A0W0WYR1;
DT   16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT   16-MAR-2016, sequence version 1.
DT   24-JAN-2024, entry version 37.
DE   SubName: Full=Type I polyketide synthase WcbR {ECO:0000313|EMBL:KTD37472.1};
GN   Name=rkpA {ECO:0000313|EMBL:KTD37472.1};
GN   ORFNames=Lnau_0662 {ECO:0000313|EMBL:KTD37472.1};
OS   Legionella nautarum.
OC   Bacteria; Pseudomonadota; Gammaproteobacteria; Legionellales;
OC   Legionellaceae; Legionella.
OX   NCBI_TaxID=45070 {ECO:0000313|EMBL:KTD37472.1, ECO:0000313|Proteomes:UP000054725};
RN   [1] {ECO:0000313|EMBL:KTD37472.1, ECO:0000313|Proteomes:UP000054725}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 49506 {ECO:0000313|EMBL:KTD37472.1,
RC   ECO:0000313|Proteomes:UP000054725};
RA   Burstein D., Amaro F., Zusman T., Lifshitz Z., Cohen O., Gilbert J.A.,
RA   Pupko T., Shuman H.A., Segal G.;
RT   "Genomic analysis of 38 Legionella species identifies large and diverse
RT   effector repertoires.";
RL   Submitted (NOV-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=pantetheine 4'-phosphate; Xref=ChEBI:CHEBI:47942;
CC         Evidence={ECO:0000256|ARBA:ARBA00001957};
CC   -!- PATHWAY: Lipid metabolism; fatty acid biosynthesis.
CC       {ECO:0000256|ARBA:ARBA00005194}.
CC   -!- SIMILARITY: Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP
CC       synthases family. {ECO:0000256|ARBA:ARBA00008467}.
CC   -!- SIMILARITY: In the C-terminal section; belongs to the NRP synthetase
CC       family. {ECO:0000256|ARBA:ARBA00029443}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KTD37472.1}.
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DR   EMBL; LNYO01000011; KTD37472.1; -; Genomic_DNA.
DR   RefSeq; WP_058503732.1; NZ_LNYO01000011.1.
DR   STRING; 45070.Lnau_0662; -.
DR   PATRIC; fig|45070.6.peg.706; -.
DR   OrthoDB; 5657178at2; -.
DR   UniPathway; UPA00094; -.
DR   Proteomes; UP000054725; Unassembled WGS sequence.
DR   GO; GO:0004315; F:3-oxoacyl-[acyl-carrier-protein] synthase activity; IEA:InterPro.
DR   GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR   GO; GO:0006633; P:fatty acid biosynthetic process; IEA:UniProtKB-UniPathway.
DR   GO; GO:0046483; P:heterocycle metabolic process; IEA:UniProt.
DR   GO; GO:1901360; P:organic cyclic compound metabolic process; IEA:UniProt.
DR   GO; GO:1901566; P:organonitrogen compound biosynthetic process; IEA:UniProt.
DR   CDD; cd05930; A_NRPS; 1.
DR   CDD; cd00833; PKS; 1.
DR   Gene3D; 3.30.300.30; -; 1.
DR   Gene3D; 3.30.70.3290; -; 1.
DR   Gene3D; 3.40.47.10; -; 1.
DR   Gene3D; 1.10.1200.10; ACP-like; 2.
DR   Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 1.
DR   Gene3D; 3.40.366.10; Malonyl-Coenzyme A Acyl Carrier Protein, domain 2; 1.
DR   Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 2.
DR   Gene3D; 3.30.559.30; Nonribosomal peptide synthetase, condensation domain; 1.
DR   Gene3D; 3.10.129.110; Polyketide synthase dehydratase; 1.
DR   InterPro; IPR010071; AA_adenyl_domain.
DR   InterPro; IPR001227; Ac_transferase_dom_sf.
DR   InterPro; IPR036736; ACP-like_sf.
