GenomeNet

Database: UniProt
Entry: A0A0X3S5S0_9ACTN
LinkDB: A0A0X3S5S0_9ACTN
Original site: A0A0X3S5S0_9ACTN 
ID   A0A0X3S5S0_9ACTN        Unreviewed;       580 AA.
AC   A0A0X3S5S0;
DT   13-APR-2016, integrated into UniProtKB/TrEMBL.
DT   13-APR-2016, sequence version 1.
DT   24-JAN-2024, entry version 15.
DE   SubName: Full=Pyruvate dehydrogenase {ECO:0000313|EMBL:KUJ39004.1};
GN   ORFNames=ADL25_22515 {ECO:0000313|EMBL:KUJ39004.1};
OS   Streptomyces sp. NRRL F-5122.
OC   Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC   Streptomycetaceae; Streptomyces.
OX   NCBI_TaxID=1609098 {ECO:0000313|EMBL:KUJ39004.1, ECO:0000313|Proteomes:UP000054048};
RN   [1] {ECO:0000313|Proteomes:UP000054048}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NRRL F-5122 {ECO:0000313|Proteomes:UP000054048};
RA   Ju K.-S., Doroghazi J.R., Metcalf W.W.;
RL   Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the TPP enzyme family.
CC       {ECO:0000256|ARBA:ARBA00007812, ECO:0000256|RuleBase:RU362132}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KUJ39004.1}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; LMWH01000228; KUJ39004.1; -; Genomic_DNA.
DR   RefSeq; WP_059129561.1; NZ_LMWH01000228.1.
DR   AlphaFoldDB; A0A0X3S5S0; -.
DR   OrthoDB; 4959782at2; -.
DR   Proteomes; UP000054048; Unassembled WGS sequence.
DR   GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR   GO; GO:0000287; F:magnesium ion binding; IEA:InterPro.
DR   GO; GO:0030976; F:thiamine pyrophosphate binding; IEA:InterPro.
DR   CDD; cd02014; TPP_POX; 1.
DR   CDD; cd07039; TPP_PYR_POX; 1.
DR   Gene3D; 3.40.50.970; -; 2.
DR   Gene3D; 3.40.50.1220; TPP-binding domain; 1.
DR   InterPro; IPR029035; DHS-like_NAD/FAD-binding_dom.
DR   InterPro; IPR047211; POXB-like.
DR   InterPro; IPR029061; THDP-binding.
DR   InterPro; IPR012000; Thiamin_PyroP_enz_cen_dom.
DR   InterPro; IPR012001; Thiamin_PyroP_enz_TPP-bd_dom.
DR   InterPro; IPR011766; TPP_enzyme_TPP-bd.
DR   InterPro; IPR047212; TPP_POXB-like.
DR   InterPro; IPR047210; TPP_PYR_POXB-like.
DR   PANTHER; PTHR42981; PYRUVATE DEHYDROGENASE [UBIQUINONE]; 1.
DR   PANTHER; PTHR42981:SF2; PYRUVATE DEHYDROGENASE [UBIQUINONE]; 1.
DR   Pfam; PF02775; TPP_enzyme_C; 1.
DR   Pfam; PF00205; TPP_enzyme_M; 1.
DR   Pfam; PF02776; TPP_enzyme_N; 1.
DR   SUPFAM; SSF52467; DHS-like NAD/FAD-binding domain; 1.
DR   SUPFAM; SSF52518; Thiamin diphosphate-binding fold (THDP-binding); 2.
PE   3: Inferred from homology;
KW   Pyruvate {ECO:0000313|EMBL:KUJ39004.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000054048};
KW   Thiamine pyrophosphate {ECO:0000256|RuleBase:RU362132}.
FT   DOMAIN          5..116
FT                   /note="Thiamine pyrophosphate enzyme N-terminal TPP-
FT                   binding"
FT                   /evidence="ECO:0000259|Pfam:PF02776"
FT   DOMAIN          192..320
FT                   /note="Thiamine pyrophosphate enzyme central"
FT                   /evidence="ECO:0000259|Pfam:PF00205"
FT   DOMAIN          383..529
FT                   /note="Thiamine pyrophosphate enzyme TPP-binding"
FT                   /evidence="ECO:0000259|Pfam:PF02775"
SQ   SEQUENCE   580 AA;  62656 MW;  482E05144812D5F4 CRC64;
     MAKQNVADQF VDILARAGVK RLYGVVGDSL NPIVDAVRRN AALDWVHVRH EETAAFAAGA
     EAQITGRLAA CAGSCGPGNL HLVNGLYDAH RSMAPVLALA SHIPSSEIGL GYFQETHPDR
     LFQECSHYCE LISNPKQMPR LLQTAIQNAI GRSGVSVVAL PGDIADQPAP DKPVQTALVT
     ARPTVRPSDA EIDKLVAMID EAERVTLFCG SGTAGAHAEV MELAGKIKSP VGHALRGKEW
     IQYDNPFDVG MSGLLGYGAA YEATHECDLL ILLGTDFPYN AFLPDDVTIA QVDVRPENLG
     RRSKLDLAVW GDVKETLRCL TPRLRPKQNR RFLDKMLKKH ADALEGVVKA YTRKVDKHVP
     IHPEYVASVL DELAHPEAVF TVDTGMCNVW AARYISPNGR RRIIGSFSHG SMANALPMAI
     GAQFTDRNRQ VVSISGDGGF SMLMGDFLTL VQLDLPVKVV LFNNSSLGMV ELEMMVAGLP
     SYGTANQNPD FAAVARACGA YGIRVEKPKQ LPGALKDAFR HKGPALVDIV TDPNALSIPP
     RISREMVTGF ALSASKVVLD GGVGRMVQMA RSNLRNVPRP
//
DBGET integrated database retrieval system