ID A0A0X3SDL0_9ACTN Unreviewed; 485 AA.
AC A0A0X3SDL0;
DT 13-APR-2016, integrated into UniProtKB/TrEMBL.
DT 13-APR-2016, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE SubName: Full=MFS transporter {ECO:0000313|EMBL:KUJ38995.1};
GN ORFNames=ADL25_22460 {ECO:0000313|EMBL:KUJ38995.1};
OS Streptomyces sp. NRRL F-5122.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1609098 {ECO:0000313|EMBL:KUJ38995.1, ECO:0000313|Proteomes:UP000054048};
RN [1] {ECO:0000313|Proteomes:UP000054048}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NRRL F-5122 {ECO:0000313|Proteomes:UP000054048};
RA Ju K.-S., Doroghazi J.R., Metcalf W.W.;
RL Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC
CC 2.A.40) family. Azg-like subfamily. {ECO:0000256|ARBA:ARBA00005697}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KUJ38995.1}.
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DR EMBL; LMWH01000228; KUJ38995.1; -; Genomic_DNA.
DR RefSeq; WP_059129552.1; NZ_LMWH01000228.1.
DR AlphaFoldDB; A0A0X3SDL0; -.
DR OrthoDB; 9808458at2; -.
DR Proteomes; UP000054048; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015205; F:nucleobase transmembrane transporter activity; IEA:InterPro.
DR GO; GO:1904823; P:purine nucleobase transmembrane transport; IEA:UniProt.
DR InterPro; IPR045018; Azg-like.
DR InterPro; IPR006043; NCS2.
DR PANTHER; PTHR43337; XANTHINE/URACIL PERMEASE C887.17-RELATED; 1.
DR PANTHER; PTHR43337:SF1; XANTHINE_URACIL PERMEASE C887.17-RELATED; 1.
DR Pfam; PF00860; Xan_ur_permease; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000054048};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 45..66
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 128..148
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 160..179
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 199..217
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 224..246
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 284..309
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 329..351
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 363..384
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 391..407
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 419..446
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 458..475
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 485 AA; 49863 MW; 3762640CC4134CA2 CRC64;
MTQQSVDSRT TAEDAGAGTR VPAGRSWLDR YFHISRRGST LAREVRGGVT TFMAMAYILL
LNPLILSGKD AAGDTLGRQA LITATAFAAA FTTLLMGFAG KAPLALAAGL SVSGVLSSQV
APQMTWPQAM GMCVVYGAVI MLLVVTGLRE MVMSAIPPAL KYGITMGIGL FIALIGFYKS
GFVHQGKATP VTLGPAGQLT GWPVLLFAGT LLLIFMLQAR NVPGAILIGI VSGTVVASGL
NALGVVDANS WASGAPELHG SAMSMPDFSL LGHVDFGGWG DVGAMTVGLI VFTLVLAGFF
DAMATIIGVG TEAGLADDKG RMPGLSKALF IDGAGGVIGG VAGGSGQTVF IESATGVGEG
ARTGLASVVI GLFFAACLFF TPLTAIVPQE VASAALVVIG AMMLMNARHV DWSDRATAIP
VFLTVVLMPF TYTITTGVAA GVVSYVAIKA AQGKAREIGA FMWGLTAVFL IYFALNPIES
WLGVH
//
