ID A0A0W8D5P6_PHYNI Unreviewed; 702 AA.
AC A0A0W8D5P6;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE SubName: Full=Methylcrotonoyl-CoA carboxylase subunit alpha {ECO:0000313|EMBL:KUF78882.1};
GN ORFNames=AM587_10004588 {ECO:0000313|EMBL:KUF78882.1}, AM588_10003657
GN {ECO:0000313|EMBL:KUF91468.1};
OS Phytophthora nicotianae (Buckeye rot agent).
OC Eukaryota; Sar; Stramenopiles; Oomycota; Peronosporales; Peronosporaceae;
OC Phytophthora.
OX NCBI_TaxID=4790 {ECO:0000313|EMBL:KUF91468.1, ECO:0000313|Proteomes:UP000054636};
RN [1] {ECO:0000313|Proteomes:UP000052943, ECO:0000313|Proteomes:UP000054636}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=race 0 {ECO:0000313|Proteomes:UP000052943}, Race 0
RC {ECO:0000313|EMBL:KUF78882.1}, Race 1 {ECO:0000313|EMBL:KUF91468.1},
RC and race 1 {ECO:0000313|Proteomes:UP000054636};
RA Liu H., Ma X., Yu H., Fang D., Li Y., Wang X., Wang W., Dong Y., Xiao B.;
RT "Genomes and virulence difference between two physiological races of
RT Phytophthora nicotianae.";
RL Submitted (NOV-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=biotin; Xref=ChEBI:CHEBI:57586;
CC Evidence={ECO:0000256|ARBA:ARBA00001953};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KUF91468.1}.
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DR EMBL; LNFO01005122; KUF78882.1; -; Genomic_DNA.
DR EMBL; LNFP01000576; KUF91468.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0W8D5P6; -.
DR STRING; 4790.A0A0W8D5P6; -.
DR EnsemblProtists; KUF78882; KUF78882; AM587_10004588.
DR EnsemblProtists; KUF91468; KUF91468; AM588_10003657.
DR OMA; FINKPKH; -.
DR OrthoDB; 1129179at2759; -.
DR Proteomes; UP000052943; Unassembled WGS sequence.
DR Proteomes; UP000054636; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016874; F:ligase activity; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:InterPro.
DR CDD; cd06850; biotinyl_domain; 1.
DR Gene3D; 2.40.50.100; -; 1.
DR Gene3D; 3.30.470.20; ATP-grasp fold, B domain; 1.
DR InterPro; IPR011761; ATP-grasp.
DR InterPro; IPR005481; BC-like_N.
DR InterPro; IPR001882; Biotin_BS.
DR InterPro; IPR011764; Biotin_carboxylation_dom.
DR InterPro; IPR005482; Biotin_COase_C.
DR InterPro; IPR000089; Biotin_lipoyl.
DR InterPro; IPR005479; CbamoylP_synth_lsu-like_ATP-bd.
DR InterPro; IPR016185; PreATP-grasp_dom_sf.
DR InterPro; IPR011054; Rudment_hybrid_motif.
DR InterPro; IPR011053; Single_hybrid_motif.
DR PANTHER; PTHR18866; CARBOXYLASE:PYRUVATE/ACETYL-COA/PROPIONYL-COA CARBOXYLASE; 1.
DR PANTHER; PTHR18866:SF33; METHYLCROTONOYL-COA CARBOXYLASE SUBUNIT ALPHA, MITOCHONDRIAL-RELATED; 1.
DR Pfam; PF02785; Biotin_carb_C; 1.
DR Pfam; PF00289; Biotin_carb_N; 1.
DR Pfam; PF00364; Biotin_lipoyl; 1.
DR Pfam; PF02786; CPSase_L_D2; 1.
DR SMART; SM00878; Biotin_carb_C; 1.
DR SMART; SM01209; GARS_A; 1.
DR SUPFAM; SSF56059; Glutathione synthetase ATP-binding domain-like; 1.
DR SUPFAM; SSF52440; PreATP-grasp domain; 1.
DR SUPFAM; SSF51246; Rudiment single hybrid motif; 1.
DR SUPFAM; SSF51230; Single hybrid motif; 1.
DR PROSITE; PS50975; ATP_GRASP; 1.
DR PROSITE; PS50979; BC; 1.
DR PROSITE; PS00188; BIOTIN; 1.
DR PROSITE; PS50968; BIOTINYL_LIPOYL; 1.
DR PROSITE; PS00867; CPSASE_2; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00409}; Biotin {ECO:0000256|ARBA:ARBA00023267};
KW Ligase {ECO:0000256|ARBA:ARBA00022598};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00409}; Reference proteome {ECO:0000313|Proteomes:UP000052943}.
FT DOMAIN 26..472
FT /note="Biotin carboxylation"
FT /evidence="ECO:0000259|PROSITE:PS50979"
FT DOMAIN 145..342
FT /note="ATP-grasp"
FT /evidence="ECO:0000259|PROSITE:PS50975"
FT DOMAIN 625..702
FT /note="Lipoyl-binding"
FT /evidence="ECO:0000259|PROSITE:PS50968"
SQ SEQUENCE 702 AA; 77364 MW; 0C5971D2008A15AD CRC64;
MLRLRLLQPA LLGPTSRRAL SSTPRSFRKI LVANRGEIAL RVLRSAQKLN IETVAVYSDA
DANSQHVKLA TEAYRLGPAP AAESYLNYPK ILEICRESGV EAVHPGYGFL SENAAFARAC
EEAGVEFIGP PVKAIEDMGS KSASKDIMIK AGVPVTPGYH GADQSFETLQ REAKKIGYPV
LIKAVLGGGG KGMRIVDEEK DFQDALDACV REGQASFGDG RVLIEKYLRK PRHVELQIFG
DKHGNVIHLF ERDCSVQRRH QKVLEEAPAP NMSEALRKKM GDAAVAAAKA VGYVGAGTVE
FLLDEDESFY FMEMNTRLQV EHPVTEMITK QDLVELQLKV AAGQELPIRQ EDLKIHGHAV
EARIYAENPY NDFLPGSGKL QHLRLPSRSK DVRVDTGIIE GDEVSIFYDP MIAKLIVHGD
NRQAALDKMI KALHEYQIVG LPTNIEFVAR TADHAAFRKG GVDTSFLNKF GDEVLGSLGT
YPTYAKALGA VSLLLLEQVK RRPAGNYNGE LQSPWSDDSL AHFRSLETLE RKLSLSHDDD
EASVSVKCLA KDTYAVILDG DAGQETHEVS GAIDKRGDFK FRVGNRTFKG TAVIHQQELH
LFCDDNSQRY DYKFHVPLPS FEPAEGSAGA AAHSKIAAPM PGKIIKVLVK NGDTITADQP
LLIMEAMKME HMIRAPKDGK VQELFCEKDD FVTDGHVLVE LD
//
