ID   A0A0W7VU27_9HYPO        Unreviewed;       338 AA.
AC   A0A0W7VU27;
DT   16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT   16-MAR-2016, sequence version 1.
DT   13-SEP-2023, entry version 30.
DE   RecName: Full=Methylenetetrahydrofolate dehydrogenase (NAD+) {ECO:0008006|Google:ProtNLM};
GN   ORFNames=TGAMA5MH_05284 {ECO:0000313|EMBL:PNP42543.1};
OS   Trichoderma gamsii.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Hypocreomycetidae; Hypocreales; Hypocreaceae; Trichoderma.
OX   NCBI_TaxID=398673 {ECO:0000313|EMBL:PNP42543.1, ECO:0000313|Proteomes:UP000236546};
RN   [1] {ECO:0000313|EMBL:PNP42543.1, ECO:0000313|Proteomes:UP000236546}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=A5MH {ECO:0000313|EMBL:PNP42543.1,
RC   ECO:0000313|Proteomes:UP000236546};
RA   Gardiner D., Kazan K., Vos C., Harvey P.;
RT   "Genomes of Trichoderma spp. with biocontrol activity.";
RL   Submitted (FEB-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:PNP42543.1}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; MTYH01000050; PNP42543.1; -; Genomic_DNA.
DR   RefSeq; XP_018662981.1; XM_018803930.1.
DR   AlphaFoldDB; A0A0W7VU27; -.
DR   Proteomes; UP000236546; Unassembled WGS sequence.
DR   GO; GO:0004488; F:methylenetetrahydrofolate dehydrogenase (NADP+) activity; IEA:InterPro.
DR   GO; GO:0006730; P:one-carbon metabolic process; IEA:UniProtKB-KW.
DR   CDD; cd01079; NAD_bind_m-THF_DH; 1.
DR   Gene3D; 3.40.50.10860; Leucine Dehydrogenase, chain A, domain 1; 1.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   InterPro; IPR046346; Aminoacid_DH-like_N_sf.
DR   InterPro; IPR035812; m-THF_DH_NAD-bd.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR000672; THF_DH/CycHdrlase.
DR   InterPro; IPR020630; THF_DH/CycHdrlase_cat_dom.
DR   InterPro; IPR020631; THF_DH/CycHdrlase_NAD-bd_dom.
DR   PANTHER; PTHR48099; C-1-TETRAHYDROFOLATE SYNTHASE, CYTOPLASMIC-RELATED; 1.
DR   PANTHER; PTHR48099:SF3; METHYLENETETRAHYDROFOLATE DEHYDROGENASE [NAD(+)]; 1.
DR   Pfam; PF00763; THF_DHG_CYH; 1.
DR   Pfam; PF02882; THF_DHG_CYH_C; 1.
DR   PRINTS; PR00085; THFDHDRGNASE.
DR   SUPFAM; SSF53223; Aminoacid dehydrogenase-like, N-terminal domain; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE   4: Predicted;
KW   One-carbon metabolism {ECO:0000256|ARBA:ARBA00022563}.
FT   DOMAIN          13..126
FT                   /note="Tetrahydrofolate dehydrogenase/cyclohydrolase
FT                   catalytic"
FT                   /evidence="ECO:0000259|Pfam:PF00763"
FT   DOMAIN          149..216
FT                   /note="Tetrahydrofolate dehydrogenase/cyclohydrolase
FT                   NAD(P)-binding"
FT                   /evidence="ECO:0000259|Pfam:PF02882"
SQ   SEQUENCE   338 AA;  37545 MW;  8A560D9285C21080 CRC64;
     MASEVAPKTC KVITAETIAK KLLLEVKDTL SKVQEAGTSA PTLVAFLATD DPAAVQYAEW
     SKKTCEENGF NFELRRVDKD VIEEDIMKAN EEDAVDGILV YYPIFPKNPS QDKYVQETVD
     LTKDVEGMRH TYLHNMYHNI RFLDPPENKK KSILPCTPLA VVKILEHLQI YNPILAYGNR
     LFGKTITVIN RSEVNGRPLA ALLANDGATV YSVDITGVQL FTRGQGIKKI RHQVEDKEGW
     GLEQCLPLSD VIIGGVPVES FKIPTELIRE GAVCINFASF KNFDGAAVKE KASIYVPSVG
     KVTIAILLRN LVRLVANRPP KEDKSTIQAR TEAFADEI
//