ID A0A0W8C880_PHYNI Unreviewed; 6139 AA.
AC A0A0W8C880;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=Protocadherin Fat 4 {ECO:0000313|EMBL:KUF80302.1};
GN ORFNames=AM587_10016961 {ECO:0000313|EMBL:KUF80302.1};
OS Phytophthora nicotianae (Buckeye rot agent).
OC Eukaryota; Sar; Stramenopiles; Oomycota; Peronosporales; Peronosporaceae;
OC Phytophthora.
OX NCBI_TaxID=4790 {ECO:0000313|EMBL:KUF80302.1, ECO:0000313|Proteomes:UP000052943};
RN [1] {ECO:0000313|EMBL:KUF80302.1, ECO:0000313|Proteomes:UP000052943}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=race 0 {ECO:0000313|Proteomes:UP000052943};
RA Liu H., Ma X., Yu H., Fang D., Li Y., Wang X., Wang W., Dong Y., Xiao B.;
RT "Genomes and virulence difference between two physiological races of
RT Phytophthora nicotianae.";
RL Submitted (NOV-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KUF80302.1}.
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DR EMBL; LNFO01004578; KUF80302.1; -; Genomic_DNA.
DR STRING; 4790.A0A0W8C880; -.
DR EnsemblProtists; KUF80302; KUF80302; AM587_10016961.
DR OMA; FGCFPND; -.
DR Proteomes; UP000052943; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IEA:InterPro.
DR CDD; cd11304; Cadherin_repeat; 33.
DR CDD; cd00603; IPT_PCSR; 1.
DR Gene3D; 2.60.40.60; Cadherins; 32.
DR Gene3D; 2.60.40.10; Immunoglobulins; 3.
DR InterPro; IPR002126; Cadherin-like_dom.
DR InterPro; IPR015919; Cadherin-like_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR014756; Ig_E-set.
DR InterPro; IPR002909; IPT_dom.
DR PANTHER; PTHR24028; CADHERIN-87A; 1.
DR PANTHER; PTHR24028:SF310; STARRY NIGHT; 1.
DR Pfam; PF00028; Cadherin; 8.
DR Pfam; PF01833; TIG; 2.
DR PRINTS; PR00205; CADHERIN.
DR SMART; SM00112; CA; 31.
DR SMART; SM00429; IPT; 2.
DR SUPFAM; SSF49313; Cadherin-like; 30.
DR SUPFAM; SSF81296; E set domains; 2.
DR PROSITE; PS50268; CADHERIN_2; 33.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000052943};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 5522..5542
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 5608..5631
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 5643..5662
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 5705..5727
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 5773..5793
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 5799..5815
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 5917..5936
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 5956..5983
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 5..107
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 132..225
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 224..327
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 326..433
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 432..536
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 535..640
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 648..744
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 745..863
