ID A0A0W8C1L1_PHYNI Unreviewed; 855 AA.
AC A0A0W8C1L1;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 27-MAR-2024, entry version 34.
DE SubName: Full=Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 {ECO:0000313|EMBL:KUF77983.1};
GN ORFNames=AM587_10013418 {ECO:0000313|EMBL:KUF77983.1}, AM587_10017355
GN {ECO:0000313|EMBL:KUF87739.1};
OS Phytophthora nicotianae (Buckeye rot agent).
OC Eukaryota; Sar; Stramenopiles; Oomycota; Peronosporales; Peronosporaceae;
OC Phytophthora.
OX NCBI_TaxID=4790 {ECO:0000313|EMBL:KUF77983.1, ECO:0000313|Proteomes:UP000052943};
RN [1] {ECO:0000313|EMBL:KUF77983.1, ECO:0000313|Proteomes:UP000052943}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=race 0 {ECO:0000313|Proteomes:UP000052943}, and Race 0
RC {ECO:0000313|EMBL:KUF77983.1};
RA Liu H., Ma X., Yu H., Fang D., Li Y., Wang X., Wang W., Dong Y., Xiao B.;
RT "Genomes and virulence difference between two physiological races of
RT Phytophthora nicotianae.";
RL Submitted (NOV-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KUF77983.1}.
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DR EMBL; LNFO01005436; KUF77983.1; -; Genomic_DNA.
DR EMBL; LNFO01001974; KUF87739.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0W8C1L1; -.
DR EnsemblProtists; KUF77983; KUF77983; AM587_10013418.
DR EnsemblProtists; KUF87739; KUF87739; AM587_10017355.
DR Proteomes; UP000052943; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005249; F:voltage-gated potassium channel activity; IEA:InterPro.
DR CDD; cd00038; CAP_ED; 1.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 1.10.287.630; Helix hairpin bin; 1.
DR Gene3D; 2.60.120.10; Jelly Rolls; 1.
DR InterPro; IPR000595; cNMP-bd_dom.
DR InterPro; IPR018490; cNMP-bd_dom_sf.
DR InterPro; IPR003938; K_chnl_volt-dep_EAG/ELK/ERG.
DR InterPro; IPR014710; RmlC-like_jellyroll.
DR PANTHER; PTHR45689:SF13; CYCLIC NUCLEOTIDE-BINDING DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR45689; I[[H]] CHANNEL, ISOFORM E; 1.
DR Pfam; PF00027; cNMP_binding; 1.
DR PRINTS; PR01463; EAGCHANLFMLY.
DR SMART; SM00100; cNMP; 1.
DR SUPFAM; SSF51206; cAMP-binding domain-like; 1.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 1.
DR PROSITE; PS50042; CNMP_BINDING_3; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000052943};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 177..202
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 248..266
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 300..325
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 345..362
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 383..412
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 490..608
FT /note="Cyclic nucleotide-binding"
FT /evidence="ECO:0000259|PROSITE:PS50042"
FT REGION 671..768
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 803..848
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 697..726
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 732..755
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 803..817
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 855 AA; 97515 MW; 79658C96D5879F8E CRC64;
MGSMKGPSSD ISACSRVVPE GETAIREALT TSPVDNGIPT PEQEADVLSK LVSPLVPHDA
ALVTSDEHCP SATTDPNICL GPVLPDIRVP PVQENERNEE TNDAARKQIR QTNDPSIETI
KAIEFTEEAN KRRSWKVVGK LAVMAKSMNA HSIDIYHDRK LNTSRFMIHP NSKLRRAWEA
TTVCLVLYVC VMIPFIIGFQ FVDWSHLNGM NTFIDVYFIT DMVMTLRTGI VSNGEVVMDP
KRVAKKYFHS WFIVDLISNF PLVLFVQSSG KSLKIVKLQK IPKLLRIGRL LKYLREYAKY
YNLIVSFLGL AMGLHLFACI WASLFNECYD FHGELVCTEE ELAPMYVQCV HTIMLMFFGI
GESTTYSNIA RLKNPELNAN IELYYMSITV FMLGTIFSSF LFGNILALLM SWDQQKAQFR
NRMDMIKAEM KYYELPEELQ HRVRRNYDYL WINQRAYSDM MLLNQPGISK PLKTTIALHL
YKDLVKTVPF FAGSDSRFLG KVCLALETAV YLPGDTIIYC DDIGKEMFIV RKGLVEILID
PENSEKRIYL RDGNFFGETA LVIDVRRTNT VRAVNICDLN VLSKHAFNEI AAEYPEFGER
MKRTVIKRQL DNMNIQSPTE KAKIHNQLTL VVEKSLKQRR MSVSLRTIYR AKKLGDKLKE
IADRASKPVR RFSRAVAPRQ ARIRPSQRED SHFKSSMESS FADSTRDLAQ FSRPVSGSSS
RNLFPKRPTV THRMNSGLSR QASQSGATET TGPRRTIDSG PRRTEVPSDL IPSALAQITT
MVEQIRQTTE LLSLRLGAVD DYDEEEEDDD FDEDTYSEDM SFNLRDTPPF PPLTEESEEE
MARRESNSIV RILIQ
//
