ID A0A0X1T153_PSEAA Unreviewed; 862 AA.
AC A0A0X1T153;
DT 13-APR-2016, integrated into UniProtKB/TrEMBL.
DT 13-APR-2016, sequence version 1.
DT 27-MAR-2024, entry version 34.
DE RecName: Full=DNA mismatch repair protein MutS {ECO:0000256|ARBA:ARBA00021982, ECO:0000256|HAMAP-Rule:MF_00096};
GN Name=mutS {ECO:0000256|HAMAP-Rule:MF_00096};
GN ORFNames=AWM79_10910 {ECO:0000313|EMBL:AMB85783.1};
OS Pseudomonas agarici.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Pseudomonadales;
OC Pseudomonadaceae; Pseudomonas.
OX NCBI_TaxID=46677 {ECO:0000313|EMBL:AMB85783.1, ECO:0000313|Proteomes:UP000063229};
RN [1] {ECO:0000313|EMBL:AMB85783.1, ECO:0000313|Proteomes:UP000063229}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NCPPB 2472 {ECO:0000313|EMBL:AMB85783.1,
RC ECO:0000313|Proteomes:UP000063229};
RA McClelland M., Jain A., Saraogi P., Mendelson R., Westerman R.,
RA SanMiguel P., Csonka L.;
RL Submitted (JAN-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC It is possible that it carries out the mismatch recognition step. This
CC protein has a weak ATPase activity. {ECO:0000256|ARBA:ARBA00024647,
CC ECO:0000256|HAMAP-Rule:MF_00096}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC {ECO:0000256|ARBA:ARBA00006271, ECO:0000256|HAMAP-Rule:MF_00096,
CC ECO:0000256|RuleBase:RU003756}.
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DR EMBL; CP014135; AMB85783.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0X1T153; -.
DR STRING; 46677.AWM79_10910; -.
DR Proteomes; UP000063229; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR CDD; cd03284; ABC_MutS1; 1.
DR Gene3D; 1.10.1420.10; -; 2.
DR Gene3D; 6.10.140.430; -; 1.
DR Gene3D; 3.40.1170.10; DNA repair protein MutS, domain I; 1.
DR Gene3D; 3.30.420.110; MutS, connector domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR HAMAP; MF_00096; MutS; 1.
DR InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR InterPro; IPR036678; MutS_con_dom_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR NCBIfam; TIGR01070; mutS1; 1.
DR PANTHER; PTHR11361:SF34; DNA MISMATCH REPAIR PROTEIN MSH1, MITOCHONDRIAL; 1.
DR PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR Pfam; PF01624; MutS_I; 1.
DR Pfam; PF05188; MutS_II; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF05190; MutS_IV; 1.
DR Pfam; PF00488; MutS_V; 1.
DR PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 2.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF55271; DNA repair protein MutS, domain I; 1.
DR SUPFAM; SSF53150; DNA repair protein MutS, domain II; 1.
DR SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|HAMAP-
KW Rule:MF_00096}; Reference proteome {ECO:0000313|Proteomes:UP000063229}.
FT DOMAIN 691..707
FT /note="DNA mismatch repair proteins mutS family"
FT /evidence="ECO:0000259|PROSITE:PS00486"
FT REGION 805..825
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 617..624
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00096"
SQ SEQUENCE 862 AA; 96044 MW; 9D4CB17012B12F0B CRC64;
MNMSIFDLSS HTPMMQQYWR LKHQHPDQLM FYRMGDFYEI FYEDAKRAAK LLDITLTARG
QSAGQSIPMC GIPYHSLEGY LAKLVKLGES VVICEQIGDP ATSKGPVERQ VVRIITPGTV
SDEALLDERR DNLIAALLGD ERLFGLAVLD ITSGNFSVAE IKGWENLLAE LERINPVELM
IPDDWPQGLP AEKRRGTRRR APWDFERDSA HKSLCQQFSV QDLKGFGCET LTLAIGAAGC
LLSYAKETQR TALPHLRSLR HERLDDTVVL DAATRRNLEL DTNLAGGRDN TLQSVVDRCQ
TAMGSRLLTR WLNRPLRDLK VLTARQSSIT CLLESYRFEK LQPQLKEIGD IERILARIGL
RNARPRDLAR LRDALGALPQ LQDAMLELDA PHLKQLAVTT RTYPELAILL ERAIIDNPPA
IIRDGGVLKS GYDAELDELL SLSENAGQFL IDLEAREKAR TGLANLKVGY NRVHGYFIEL
PSKQAESAPA DYIRRQTLKG AERFITPELK EFEDKALSAK SRALAREKML YEALLETLIG
ELPPLQDTAA ALAELDVLSN LAERALNLDL NCPRFVDEPC MRISQGRHPV VEQVLTTPFV
ANDLALDDDT RMLVITGPNM GGKSTYMRQT ALIVLLAHIG SFVPAARCEL SLVDRIFTRI
GSSDDLAGGR STFMVEMSET ANILHNASER SLVLMDEVGR GTSTFDGLSL AWAAAERLAH
LRAYTLFATH YFELTVLPES EPLVANVHLN ATEHNERIVF LHHVLPGPAS QSYGLAVAQL
AGVPADVIVR AREHLSRLET TSLPHELSVT KPDRPSKPAT PMQSDLFASL PHPVLDELAK
LDLDDLTPRR ALEMLYTLKT RI
//
