ID A0A0W8D288_PHYNI Unreviewed; 541 AA.
AC A0A0W8D288;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 22-FEB-2023, entry version 20.
DE SubName: Full=Glucosylceramidase {ECO:0000313|EMBL:KUF90525.1};
GN ORFNames=AM587_10016659 {ECO:0000313|EMBL:KUF90525.1};
OS Phytophthora nicotianae (Buckeye rot agent).
OC Eukaryota; Sar; Stramenopiles; Oomycota; Peronosporales; Peronosporaceae;
OC Phytophthora.
OX NCBI_TaxID=4790 {ECO:0000313|EMBL:KUF90525.1, ECO:0000313|Proteomes:UP000052943};
RN [1] {ECO:0000313|EMBL:KUF90525.1, ECO:0000313|Proteomes:UP000052943}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=race 0 {ECO:0000313|Proteomes:UP000052943};
RA Liu H., Ma X., Yu H., Fang D., Li Y., Wang X., Wang W., Dong Y., Xiao B.;
RT "Genomes and virulence difference between two physiological races of
RT Phytophthora nicotianae.";
RL Submitted (NOV-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 30 family.
CC {ECO:0000256|ARBA:ARBA00005382}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KUF90525.1}.
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DR EMBL; LNFO01001539; KUF90525.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0W8D288; -.
DR STRING; 4790.A0A0W8D288; -.
DR EnsemblProtists; KUF90525; KUF90525; AM587_10016659.
DR OMA; VWMTTEN; -.
DR Proteomes; UP000052943; Unassembled WGS sequence.
DR GO; GO:0004348; F:glucosylceramidase activity; IEA:InterPro.
DR GO; GO:0006665; P:sphingolipid metabolic process; IEA:InterPro.
DR Gene3D; 3.20.20.80; Glycosidases; 1.
DR Gene3D; 2.60.40.1180; Golgi alpha-mannosidase II; 1.
DR InterPro; IPR033452; GH30_C.
DR InterPro; IPR001139; Glyco_hydro_30.
DR InterPro; IPR033453; Glyco_hydro_30_TIM-barrel.
DR InterPro; IPR013780; Glyco_hydro_b.
DR InterPro; IPR017853; Glycoside_hydrolase_SF.
DR PANTHER; PTHR11069; GLUCOSYLCERAMIDASE; 1.
DR PANTHER; PTHR11069:SF23; LYSOSOMAL ACID GLUCOSYLCERAMIDASE; 1.
DR Pfam; PF02055; Glyco_hydro_30; 1.
DR Pfam; PF17189; Glyco_hydro_30C; 1.
DR PRINTS; PR00843; GLHYDRLASE30.
DR SUPFAM; SSF51445; (Trans)glycosidases; 1.
DR SUPFAM; SSF51011; Glycosyl hydrolase domain; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Reference proteome {ECO:0000313|Proteomes:UP000052943};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 23..541
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5006941157"
FT DOMAIN 103..464
FT /note="Glycosyl hydrolase family 30 TIM-barrel"
FT /evidence="ECO:0000259|Pfam:PF02055"
FT DOMAIN 467..530
FT /note="Glycosyl hydrolase family 30 beta sandwich"
FT /evidence="ECO:0000259|Pfam:PF17189"
SQ SEQUENCE 541 AA; 60340 MW; 9D2AD799035FD4BF CRC64;
MLAPYLLTTL AGLLLATQEA SATCSNWSTR YQTNLNGVCV CNATQCDTVS NNYTSLTTGQ
VGVYTTSKAG DRFAYKVANV DSTTVSSPTY SIDVSTQYQT MIGFGGTFTD AAAINVYKLS
SKLQQMVLDQ YFSDTGLQYT LGRVPIGSTD FSTSIYSYND VVDDFEMEHF SINVDKSSSS
HKIELIQRAL NTTSRDIKLF ASSWAPPVWM TTENTTINCA LKGNPGEEYW EALALYYSKF
FDAYSEEGID FWAMTVQNEP SSSILQTSEW QSLRLTADQE RDFVKLDLGP RMAKDHPDLK
IIAGDDQKSG ILDRLAPFED ADALKYISGL GVHWYRDLDF FFFSLGGDFD KLLSFYEDYP
DIFMLATEAC EGYLPSWLGT GSGVSLTDAD KSWSRAENYG HDIIEDLNNY VAGWTDWNLA
LDTTGGPNWA ENYVDAPILV DEENGVEFYK QPMFYIMGHF SKFVPAGSKR IEFPKTKTLS
SFHRCAFVTP DNRVVIQFMN RDSSAVTVSV KQTDSKTFTL SLPAHSMQTV ILPASDDTTI
L
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