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Database: UniProt
Entry: A0A0W7WZ09_9ACTN
LinkDB: A0A0W7WZ09_9ACTN
Original site: A0A0W7WZ09_9ACTN 
ID   A0A0W7WZ09_9ACTN        Unreviewed;       719 AA.
AC   A0A0W7WZ09;
DT   16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT   16-MAR-2016, sequence version 1.
DT   25-OCT-2017, entry version 16.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|HAMAP-Rule:MF_00377, ECO:0000256|RuleBase:RU000577};
GN   Name=dnaA {ECO:0000256|HAMAP-Rule:MF_00377};
GN   ORFNames=AT728_13885 {ECO:0000313|EMBL:KUF15807.1};
OS   Streptomyces silvensis.
OC   Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
OC   Streptomyces.
OX   NCBI_TaxID=1765722 {ECO:0000313|EMBL:KUF15807.1, ECO:0000313|Proteomes:UP000054804};
RN   [1] {ECO:0000313|EMBL:KUF15807.1, ECO:0000313|Proteomes:UP000054804}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 53525 {ECO:0000313|EMBL:KUF15807.1,
RC   ECO:0000313|Proteomes:UP000054804};
RA   Johnston C.W., Li Y., Magarvey N.A.;
RT   "Draft genome sequence of Streptomyces silvensis ATCC 53525, a
RT   producer of novel hormone antagonists.";
RL   Submitted (DEC-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00735475}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|SAAS:SAAS00911680}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00377, ECO:0000256|RuleBase:RU004227,
CC       ECO:0000256|SAAS:SAAS00555179}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:KUF15807.1}.
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DR   EMBL; LOCL01000042; KUF15807.1; -; Genomic_DNA.
DR   RefSeq; WP_058850039.1; NZ_LOCL01000042.1.
DR   EnsemblBacteria; KUF15807; KUF15807; AT728_13885.
DR   Proteomes; UP000054804; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-UniRule.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-UniRule.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF2; PTHR30050:SF2; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00747950};
KW   Complete proteome {ECO:0000313|Proteomes:UP000054804};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|SAAS:SAAS00911664};
KW   DNA replication {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU004227, ECO:0000256|SAAS:SAAS00747996};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00911684};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00747895};
KW   Reference proteome {ECO:0000313|Proteomes:UP000054804}.
FT   DOMAIN      412    540       AAA. {ECO:0000259|SMART:SM00382}.
FT   DOMAIN      626    695       Bac_DnaA_C. {ECO:0000259|SMART:SM00760}.
FT   NP_BIND     420    427       ATP. {ECO:0000256|HAMAP-Rule:MF_00377}.
SQ   SEQUENCE   719 AA;  79568 MW;  F97AE73D73D7A455 CRC64;
     MADVPADLAA VWPRVLEQLL GEGRGQGVEA KDEHWIKRCQ PLALVADTAL LAVPNEFAKG
     VLEGRLAPVV SETLSRECGR PIRIAITVDD SMGEPATPPA PPVQQQPRYD EQPSRPSQYD
     EQPSRYDEQS SRSSQYDEQP PRYDGQPSRS SHYDEHPPRY EEQELPPAGQ GHDSRDAHDS
     RDPRDPRDPR DARDPHGSHD AYDGYGRRPA DDQLPTARPA YPGYQRPGAW PQQPQDDYGW
     QQPRLGYPDR DPYANPPQQP QHDYRSQPPE RGPYDQDRQH QDRQSQDRHE RRERHDRNES
     GGAGTGGHSS HTGPSGHSSH TGHSSHTGHS GPGGQGGRGG PGGPPMGRGG TPLPASSGAP
     GPLAAQPAPA TGPGEPTARL NPKYLFDTFV IGASNRFAHA AAVAVAEAPA KAYNPLFIYG
     ESGLGKTHLL HAIGHYARSL YPGTRVRYVS SEEFTNEFIN SIRDGKGDSF RKRYREMDIL
     LVDDIQFLAD KESTQEEFFH TFNTLHNANK QIVLSSDRPP KQLVTLEDRL RNRFEWGLIT
     DVQPPELETR IAILRKKAVQ EQLNAPPEVL EFIASRISRN IRELEGALIR VTAFASLNRQ
     PVDLGLTEIV LKDLIPGGED AAPEITATAI MAATADYFGL TVDDLCGSSR SRVLVTARQI
     AMYLCRELTD LSLPKIGAQF GGRDHTTVMH ADRKIRALMA ERRSIYNQVT ELTNRIKNG
//
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