DR   InterPro; IPR014043; Acyl_transferase.
DR   InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR   InterPro; IPR045851; AMP-bd_C_sf.
DR   InterPro; IPR020845; AMP-binding_CS.
DR   InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR   InterPro; IPR042099; ANL_N_sf.
DR   InterPro; IPR023213; CAT-like_dom_sf.
DR   InterPro; IPR001242; Condensatn.
DR   InterPro; IPR013120; Far_NAD-bd.
DR   InterPro; IPR018201; Ketoacyl_synth_AS.
DR   InterPro; IPR014031; Ketoacyl_synth_C.
DR   InterPro; IPR014030; Ketoacyl_synth_N.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR   InterPro; IPR042104; PKS_dehydratase_sf.
DR   InterPro; IPR020807; PKS_DH.
DR   InterPro; IPR013968; PKS_KR.
DR   InterPro; IPR020806; PKS_PP-bd.
DR   InterPro; IPR009081; PP-bd_ACP.
DR   InterPro; IPR006162; Ppantetheine_attach_site.
DR   InterPro; IPR016039; Thiolase-like.
DR   NCBIfam; TIGR01733; AA-adenyl-dom; 1.
DR   PANTHER; PTHR43775; FATTY ACID SYNTHASE; 1.
DR   PANTHER; PTHR43775:SF37; FATTY ACID SYNTHASE; 1.
DR   Pfam; PF00698; Acyl_transf_1; 1.
DR   Pfam; PF00501; AMP-binding; 1.
DR   Pfam; PF00668; Condensation; 1.
DR   Pfam; PF00109; ketoacyl-synt; 1.
DR   Pfam; PF02801; Ketoacyl-synt_C; 1.
DR   Pfam; PF08659; KR; 1.
DR   Pfam; PF07993; NAD_binding_4; 1.
DR   Pfam; PF21089; PKS_DH_N; 1.
DR   Pfam; PF00550; PP-binding; 2.
DR   Pfam; PF14765; PS-DH; 1.
DR   SMART; SM00827; PKS_AT; 1.
DR   SMART; SM00822; PKS_KR; 1.
DR   SMART; SM00825; PKS_KS; 1.
DR   SMART; SM00823; PKS_PP; 2.
DR   SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 1.
DR   SUPFAM; SSF47336; ACP-like; 2.
DR   SUPFAM; SSF52777; CoA-dependent acyltransferases; 2.
DR   SUPFAM; SSF52151; FabD/lysophospholipase-like; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 2.
DR   SUPFAM; SSF53901; Thiolase-like; 1.
DR   PROSITE; PS00455; AMP_BINDING; 1.
DR   PROSITE; PS50075; CARRIER; 2.
DR   PROSITE; PS00606; KS3_1; 1.
DR   PROSITE; PS52004; KS3_2; 1.
DR   PROSITE; PS00012; PHOSPHOPANTETHEINE; 1.
