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Database: UniProt
Entry: A0A0X3SWQ1_9ACTN
LinkDB: A0A0X3SWQ1_9ACTN
Original site: A0A0X3SWQ1_9ACTN 
ID   A0A0X3SWQ1_9ACTN        Unreviewed;       603 AA.
AC   A0A0X3SWQ1;
DT   13-APR-2016, integrated into UniProtKB/TrEMBL.
DT   13-APR-2016, sequence version 1.
DT   05-JUL-2017, entry version 12.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|HAMAP-Rule:MF_00377, ECO:0000256|RuleBase:RU000577};
GN   Name=dnaA {ECO:0000256|HAMAP-Rule:MF_00377,
GN   ECO:0000313|EMBL:KUJ67934.1};
GN   ORFNames=ACZ90_23750 {ECO:0000313|EMBL:KUJ67934.1};
OS   Streptomyces albus subsp. albus.
OC   Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
OC   Streptomyces.
OX   NCBI_TaxID=67257 {ECO:0000313|EMBL:KUJ67934.1, ECO:0000313|Proteomes:UP000054175};
RN   [1] {ECO:0000313|EMBL:KUJ67934.1, ECO:0000313|Proteomes:UP000054175}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NRRL B-2513 {ECO:0000313|EMBL:KUJ67934.1,
RC   ECO:0000313|Proteomes:UP000054175};
RA   Millard Andrew;
RL   Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731907}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|SAAS:SAAS00756131}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00377, ECO:0000256|RuleBase:RU004227,
CC       ECO:0000256|SAAS:SAAS00555179}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:KUJ67934.1}.
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DR   EMBL; LMWG01001670; KUJ67934.1; -; Genomic_DNA.
DR   EnsemblBacteria; KUJ67934; KUJ67934; ACZ90_23750.
DR   Proteomes; UP000054175; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-HAMAP.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-HAMAP.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-HAMAP.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-HAMAP.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF12; PTHR30050:SF12; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731922};
KW   Complete proteome {ECO:0000313|Proteomes:UP000054175};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|SAAS:SAAS00756112};
KW   DNA replication {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU004227, ECO:0000256|SAAS:SAAS00731887};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00756124};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731897};
KW   Reference proteome {ECO:0000313|Proteomes:UP000054175}.
FT   DOMAIN      296    424       AAA. {ECO:0000259|SMART:SM00382}.
FT   DOMAIN      510    579       Bac_DnaA_C. {ECO:0000259|SMART:SM00760}.
FT   NP_BIND     304    311       ATP. {ECO:0000256|HAMAP-Rule:MF_00377}.
SQ   SEQUENCE   603 AA;  65627 MW;  8BF00D30E7F19CE9 CRC64;
     MLEQLLGEGR GHGVEAKDEH WIKRCQPLAL VADTALLAVP NEFAKGVLEG RLAPLISDTL
     SRECGRPIRI AITVDDSAGE PPAPPQRPQP PQSRYEEPQR EAYPGREQRE GYEREGGYEG
     GYGRASDDLP TARPAYPDYP QARPEPGAWP RSQEDYAWQQ PRLGGFPESG DPYTSQRGQR
     PYEQRGRELP DQGERPRGGP GAGPGRPGAG HPGGGPASGA PGAPGGTAGP GGPGGPSSPG
     GTPGGPLTAQ PAPASGPGEP TARLNPKYLF DTFVIGASNR FAHAAAVAVA EAPAKAYNPL
     FIYGESGLGK THLLHAIGHY ARSLYPGTRV RYVSSEEFTN EFINSIRDGK ADAFRKRYRD
     MDILLVDDIQ FLASKESTQE EFFHTFNTLH NANKQIVLSS DRPPKQLVTL EDRLRNRFEW
     GLITDVQPPE LETRIAILRK KAVQEQLNAP PEVLEFIASR ISRNIRELEG ALIRVTAFAS
     LNRQPVDLGL TEIVLKDLIP GGEDTAPEIT ATAIMAATAD YFGHTVEDLC GASRSRVLVT
     ARQIAMYLCR ELTDLSLPKI GAQFGGRDHT TVMHADRKIR ALMAERRSIY NQVTELTNRI
     KNG
//
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