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Database: UniProt
Entry: A0A0W7X0Y6_9ACTN
LinkDB: A0A0W7X0Y6_9ACTN
Original site: A0A0W7X0Y6_9ACTN 
ID   A0A0W7X0Y6_9ACTN        Unreviewed;       580 AA.
AC   A0A0W7X0Y6;
DT   16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT   16-MAR-2016, sequence version 1.
DT   24-JAN-2024, entry version 17.
DE   SubName: Full=Pyruvate dehydrogenase {ECO:0000313|EMBL:KUF16476.1};
GN   ORFNames=AT728_11825 {ECO:0000313|EMBL:KUF16476.1};
OS   Streptomyces silvensis.
OC   Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC   Streptomycetaceae; Streptomyces.
OX   NCBI_TaxID=1765722 {ECO:0000313|EMBL:KUF16476.1, ECO:0000313|Proteomes:UP000054804};
RN   [1] {ECO:0000313|EMBL:KUF16476.1, ECO:0000313|Proteomes:UP000054804}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 53525 {ECO:0000313|EMBL:KUF16476.1,
RC   ECO:0000313|Proteomes:UP000054804};
RA   Johnston C.W., Li Y., Magarvey N.A.;
RT   "Draft genome sequence of Streptomyces silvensis ATCC 53525, a producer of
RT   novel hormone antagonists.";
RL   Submitted (DEC-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the TPP enzyme family.
CC       {ECO:0000256|ARBA:ARBA00007812, ECO:0000256|RuleBase:RU362132}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KUF16476.1}.
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DR   EMBL; LOCL01000038; KUF16476.1; -; Genomic_DNA.
DR   RefSeq; WP_058849293.1; NZ_LOCL01000038.1.
DR   AlphaFoldDB; A0A0W7X0Y6; -.
DR   STRING; 1765722.AT728_11825; -.
DR   OrthoDB; 4959782at2; -.
DR   Proteomes; UP000054804; Unassembled WGS sequence.
DR   GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR   GO; GO:0000287; F:magnesium ion binding; IEA:InterPro.
DR   GO; GO:0030976; F:thiamine pyrophosphate binding; IEA:InterPro.
DR   CDD; cd02014; TPP_POX; 1.
DR   CDD; cd07039; TPP_PYR_POX; 1.
DR   Gene3D; 3.40.50.970; -; 2.
DR   Gene3D; 3.40.50.1220; TPP-binding domain; 1.
DR   InterPro; IPR029035; DHS-like_NAD/FAD-binding_dom.
DR   InterPro; IPR047211; POXB-like.
DR   InterPro; IPR029061; THDP-binding.
DR   InterPro; IPR012000; Thiamin_PyroP_enz_cen_dom.
DR   InterPro; IPR012001; Thiamin_PyroP_enz_TPP-bd_dom.
DR   InterPro; IPR011766; TPP_enzyme_TPP-bd.
DR   InterPro; IPR047212; TPP_POXB-like.
DR   InterPro; IPR047210; TPP_PYR_POXB-like.
DR   PANTHER; PTHR42981; PYRUVATE DEHYDROGENASE [UBIQUINONE]; 1.
DR   PANTHER; PTHR42981:SF2; PYRUVATE DEHYDROGENASE [UBIQUINONE]; 1.
DR   Pfam; PF02775; TPP_enzyme_C; 1.
DR   Pfam; PF00205; TPP_enzyme_M; 1.
DR   Pfam; PF02776; TPP_enzyme_N; 1.
DR   SUPFAM; SSF52467; DHS-like NAD/FAD-binding domain; 1.
DR   SUPFAM; SSF52518; Thiamin diphosphate-binding fold (THDP-binding); 2.
PE   3: Inferred from homology;
KW   Pyruvate {ECO:0000313|EMBL:KUF16476.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000054804};
KW   Thiamine pyrophosphate {ECO:0000256|RuleBase:RU362132}.
FT   DOMAIN          5..116
FT                   /note="Thiamine pyrophosphate enzyme N-terminal TPP-
FT                   binding"
FT                   /evidence="ECO:0000259|Pfam:PF02776"
FT   DOMAIN          192..320
FT                   /note="Thiamine pyrophosphate enzyme central"
FT                   /evidence="ECO:0000259|Pfam:PF00205"
FT   DOMAIN          383..529
FT                   /note="Thiamine pyrophosphate enzyme TPP-binding"
FT                   /evidence="ECO:0000259|Pfam:PF02775"
SQ   SEQUENCE   580 AA;  62380 MW;  5A7646FCD62CEA5B CRC64;
     MAKQKVAEQF VDILVRAGVE RLYGVVGDSL NPVVDAIRRT KGIEWIQVRH EETAAFAAGA
     EAQITGSLAA CAGSCGPGNL HLINGLYDAH RSMAPVLALA SQIPSSEIGL GFFQETHPDR
     LFRECSHYCE LISSPQQMPR LLQTAIQHAV GQSGVSVVSL PGDVASEAAP DKAAETALVT
     SRPTVRPGDA EIDKLVAMID EADKVTLFCG SGTAGAHAEV MEFAEKIKSP VGHALRGKEW
     IQYDNPYDVG MSGLLGYGAA YEATHECDLL IMLGTDFPYN AFLPDDVKIA QVDVRPENLG
     RRSRLDLAVW GDVRETLRCL TPRVSPKSHR KFLDKMLKKH ADALEGVVKA YTRKVEKHIP
     IHPEYVASVL DDLAADDAVF TVDTGMCNVW AARYLSPNGK RRIIGSFSHG SMANALPQAI
     GAQFTDRERQ VVSMSGDGGF TMLMGDFLTL VQYDLPVKVI LFNNSSLGMV ELEMLVAGLP
     SYGTGNHNPD FAAVARAAGA YGVRVEKPKQ LAGALKDAFA HKGPALVDVV TDPNALSIPP
     RISSDMVTGF ALSASKIVLD GGVGRMLQMA RSNLRNVPRP
//
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