PE   3: Inferred from homology;
KW   Fatty acid biosynthesis {ECO:0000256|ARBA:ARBA00023160};
KW   Fatty acid metabolism {ECO:0000256|ARBA:ARBA00023160};
KW   Lipid biosynthesis {ECO:0000256|ARBA:ARBA00023160};
KW   Lipid metabolism {ECO:0000256|ARBA:ARBA00023160};
KW   Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW   Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW   Reference proteome {ECO:0000313|Proteomes:UP000054725};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT   DOMAIN          4..415
FT                   /note="Ketosynthase family 3 (KS3)"
FT                   /evidence="ECO:0000259|PROSITE:PS52004"
FT   DOMAIN          1615..1696
FT                   /note="Carrier"
FT                   /evidence="ECO:0000259|PROSITE:PS50075"
FT   DOMAIN          2710..2785
FT                   /note="Carrier"
FT                   /evidence="ECO:0000259|PROSITE:PS50075"
SQ   SEQUENCE   3158 AA;  355502 MW;  C03AB31E3D015C60 CRC64;
     MKQHSPISII GMACEFAGQA DSLANFYKVI LEGVDATSDI SEGRWNVDLD SLPQSIRHGG
     FLKRNPWSFD AQFFAISPKE AAHMDPQHRI LLEQTYHALE DTNLDLDTIK GSNCGVFIGL
     GTQDYSRIMH NSGQFSGLHS KGSLGSMAAG RIAYHFDLIG PNFVVDTACS SSLVALDQAV
     KALQDHRCDL AIVGGVTLIL TTDYNTDLAS ANLLAKDGRC KPFSKGADGF ARGEGVGVII
     LQRRQEALRD KRRIYANILG SAINSDGKTN GITAPSKESQ KRVIQDALKD AQISAQEVNF
     IETHGTGTDL GDKIEFAALI EIYQGREEPL YIGSVKGNIA HCEAAAGIAG VIKTSLCIYH
     DLIPPHTAAN FLNPDLRVAS LKAQFPAQVL PKRNIVGTVS SFGMSGANAE VVLADEPTKN
     AAASADCPQV YPYLLLSAKS AESLHKLGSE YRLLLEHCEE EAFNKCLSQA NLRNNCSGYR
     KLVYGQDKTA LLKQLDKIDL TALKKRMVKG KTKFAFMFTG QGAVFKEMTR VLYDRIPLYR
     NILNDYAAKM DDVIHLPHKI ISYIFNDEFS LSLDDPQTAQ LSLFLIEFSL ARLLNLLGIT
     PDFVVGHSLG EYAAACSAGI LSFEQAVQMV NLRSQAIKEE PGLQDGLMLQ IYATNELVQK
     LLAELRLKNP LLALWISVNN APEIQVVSGN KESVLQLTDL LKQKGIPYLK LNTSHAFHTP
     CLELAATNFK DRALASAMSF TLKNSITSFI STAEPHRDDN QNQAFASIDY WAAQIVKPVR
     FVDAIESCYE LGVRSFIEIG PDSILTNLAR QCLKNKESSA ELEFIAMNSK NKNNLDSLFS
     VLNYFYSTHR LDGSKLGLLD DKQRVFSSFF LPVYPFARVE LLPDYLKNSR VPAVIEKNNS
     KKIRLEPTHL EFQINLDLSQ IEHAYIAQHV IHEMCILPGS YYIATSIQLL ETFKESYLAN
     QPQTIIELDN LLIMHPVIIS QSGQESLKVT IHQQKPNQYK FSYFCLAEID QLVCEMTLLL
     KSYEEPNCVE INQGTKIQDT SEFYSNYAVC GVNYGPLFKK QKSYYNLDSQ NIISELEAAE
     GYFTSHAAFI DNCFQTMALG LNQLGSAFAP TAVNQFKFYK EEKWGVGLGC HAQIIEQKEG
     HLEANLKVYN AQNKVVMEIN GIVCKSIQLD ALSANVIHKV ALEKIAVSAP DNSLKDFAFL
