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Database: UniProt
Entry: A0A0W0ZAL6_LEGSP
LinkDB: A0A0W0ZAL6_LEGSP
Original site: A0A0W0ZAL6_LEGSP 
ID   A0A0W0ZAL6_LEGSP        Unreviewed;       455 AA.
AC   A0A0W0ZAL6;
DT   16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT   16-MAR-2016, sequence version 1.
DT   25-OCT-2017, entry version 13.
DE   RecName: Full=Exodeoxyribonuclease 7 large subunit {ECO:0000256|HAMAP-Rule:MF_00378};
DE            EC=3.1.11.6 {ECO:0000256|HAMAP-Rule:MF_00378};
DE   AltName: Full=Exodeoxyribonuclease VII large subunit {ECO:0000256|HAMAP-Rule:MF_00378};
DE            Short=Exonuclease VII large subunit {ECO:0000256|HAMAP-Rule:MF_00378};
GN   Name=xseA {ECO:0000256|HAMAP-Rule:MF_00378,
GN   ECO:0000313|EMBL:KTD66171.1};
GN   ORFNames=Lspi_0234 {ECO:0000313|EMBL:KTD66171.1};
OS   Legionella spiritensis.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Legionellales;
OC   Legionellaceae; Legionella.
OX   NCBI_TaxID=452 {ECO:0000313|EMBL:KTD66171.1, ECO:0000313|Proteomes:UP000054877};
RN   [1] {ECO:0000313|EMBL:KTD66171.1, ECO:0000313|Proteomes:UP000054877}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Mt.St.Helens-9 {ECO:0000313|EMBL:KTD66171.1,
RC   ECO:0000313|Proteomes:UP000054877};
RA   Burstein D., Amaro F., Zusman T., Lifshitz Z., Cohen O., Gilbert J.A.,
RA   Pupko T., Shuman H.A., Segal G.;
RT   "Genomic analysis of 38 Legionella species identifies large and
RT   diverse effector repertoires.";
RL   Submitted (NOV-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Bidirectionally degrades single-stranded DNA into large
CC       acid-insoluble oligonucleotides, which are then degraded further
CC       into small acid-soluble oligonucleotides. {ECO:0000256|HAMAP-
CC       Rule:MF_00378, ECO:0000256|SAAS:SAAS00723532}.
CC   -!- CATALYTIC ACTIVITY: Exonucleolytic cleavage in either 5'- to
CC       3'- or 3'- to 5'-direction to yield nucleoside 5'-phosphates.
CC       {ECO:0000256|HAMAP-Rule:MF_00378, ECO:0000256|RuleBase:RU004355,
CC       ECO:0000256|SAAS:SAAS00723505}.
CC   -!- SUBUNIT: Heterooligomer composed of large and small subunits.
CC       {ECO:0000256|HAMAP-Rule:MF_00378}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00378,
CC       ECO:0000256|RuleBase:RU004355, ECO:0000256|SAAS:SAAS00723552}.
CC   -!- SIMILARITY: Belongs to the XseA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00378, ECO:0000256|RuleBase:RU004355,
CC       ECO:0000256|SAAS:SAAS00723548}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:KTD66171.1}.
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DR   EMBL; LNYX01000002; KTD66171.1; -; Genomic_DNA.
DR   EnsemblBacteria; KTD66171; KTD66171; Lspi_0234.
DR   PATRIC; fig|452.5.peg.257; -.
DR   Proteomes; UP000054877; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0009318; C:exodeoxyribonuclease VII complex; IEA:InterPro.
DR   GO; GO:0008855; F:exodeoxyribonuclease VII activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0006308; P:DNA catabolic process; IEA:UniProtKB-UniRule.
DR   CDD; cd04489; ExoVII_LU_OBF; 1.
DR   HAMAP; MF_00378; Exonuc_7_L; 1.
DR   InterPro; IPR003753; Exonuc_VII_L.
DR   InterPro; IPR020579; Exonuc_VII_lsu_C.
DR   InterPro; IPR025824; OB-fold_nuc-bd_dom.
DR   PANTHER; PTHR30008; PTHR30008; 1.
DR   Pfam; PF02601; Exonuc_VII_L; 1.
DR   Pfam; PF13742; tRNA_anti_2; 1.
DR   TIGRFAMs; TIGR00237; xseA; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000054877};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00378,
KW   ECO:0000256|SAAS:SAAS00723549};
KW   Exonuclease {ECO:0000256|HAMAP-Rule:MF_00378,
KW   ECO:0000256|RuleBase:RU004355, ECO:0000256|SAAS:SAAS00723511,
KW   ECO:0000313|EMBL:KTD66171.1};
KW   Hydrolase {ECO:0000256|HAMAP-Rule:MF_00378,
KW   ECO:0000256|RuleBase:RU004355, ECO:0000256|SAAS:SAAS00723558,
KW   ECO:0000313|EMBL:KTD66171.1};
KW   Nuclease {ECO:0000256|HAMAP-Rule:MF_00378,
KW   ECO:0000256|RuleBase:RU004355, ECO:0000256|SAAS:SAAS00723518};
KW   Reference proteome {ECO:0000313|Proteomes:UP000054877}.
FT   DOMAIN        4     96       tRNA_anti_2. {ECO:0000259|Pfam:PF13742}.
FT   DOMAIN      120    431       Exonuc_VII_L. {ECO:0000259|Pfam:PF02601}.
FT   COILED      364    388       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   455 AA;  51444 MW;  4CC8CBFE6EEAEBF0 CRC64;
     MSTLTVSQLN RQIRTWLEKD IGEVSVVGEL SGISKPASGH YYFTLKDQTA QIRCVFFRNY
     HQPDSKLFKD GQQAIVRGKP SLYEARGDYQ LIVQELTAYG LGELYRQFEL LKNRLEQQGL
     FAAHRKKVLP EFPGNIAVIT SSSGAALHDI LTTLSRRYPL AAIYIYASEV QGKGAAPQLI
     QALKQANADH HCDVILLARG GGSIEDLWAF NDEQLARAIS ESRLPVVTGI GHETDFTIAD
     FVADYRAATP TAAAEAVTPD QYELLKLIQT FITRLIRAAG HMMQQRQMKL SHQIIKIASP
     EQLIYKYWQT LDHLQRQLTQ TLQQRIHRQQ HRLHLACTHL QARHPVTLLH RSLSLAQQYE
     QRLVHAVNER LEKLRQRLTN QLATLHAVSP LATLDRGYAI ATHHSKIVFN SRQVEAGDRI
     ELKLSRGELT CEVLDSKAPD RTTRPGKLNH ARGTQ
//
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