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 864..964
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 965..1090
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1071..1179
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1178..1296
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1294..1396
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1428..1497
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1497..1605
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1611..1726
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1726..1830
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1855..1949
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1951..2059
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2060..2169
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2197..2279
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2279..2378
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2412..2484
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2617..2724
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2729..2821
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2822..2929
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2929..3037
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 3036..3139
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 3147..3239
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 3365..3471
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 3473..3579
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 3580..3691
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 3692..3802
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT REGION 6002..6040
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 6060..6139
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 6002..6022
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 6074..6088
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 6109..6139
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 6139 AA; 664363 MW; 66C875E9C964E817 CRC64;
MVCYVAENTP TGSPICAIPA SDPDRSELAT GKLVYYLAQS SNNGEDTTFQ IDPISGMLQV
ANSTLLNFEV RQKLVVTVCA RDGGSPSLIG CGTTTVYITD INDAPATITP QKCEIDEYIY
DYTDEQVGRL VGTAVCNLTV LDEDNSGSAN TSWKNHVWQV VEADSGCPFN VSAQGQVVVS
TPRSVSYEQQ KVWSLLVQAM DLGGLSSTPQ RIEISILDIN EKPQINATTF YIDENSVAGT
LATGIISVFD PDIRSDGQSD TPIVSLVEEV DTFNVANNKI QLQRDTLDFE TKPSYVISVV
ATDQSGAKSN VQKINIVVNN VNEGPTIDPM QVSILENQPA MTKILPAVKA KDPDGDSVSF
SLVSETPQGA ITRAPTAFGI DTITGVLFQQ VDQLNYEEAK EYALVVKARD TAGLFSTAIV
TVIITDVNEA PSIRDQTVSI RENVSIVASV GQPFATMSSD PDLKNGLEVL TFTLTNASQS
PFSIDSKSGQ VXTSAHLDFE TVSVYNLRVR VMDLNGLSDE SNFMVTILDV NEPPVIGPFS
ISVPENLVPG SILGDPIVAI DPEAGSKLYY DLIGTSDIVT ACIRINSSTG QLSLKIDCSL
DYEASTGSTL SVVVHVTDGE FTVSTKGTIY IIDVNEAPVL VASESTLLRE NSVDETIVTL
IVVEDPDVNE YHQFWICEQS HSNTFRIQPT GLNTAEIVVM DSSVLNYEKN PYLCVDACVK
DRGNLTAKAR YTINLVNVFE PPYFVQDIIQ FTVEESIRVG SDIGSPLTRL VIDEENLNVD
