ID A0A0W8C0X3_PHYNI Unreviewed; 671 AA.
AC A0A0W8C0X3;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=sphingosine kinase {ECO:0000256|ARBA:ARBA00044037};
DE EC=2.7.1.91 {ECO:0000256|ARBA:ARBA00044037};
GN ORFNames=AM587_10005387 {ECO:0000313|EMBL:KUF77633.1};
OS Phytophthora nicotianae (Buckeye rot agent).
OC Eukaryota; Sar; Stramenopiles; Oomycota; Peronosporales; Peronosporaceae;
OC Phytophthora.
OX NCBI_TaxID=4790 {ECO:0000313|EMBL:KUF77633.1, ECO:0000313|Proteomes:UP000052943};
RN [1] {ECO:0000313|EMBL:KUF77633.1, ECO:0000313|Proteomes:UP000052943}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=race 0 {ECO:0000313|Proteomes:UP000052943};
RA Liu H., Ma X., Yu H., Fang D., Li Y., Wang X., Wang W., Dong Y., Xiao B.;
RT "Genomes and virulence difference between two physiological races of
RT Phytophthora nicotianae.";
RL Submitted (NOV-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a sphingoid base + ATP = a sphingoid 1-phosphate + ADP + H(+);
CC Xref=Rhea:RHEA:51496, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:76941, ChEBI:CHEBI:84410, ChEBI:CHEBI:456216;
CC EC=2.7.1.91; Evidence={ECO:0000256|ARBA:ARBA00043822};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KUF77633.1}.
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DR EMBL; LNFO01005530; KUF77633.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0W8C0X3; -.
DR STRING; 4790.A0A0W8C0X3; -.
DR EnsemblProtists; KUF77633; KUF77633; AM587_10005387.
DR OMA; DAESIFC; -.
DR Proteomes; UP000052943; Unassembled WGS sequence.
DR GO; GO:0016301; F:kinase activity; IEA:InterPro.
DR Gene3D; 2.60.200.40; -; 1.
DR InterPro; IPR017438; ATP-NAD_kinase_N.
DR InterPro; IPR001206; Diacylglycerol_kinase_cat_dom.
DR InterPro; IPR016064; NAD/diacylglycerol_kinase_sf.
DR PANTHER; PTHR12358:SF31; LD11247P-RELATED; 1.
DR PANTHER; PTHR12358; SPHINGOSINE KINASE; 1.
DR Pfam; PF00781; DAGK_cat; 1.
DR SMART; SM00046; DAGKc; 1.
DR SUPFAM; SSF111331; NAD kinase/diacylglycerol kinase-like; 1.
DR PROSITE; PS50146; DAGK; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000052943}.
FT DOMAIN 297..437
FT /note="DAGKc"
FT /evidence="ECO:0000259|PROSITE:PS50146"
FT REGION 1..134
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 8..29
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 59..77
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 115..134
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 671 AA; 75343 MW; 1A18E110092F69D1 CRC64;
MAVLPTSARD DEPEHIGPVK TIEDENQLFH EPQDDSDDDV DVKTKRLSNA TAASSDGEAL
TGEDRDRIRE VRERILQDAA NRPVSPAKNH FRRASTVAVP TQGLVPRKDA PAQDNDSSSE
AGETPTSLRL TRSKSWAGCP QRDAAIEAIE NRQVRFRFST AASAREIVRE MHSHRLREFP
EQCVMTAQME MQIGSVWRKM TVQVDRDGIN CQRVSLFRKK TKEFQIFKDD LLAASLTPGS
KTSVDVHFML PGRGKEHRRL MRRYRTITLR FSDEATANKL VASLQALVKW LARVPENVTR
RIKVVVNPHS GRRRGRKVWE HWRPLLELAN IQCDVEETQY SGHARDIGAA FDLDMKYEAI
VFVGGDGTVN EFMNGVFSRE ESVWRTLVAT TPVSLICAGT DNAFGKGVGT PTHASSVYCI
IKRKIRPLDV MTCQASNEDG STRLEFACTG VSYGIGSDIA VESEATRWLG VHRYFYLKVK
RGIFAPHKHE AKISYVLSDN VPVDPNTGEQ ILRTYYEIMD DTAEDQHHVE RCSIYDDSDP
AAKQWKGDAE SIFHPASEEK YTGKWQSFSS ELTSAGGSNV YFETKYAHPS DGNLDLIYSR
KGNIMQTAEI AVRYLSNTFL KSELVGYHKV KAMVIEPIVE DVLNVDGEVF AGPGPFRIEV
VPQLLCVLSE K
//
