ID A0A0W8CDK4_PHYNI Unreviewed; 596 AA.
AC A0A0W8CDK4;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE RecName: Full=HECT-type E3 ubiquitin transferase {ECO:0000256|ARBA:ARBA00012485};
DE EC=2.3.2.26 {ECO:0000256|ARBA:ARBA00012485};
GN ORFNames=AM587_10012569 {ECO:0000313|EMBL:KUF82185.1};
OS Phytophthora nicotianae (Buckeye rot agent).
OC Eukaryota; Sar; Stramenopiles; Oomycota; Peronosporales; Peronosporaceae;
OC Phytophthora.
OX NCBI_TaxID=4790 {ECO:0000313|EMBL:KUF82185.1, ECO:0000313|Proteomes:UP000052943};
RN [1] {ECO:0000313|EMBL:KUF82185.1, ECO:0000313|Proteomes:UP000052943}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=race 0 {ECO:0000313|Proteomes:UP000052943};
RA Liu H., Ma X., Yu H., Fang D., Li Y., Wang X., Wang W., Dong Y., Xiao B.;
RT "Genomes and virulence difference between two physiological races of
RT Phytophthora nicotianae.";
RL Submitted (NOV-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine +
CC [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-
CC cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.;
CC EC=2.3.2.26; Evidence={ECO:0000256|ARBA:ARBA00000885};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KUF82185.1}.
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DR EMBL; LNFO01003805; KUF82185.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0W8CDK4; -.
DR STRING; 4790.A0A0W8CDK4; -.
DR EnsemblProtists; KUF82185; KUF82185; AM587_10012569.
DR OMA; CAGVQFE; -.
DR Proteomes; UP000052943; Unassembled WGS sequence.
DR GO; GO:0004842; F:ubiquitin-protein transferase activity; IEA:InterPro.
DR Gene3D; 3.30.2160.10; Hect, E3 ligase catalytic domain; 1.
DR Gene3D; 3.30.2410.10; Hect, E3 ligase catalytic domain; 1.
DR Gene3D; 3.90.1750.10; Hect, E3 ligase catalytic domains; 1.
DR InterPro; IPR000569; HECT_dom.
DR InterPro; IPR035983; Hect_E3_ubiquitin_ligase.
DR PANTHER; PTHR11254; HECT DOMAIN UBIQUITIN-PROTEIN LIGASE; 1.
DR PANTHER; PTHR11254:SF446; HECT-TYPE E3 UBIQUITIN TRANSFERASE; 1.
DR Pfam; PF00632; HECT; 1.
DR SMART; SM00119; HECTc; 1.
DR SUPFAM; SSF56204; Hect, E3 ligase catalytic domain; 1.
DR PROSITE; PS50237; HECT; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000052943};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786,
KW ECO:0000256|PROSITE-ProRule:PRU00104}.
FT DOMAIN 250..595
FT /note="HECT"
FT /evidence="ECO:0000259|PROSITE:PS50237"
FT ACT_SITE 557
FT /note="Glycyl thioester intermediate"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00104"
SQ SEQUENCE 596 AA; 67771 MW; A0B4C4B1DCE77C5C CRC64;
MILTTYVATT NCGNWHRKLT TLHSKHCNSE QMADLRVIAA QREAERGFAT CVSCGFKNFA
RVLHCALCGN SSTDSKLPAT VLPSVNDPRE DVALPRRWEW TRELDVHDRL VWRRRLAEGG
DCSPGYVLRF DLPPETEPEA EREVSKHRQR SLSTGYDPCA DVQFELLEPR DVDPTQFPLP
PPRTDMSDTM EDLKHTAVHV AAQDFPTKYA HFVASATSLI QAGDRSVRSC LSVHRDYILE
QSVQHINCIR EESIRSVRLQ VNFAGHEDLP SDEKDVSGLH RGWMTLLNEK LVDPDVGLFL
CTQRSDQTFF INPQSKLVLG EDHLQHFNAA GRLIGRALLE GSVLNFHLCA PLLKMMLGTP
ITFGDLEFLD AEIYRNLTWL LDNDSAESLE LDFTVTQRHG NLAQTIELIP AGRNIQVNDD
NKFEFADRKF RFMMFECVAP QLASFLKGFY DVVPQRMLLP FNYEELDYLL CGSDEIDIAD
WRLHTHLALE SRQEVTWFWD VVKEMSRVYQ KRLLQLATGC SRVPLVGFQG LTSYDGQLCK
FTLTDAVGVA YFRSHACHNM LELPYFETKD DLRAALYAAL YNESSAADTK ALNTVP
//