ID A0A0W8IEP5_9MICO Unreviewed; 393 AA.
AC A0A0W8IEP5;
DT 16-MAR-2016, integrated into UniProtKB/TrEMBL.
DT 16-MAR-2016, sequence version 1.
DT 24-JAN-2024, entry version 29.
DE SubName: Full=Pyruvate dehydrogenase (Acetyl-transferring) E1 component subunit alpha {ECO:0000313|EMBL:KUG58453.1};
GN ORFNames=AVL62_11170 {ECO:0000313|EMBL:KUG58453.1};
OS Serinicoccus chungangensis.
OC Bacteria; Actinomycetota; Actinomycetes; Micrococcales;
OC Ornithinimicrobiaceae; Serinicoccus.
OX NCBI_TaxID=767452 {ECO:0000313|EMBL:KUG58453.1, ECO:0000313|Proteomes:UP000054837};
RN [1] {ECO:0000313|EMBL:KUG58453.1, ECO:0000313|Proteomes:UP000054837}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CD08_5 {ECO:0000313|EMBL:KUG58453.1,
RC ECO:0000313|Proteomes:UP000054837};
RA Chander A.M., Kaur G., Nair G.R., Dhawan D.K., Kochhar R.K., Mayilraj S.,
RA Bhadada S.K.;
RT "Serinicoccus chungangenesis strain CD08_5 genome sequencing and
RT assembly.";
RL Submitted (DEC-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=thiamine diphosphate; Xref=ChEBI:CHEBI:58937;
CC Evidence={ECO:0000256|ARBA:ARBA00001964};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KUG58453.1}.
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DR EMBL; LQBL01000003; KUG58453.1; -; Genomic_DNA.
DR RefSeq; WP_058890130.1; NZ_LQBL01000003.1.
DR AlphaFoldDB; A0A0W8IEP5; -.
DR STRING; 767452.AVL62_11170; -.
DR Proteomes; UP000054837; Unassembled WGS sequence.
DR GO; GO:0000287; F:magnesium ion binding; IEA:UniProt.
DR GO; GO:0016624; F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor; IEA:InterPro.
DR CDD; cd02000; TPP_E1_PDC_ADC_BCADC; 1.
DR Gene3D; 3.40.50.970; -; 1.
DR InterPro; IPR001017; DH_E1.
DR InterPro; IPR017596; PdhA/BkdA.
DR InterPro; IPR029061; THDP-binding.
DR NCBIfam; TIGR03181; PDH_E1_alph_x; 1.
DR PANTHER; PTHR43380; 2-OXOISOVALERATE DEHYDROGENASE SUBUNIT ALPHA, MITOCHONDRIAL; 1.
DR PANTHER; PTHR43380:SF1; 2-OXOISOVALERATE DEHYDROGENASE SUBUNIT ALPHA, MITOCHONDRIAL; 1.
DR Pfam; PF00676; E1_dh; 1.
DR SUPFAM; SSF52518; Thiamin diphosphate-binding fold (THDP-binding); 1.
PE 4: Predicted;
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Pyruvate {ECO:0000313|EMBL:KUG58453.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000054837}.
FT DOMAIN 71..360
FT /note="Dehydrogenase E1 component"
FT /evidence="ECO:0000259|Pfam:PF00676"
FT REGION 1..30
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 393 AA; 43473 MW; 02F38CDBF40BC377 CRC64;
MSDDEVAPEG ATPTSHEPPE RDITDGGPDM VQFLAADGTR LEVTPQTEPY AAYLEDLDED
DLRGLLRDLI LVRRVDAEGF ALQRQGELGL WPSLLGQEAA QVGAGRAMRP QDYAFPGYRE
HGVAWCKGVP PENLLGMFRG VNHGGWDSND NNFHLYTIVI GNQMLHAVGY AMGVDRDGAV
GTGDPERDTA VMAFTGDGGT AQGDFNESLV FAAVTNAPVV FYVQNNHWAI SEPNDRQFTI
PPYRRADGFG FPGVRVDGND VLASYAVSRY ALDRARNGQG PTLIEAFTYR MGAHTTSDDP
TKYRISAEVD AWKAKDPIDR MTAYLRGRGV VDDAWLERTQ EEADELAARI RKACQTMPDP
PHEEMFAHVY AEPHRLIERE AQAFADYQAD FED
//