     ANFKTEWVKP ESILAWSDLQ AKTTIDVRHL IIGFDGLAWD KNELFSLFQC LFNFLRLQAE
     KISGNLKVIS FLSLNDKAKD YKKLLAPLLK AMTLAFPTEF PNLSFRHFSY TKLTKDNIAF
     LFAEDKELPT DHEFLIPFWE VYGNELYRYK TIPQKPNQAE PLPKEGYYLI TGGLGGIGKT
     LVRHMVSNLG CRNLILTYRK LEPEAEQFIT ELNDQYDANI RCHHVDLRSE SQLVKLFATL
     PRPLYGIFHL AGIIQDQSLA KTSPHSIENV LAAKLFSAWT LHELSQEITE LKAFVLFSSL
     ATLISSPGQF NYALANLGLQ ELAAHRKNSH LPVSLIDWGP WANIGMMANS DSLSASSIVL
     SKFVPLSPTI CHEALFSCLN QTNDSHFAVF KMNKREPIVR TSVESETKIS LNPHSSKKEA
     AQFIKALLLR LIAQETNHAS ASIDEHLILS ELGLDSINTI RIRAELQTEL NLAIPLSILL
     EETTLERLVD QVLVLWLANQ NNQNQHSESN EEASVNRGDA NFFSLSYNQF SIWYEQHAIE
     NNQAYHCSIG WKIRGGDLNL KQVYANWEVL ISRHEMLRAL FSSREGNLGY ELLSVSQALE
     QQMVVVETIE ADRDPQQYLQ NYLLRKIDFN RELPTKVLIL SHQNDVYLML SSHHIVMDAA
     AMFYLGKKLL TSLCEADYVL DKDFSSQPYH EFTKQQFLQS AEFDLKTLSF LRKEVLNEEG
     ELRVFELPKK SNTGILNLAK GATKTILFSE MEMQIIQSLP ASIRVHLCLS AWALLLAKYS
     GEENLLIGVA FNGRTQKKWT EVVGHFVNVL PLCIKVNQHQ ASNQFINEIK SRLIELLEFQ
     DFPLVKLMKD PEVKQALQGR PLLQTYFNYF DASDLDISVN NQLVTIDALV YPQQEAQFEM
     SLWVTRTSRG FDFEVKYQRE LFSETMLEKL VGYYKTVLIA LSQALLQSNT QLKLAEIQFL
     SETELAKRLP PESTNRPSQL VYNYFAEQAA SLPQSVAIEM REQNISYQSL QGWVDELALA
     LTEFPQSKDE TVAIIAPERA NIEFIVTVLA LWKQGFAFVP LNSHHPFERI KYVLDTVGCR
     KLILVDVLSP NLENYICTNN KLLLEVRIEF PQLQIQVLNE SIPEENDRFE NRSQANPSDL
     AYILFTSGST GLPKGVLIEQ EGLIDRLLWM KNYFNFSAAD KFLQSTLLTF DVSLPEYCLP
     LICGATIVLF HPEESQNAHA ALCTYHQVTM MSTVPSLFSI LLSDLAGCPT LKHLIMIGEV
     LPRAIVNKWL ASNQTCTLYN LYGPTEVTVY ASAHACREPI NSALVPIGEA ADNVIPLVLD
     QYGNPVLDEV IGELYLAGSG VARGYIGGQL KSDPFINNPW QSLHYTRMYK TGDFVRWLEG
     GRLEYIGRKD NRIKLNGLLV ELGEIEERVL KAFPDLENAC AIITEFKIKE TLIKHIVLCI
     MPECTDSSII MEHLKQHLPQ YMLPWKIISY AEFPRNSSAK VDRKLLTNLV KELYEEESVQ
     AKLRPKSSHQ PVTFMEKEIC KIWETLLQKS NLGIDENFFE LGGDSLLLTQ MILLVEKQLG
     IKTNFAKFLA NPSINSLLHG LSMESPIWEN EFKLLKAISP YQEVKKTKAV LLTGGTGHLG
     IHLLRSLLNQ TDKQIYLIIR AESKTKAIER LTERYFSVFG DSLALNRLCI YSGDLALLNF
     GLEEADFQKL CQEISLIIHA AAEVNHVVDY VRLKKSNVLV SKNMLDLARS AHCTHFFHIS
     TQFSELSILP ESYMNETSIN EFSSGYEQSK FIAESLMSAA KNLKYPVTTL RLPLIIDDSD
     PLLLRQNHFV AFVMKCLRLG AYPDIGLSFA LLATADLADF VAELSNKSYL EPEVYNCHTR
     RISLQELFDF FITETEYKVN KLEPSLWKAR VLESTYETDP FYKLLPLYTS SLLISENVNE
     QLIEHKGFLK AIETTKLAVT DNAHIKKIGS MLANYSRL
//
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