ID   A0A0W8CXP1_PHYNI        Unreviewed;       411 AA.
AC   A0A0W8CXP1;
DT   16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT   16-MAR-2016, sequence version 1.
DT   27-MAR-2024, entry version 24.
DE   SubName: Full=2-dehydropantoate 2-reductase {ECO:0000313|EMBL:KUF88913.1};
GN   ORFNames=AM587_10011392 {ECO:0000313|EMBL:KUF88913.1};
OS   Phytophthora nicotianae (Buckeye rot agent).
OC   Eukaryota; Sar; Stramenopiles; Oomycota; Peronosporales; Peronosporaceae;
OC   Phytophthora.
OX   NCBI_TaxID=4790 {ECO:0000313|EMBL:KUF88913.1, ECO:0000313|Proteomes:UP000052943};
RN   [1] {ECO:0000313|EMBL:KUF88913.1, ECO:0000313|Proteomes:UP000052943}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=race 0 {ECO:0000313|Proteomes:UP000052943};
RA   Liu H., Ma X., Yu H., Fang D., Li Y., Wang X., Wang W., Dong Y., Xiao B.;
RT   "Genomes and virulence difference between two physiological races of
RT   Phytophthora nicotianae.";
RL   Submitted (NOV-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the ketopantoate reductase family.
CC       {ECO:0000256|ARBA:ARBA00007870}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KUF88913.1}.
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DR   EMBL; LNFO01001760; KUF88913.1; -; Genomic_DNA.
DR   STRING; 4790.A0A0W8CXP1; -.
DR   EnsemblProtists; KUF88913; KUF88913; AM587_10011392.
DR   OMA; QCTELAW; -.
DR   Proteomes; UP000052943; Unassembled WGS sequence.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR   InterPro; IPR013328; 6PGD_dom2.
DR   InterPro; IPR013752; KPA_reductase.
DR   InterPro; IPR013332; KPR_N.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   PANTHER; PTHR43765; 2-DEHYDROPANTOATE 2-REDUCTASE-RELATED; 1.
DR   PANTHER; PTHR43765:SF2; 2-DEHYDROPANTOATE 2-REDUCTASE-RELATED; 1.
DR   Pfam; PF02558; ApbA; 1.
DR   Pfam; PF08546; ApbA_C; 1.
DR   SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000052943}.
FT   DOMAIN          42..224
FT                   /note="Ketopantoate reductase N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF02558"
FT   DOMAIN          278..402
FT                   /note="Ketopantoate reductase C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF08546"
SQ   SEQUENCE   411 AA;  45117 MW;  7C3B79DFD8FD734E CRC64;
     MLRICSRNPS AYRSVGRSIY SVSCLQNVME EVGTNRSNEL RVGVLGLGAI GTIFFTRLGR
     LAASVKAKRE LPTLTVDAFV KAERFENWTR NEKLQLCLQV SNEETLAFRL DDLNEKVATV
     LDAPNVRVRT LDSVVADDCX GKLDVLLVAV KAYDNVKVIH ELREKSKHLM KDGALCVLLQ
     NGLGEVPRDG ENALDRVEDR WEFANGVTFV GGRVVEFGSV VTSGLDVGMT YLAPFGGSEE
     EKQRSTKIEM LTEIFLAAEL IVVLHEGLRC EILEPSKMQA MLWRKLIVNA AINPLACLLN
     APNKSVASSE GSRHCVNMVV QEALAVAKSE QIPLSCSQKE LVDDILEVAR NTGTNVCSML
     ADLRRGSKTE IDAITGRIVA GGKRQGIPTP TNEMLLSLIK ALXEEGTRRI E
//