IGCSVEISIV NSTCGHRASF SVDSCGQITL SSGGLDYETM STCVVYVLLP ATSIYNANTS
SLPLVDTITV VLTVTDVNEP PAFQQNLYQF GLAESSGEGA LIGVLPATDV DTGDVLSFQL
LNVETGYEGV FKVSVSGEIT LAGLLDYEKK QSYQVSVRVL DRQGAYSDSS VVISITDTEE
PPIFQASHYS FAIRENSPVQ TVVGDVVAID SDTYQNKTII YNIISGNNFG AFAILSIAGD
GKIVVGSQQA LDYERQESYT LLVEATDSIQ GGVRSFATVS VSIKDVNEAP QVHPVRVYIP
EDAVIATPIF SSSALNETFT GKLFASDPDD KDTLTFXATD STDTFSIDSV SGAVLSKRLL
NFESNSYYSI YITATDEDNL SATEILEIII LDRNDVPIVT STTFTLAENQ LRDSVVGVTQ
ITDEDFNQQH FFTLVETTLV LRDNSTEVRP NNDVVSVGLS SGSIQVLNES VFDYEVVRQV
VIVITVSDDG NPIRQSAGSL TIDLTNENEQ CAFPEVVLTL SISENVIGVA GHVLAIDPDA
NTSLSWGSLS YYMIDDEMSS NAVSLSNTGE VLVKTPLDFE IQRKIVFKVA AVDGGSLVCS
TSVQLLVEDK NEPPVIQSDH FWVPESVDGN LDWVRAYDGS HARILVWDPE NDTVTVSQNS
SDYISVSDDG LIYLEKPVNY EVKSCYDLLV TATDSHGLQT SAIVRVEIVD LNEPPVFTPQ
PTLTIAEDAS RGAVLGVVGS AYDPDEYDVV SYKLESATDR NGLSVDMFMI HSCDGEVRMS
KSSALDYEAN DRYVLTISAA DRAGLKAFSK PLLVEVTDVN EPPQCRDEIL SILENATANE
RFGPIEWSDP DSPIKNNITV FEVISDTDEI GYEIFEIQWG NDQYWMALQN SGRLDYESMN
LYTVRVKIGD SFDSRNDPSA TSVVSSLSST CTITIHVLDV NEPPIVSSII KREVEENAPL
YVNVGLPIEV NDPDAADVLH YSNANHQTNP VPFTMDYNTG QLRVSGDLDY ETQALYSINV
IIEDSALNTI TTLLEVSIID INERPQLPRN CFVREDGITE NRYEYNKDVC IEANEDVEVG
ALLHHFEALD PDSNQRLFYS VSETSNPFVR VVQNDDRSCE LIYSRAIFDY ESLKMHRVQL
TVTDTGKGFL SDTVMVFIFI VDVNEPPSLL QASTLNLVIA ENSVSGQLLG QLHGVDPEGD
SFTFSLKGSS PVSNTIEIRD DGQIRTTGAS IDYEALAKMN SLWAEPVLTI RGTINSFDAV
STAFTFVIAV VDVPEPPSFS FKQYSLAVHE LASAGVIVGA LQATDPDFND TQRFTWDTTD
AATKAASSVF DVDDKFGIIS LIKKGVLDSE TTPTYKLKTV VTDSTGLTDL STVVLTIVND
NEPPSCPSLQ CWVLENAAGV FKGLPGTQGL CQAEVQDLDI GQKHTFQLLS YPDSSIFSID
YASGVVRFTS GQQIYXNFEV QSVYRLRYQT NDIPDTGVSL SCSNEIVISV VDVNEAPAIS
GRQSLIVAEM STDGTIVGTV NTIDEDNGDV LTFSLLDSYS PFTLETDTGV LRVANGSTIN
FESAPVMYIT VAVTDREGLQ VVATLTVTVL NVNDPPILQS ANFTAAEYAL SRNGDTFGTR
NLELLGSLHC FDEDTSDELS FSLLDDTSAF VVETKSGMFY AETRNLDFET TRGYALTIQC
SDGQTTAIST FWVFVKNINE APIVTGQVYR VNENTPIGTG IGFVSVSDVE HDDENFLTIV
NDATRSSNTV SRLQDQAPVF TDSLDVEWMN IPEILQNAFI VTTSVSEPLS KVTLNLASSG
DIFVLVEDDS DVIPAWISQN AFVKLEGQTI TAQSSTSATT YEIYIRANSG GDFVIPDTTA
FNMLCVFGAY PSPLEYFIHG SRSNWFDVST SGELLLATVT LDYESIAAID QPVQISVNVV
DSGGLMGEAT LSIYVDDVNE PPVIISCCFE ITENPTIGSM IGELSGTDPD LSDQITFELA
FPSTDISLTS SGNMSVRDSS LFDYERNSLX TVRVRATDRG GLVYEREIQI KVLDVNEPPI
FQQSSYYFGV PENSASGLNF GTPIRAIDPD RGQTENLRYE LVNKNDGGLP FRLESCSGQL
AVQWDKLDYE GTNQYSFGVR VIDSGYPVAL EAQVQVVVDI LNVNEPPQFA ESGSLVILEN
APTGTFIGKI IATDPDQASV LTFRTNASNY VSITDSGELY AAEPFDYETM PILFISITVK
DSSVYCDPTL DAASCKSMST IMNAVVLIRN VNEPPSLTAG TFTILENLSP GSLVGXPVKV
VDVDGTVGXX SGFWIKSGVS SGNASEFLIR SDGQLLTLVP MDFESKTEYE LEIAYTDGEF
TSFLDIKVSV LDENEPPSVV GGITGYVQEN KPAGTTVLVA QFTDPDQTSA NVFTLMDSYV
PFRMDQLSGV LQTTRALDYE KDPTTFNLNV RVCDAAHTSL CGSGFVTVNV LDVHEAPSMD
DLICTQVENT AVVLTEQGAS ACTFIAIDPD KASCSFYSIV GSTSSYQLVH DTIVNGVATT
KMLEPTLCTS GRVGLSWKAS SLPDYEVLSQ HVVTVRVSDE TVKTTGFSAD SRVIVNIVNA
NDCPTLAALS FTVRERSAAG TQIGYPLPGK DQDVADTLTY SIVKSNATSG LIGIDAMTGQ
LTAARAPSGS ELVYPAQYTV TVSVTDSSVS RCSTTADIKV FTTKSNFAPV WSSTLPASFD
