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Database: UniProt
Entry: A0A0X3S4G3_9ACTN
LinkDB: A0A0X3S4G3_9ACTN
Original site: A0A0X3S4G3_9ACTN 
ID   A0A0X3S4G3_9ACTN        Unreviewed;       627 AA.
AC   A0A0X3S4G3;
DT   13-APR-2016, integrated into UniProtKB/TrEMBL.
DT   13-APR-2016, sequence version 1.
DT   24-JAN-2024, entry version 23.
DE   SubName: Full=3D-(3,5/4)-trihydroxycyclohexane-1,2-dione acylhydrolase (Decyclizing) {ECO:0000313|EMBL:KUJ36671.1};
GN   ORFNames=ADL25_31555 {ECO:0000313|EMBL:KUJ36671.1};
OS   Streptomyces sp. NRRL F-5122.
OC   Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC   Streptomycetaceae; Streptomyces.
OX   NCBI_TaxID=1609098 {ECO:0000313|EMBL:KUJ36671.1, ECO:0000313|Proteomes:UP000054048};
RN   [1] {ECO:0000313|Proteomes:UP000054048}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NRRL F-5122 {ECO:0000313|Proteomes:UP000054048};
RA   Ju K.-S., Doroghazi J.R., Metcalf W.W.;
RL   Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the TPP enzyme family.
CC       {ECO:0000256|ARBA:ARBA00007812, ECO:0000256|RuleBase:RU362132}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KUJ36671.1}.
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DR   EMBL; LMWH01000252; KUJ36671.1; -; Genomic_DNA.
DR   RefSeq; WP_059131303.1; NZ_LMWH01000252.1.
DR   AlphaFoldDB; A0A0X3S4G3; -.
DR   OrthoDB; 3194735at2; -.
DR   Proteomes; UP000054048; Unassembled WGS sequence.
DR   GO; GO:0016823; F:hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances; IEA:InterPro.
DR   GO; GO:0000287; F:magnesium ion binding; IEA:InterPro.
DR   GO; GO:0030976; F:thiamine pyrophosphate binding; IEA:InterPro.
DR   GO; GO:0019310; P:inositol catabolic process; IEA:InterPro.
DR   CDD; cd07035; TPP_PYR_POX_like; 1.
DR   Gene3D; 3.40.50.970; -; 2.
DR   Gene3D; 3.40.50.1220; TPP-binding domain; 1.
DR   InterPro; IPR029035; DHS-like_NAD/FAD-binding_dom.
DR   InterPro; IPR030817; Myo_inos_IolD.
DR   InterPro; IPR029061; THDP-binding.
DR   InterPro; IPR012000; Thiamin_PyroP_enz_cen_dom.
DR   InterPro; IPR012001; Thiamin_PyroP_enz_TPP-bd_dom.
DR   InterPro; IPR045229; TPP_enz.
DR   InterPro; IPR011766; TPP_enzyme_TPP-bd.
DR   NCBIfam; TIGR04377; myo_inos_iolD; 1.
DR   PANTHER; PTHR18968:SF9; 3D-(3,5/4)-TRIHYDROXYCYCLOHEXANE-1,2-DIONE HYDROLASE; 1.
DR   PANTHER; PTHR18968; THIAMINE PYROPHOSPHATE ENZYMES; 1.
DR   Pfam; PF02775; TPP_enzyme_C; 1.
DR   Pfam; PF00205; TPP_enzyme_M; 1.
DR   Pfam; PF02776; TPP_enzyme_N; 1.
DR   SUPFAM; SSF52467; DHS-like NAD/FAD-binding domain; 1.
DR   SUPFAM; SSF52518; Thiamin diphosphate-binding fold (THDP-binding); 2.
PE   3: Inferred from homology;
KW   Hydrolase {ECO:0000313|EMBL:KUJ36671.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000054048};
KW   Thiamine pyrophosphate {ECO:0000256|RuleBase:RU362132}.
FT   DOMAIN          8..131
FT                   /note="Thiamine pyrophosphate enzyme N-terminal TPP-
FT                   binding"
FT                   /evidence="ECO:0000259|Pfam:PF02776"
FT   DOMAIN          221..354
FT                   /note="Thiamine pyrophosphate enzyme central"
FT                   /evidence="ECO:0000259|Pfam:PF00205"
FT   DOMAIN          420..577
FT                   /note="Thiamine pyrophosphate enzyme TPP-binding"
FT                   /evidence="ECO:0000259|Pfam:PF02775"
FT   REGION          607..627
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   627 AA;  67548 MW;  0BF8DA2919A5C5B2 CRC64;
     MTSTTRLTVA QALVRFLAAQ YTERDGVRRR LIGATWGIFG HGNVAGVGQA LLEYGGVMPY
     HQGRNEQAMV HAAVGWARQC DRLSTHAVTT SIGPGATNLV TGAALATVNR LPVLLLPGDV
     FATRPADPVL QQLEVPHAGD TSVNDCLRPV SKYFDRITRP EALIPAVLQA MRVLTDPVET
     GAVTLALPQD VQAEAHDWPQ DLFAERTWTV RRPGPDPVEL AEAVQAIRAA RRPLVVAGGG
     VHHSRAEDAL AEFAGTTGIP VASTQAGKGS LRWDHPQDVG GIGHTGTATA DELARTADLV
     IGVGTRYTDF TTASGTLFIR DGVRFLNLNI APFDGHKLSG LPLVADARSG LEELTEALEM
     HGHRVEPAYV VEYTEDKERW EQRVDACFDA DEPDIRPTQT QVIGALDALV DESDVIVNAA
     GSLPGDLHRL WRSRSRDQYH VEYGYSCMGY EIPAAIGVKM AAPDRAVWAL VGDGTYLMMP
     TEIVTAVQEG IAIKVLIVQN HGYASIGGLS ESVGGERFGT AYRYRSEDGA YTGAPLPVDL
     AANAASLGMR VLRAKTVRDL RRALAEARAA DTPTCVYVET QTADTVSGAP GTQAWWDVPV
     AETATRSSAV KAREEYDRHV STRRRHL
//
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