INENSATGTQ AGALISGFVE DPDNDVIQFT LQSKTDAYCA DTFSVGLTSG AIALRAGIVL
DFEQRRTYIC TVAACDPFQM CSTHDVTVQV KNVNEAPVFN DQQYKFVVQE NKAPNLALPR
CLSATDPDEG DGYALTYTTS CTNATDCSLF SVKVEKDCSQ ARCARIIVKL SLNYEARRHY
SFNLIAQDPG KLTAVTIIVI EVEDVNEIHS FVDFTTTKSV LENTAIGSAI LRVTTTDPDM
YSYPFGTIQY ALSGMTPPGL NVFRIDSTTG DLIVNGAIDF EAVQAYTLTI EARDSSGINA
LVISKDLIVT VKNTEDTTVE AFELVADSSR KLSTIGGEKF ILTGTNMGFK QRADGSVVIK
LLTVQYGAYG TTSPYTATNC FLVNGNTGVE CTSAPGVGAN LYWNITLVMT VPTIGDTTFQ
ASSSVPLASY GAPVIDSIEC NTAFPTNGSS VDNIIIYGEN LGSTQLSSSD AQPIVLYGSD
FEVQNCKLHT STRQYVICRS VLGTGTNLPF TLVVRGQASA TFATSCHYAA PIITAVTMAN
GLQTSGSATV VVNGSGFGCQ GCANITVWYM NTLHSSELND CTVVVDHIQL TCMSLPGAGG
DFQWQISVDN QLSVLTSEIK TAYDLPQILE VMGFKDASTA GGTVFQIRGQ NFGPDTAIFV
DPVVEYSFDN LTILRAVHCK RXYTDPKNHN LIQCESVAGS GSFHSWRVTI EGQTSLWTTQ
NTSYAGPIVN KVFRPDGEAE IRTSGAQQVV ITGKNFGIMN ESVINRVTYG INGNEFTATN
CSIVINHERI LCTTAPGVGN RLAWIVTIDG LTSATPTISY AKPYITSLDG EGAVNALVRG
GQTVIIRGGN FGPSDVAIDI ISYGSSGRDY QVTEVIKHND STIVCTTTPG VGANLSWIVS
VGDQESSLST FTSSYAPPVV TSFYPTVALT DGSTQVTIIG ENRGANVTFA ASRMMFSPPQ
SSLSTRRIPT IAFGDFGNSN SSEYVVVRVP VGYGSGGSLQ LLVGTTSVQK SALLPISYGL
PLIESVFTDE GPSECLPSCI QLTITGTNFY TTGRVLVSKY PVTTSNFEAA SYESSVDFSS
WTHDTIIIPK YVGKLGYVTI VIGREKILSN SAPFSWDDPS ILDWYTYSST CGVLDCSTSY
RLDGDTKLFQ TEPIGTTGEL NYLSATNGGA TLSLYAKYVG RNPRISIGGS TCNNVVVTTP
VIPSSVVLSG AISGVSSIRL ISCSVPSGQG SMLALIVTRG TTLSSPRYFS YIPPSVDWVG
SSATLSPTTG KMVTLTGANF GTNPIVSMTS SSNASALLTI TTFDHSHATV NIPAGEGQNY
TLKLIAGNQE KSTTFSYNPP VISSIEVVDA TTAGGSTMTI RGENFGTRAL SNEHAVSLGD
AFSCSIDSID HDLILCTTSE GQGSGHDVVV TVSGHANVDK TKKFSYDPPV VYSISRNDGP
TSGYTCSCTD PDQPCATLEA PIKCQYLEAS STSSSLDSYC VQTILDGVLQ KVTLTVVEDV
YSSNKAVYLS EETDLQLLYT GGFWQLLQND ESLYRASAST VSPPTTGWLD VTVDPPVDAT
MKVYPGSCSK TASRACPVGT ELCERVAVTI VGKNFGVRSL GWHLELASSD GSIEPVKVTN
DDIVYFSHST IKFNLPPGQG ISRIVNLTVS ELQLVNKSVE FDYQTPELIG YETSTSNLST
CGGYTITLYG KNFGSARAKV LIGGRDARVD GQSSHPKACG SDTCEYSSSG PCIDIDTLVC
YPSLYVVSPT FNFLDLCDDD KGTQIMCEAV DPAVDLAENL TSHSDFVIET TVPAGYGADL
EVYVVVDSQP SNALTFSYNQ PVITAQMPNQ PDANGANAIT IKGTDFGCFP NDAITISFAS
TDTVQPISRK LGAASSMSDL ETAFHGESYR QLAETTTPAD ATNTSSNSTG TIVWNSSSEL
IWYPPKTKAG ITSITLSVGG NVMSASSQTQ LKFQCSPGYY RTSTEFCDEC PEGATCAGGD
EMPLAKPGYW REGEVVFACD PMYACLGANR CAVGYMDIRC GECEKNYHKL NAECNLCPDN
KWGSVAIVVI CLGVASIVSY LLTRKGVSLG LLSIGIDYFQ TLSIFGNARI SWPASLINLF
STLSAFNLNL ELIAPECFAF QVSFVNKWFI IELFPLVVAA TSLGIFAALY AYKRFIKRRR
TRLTSHLPQL FGSTLVMMYY LFLYLTRTTL DVFNCVGTIP SDGKLYMVAI YTQCFKPGGI
HMQLFPFAVL AFVVYSLGYP LFVLLTLSRN RALVMEDQLL RAMQRGTSRR TNPNCWVFRK
KFSKLYYQFK PDYWYWMVLI ILRKFLLAGI GLLFRQDPVF QLATATFVLF VNYALQVRCR
PYMSAYETQR VLADYAKRVL LETRRAKAKG EAFIQPAHLR LEMHASTVTA WKSGHGDHGG
SGVAGSAASP GIRGANEAIL ASQEPQNLVG YLWDHNTVEA CLLFSASLVL LAGVMFESGR
LGSSETGFTS ASAQMLAIAT TMLVVVSCVY FALVLITELV VALRPDYYKR ITRVQKVFSS
PRRHLKDDTE TDHSKHRPAG DDDSDNDDDD ELEMVATMTQ NPLHFNRALA GARGRAMRAR
ERDALAALQD IQRRGSNPRR NSPQHQSERG VLSDEENVSR RRRSQRRRGT KRDENLMAEL
TSAIEETDDV NKQRRGADD
//
