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Database: UniProt
Entry: A0A0X3TB81_9GAMM
LinkDB: A0A0X3TB81_9GAMM
Original site: A0A0X3TB81_9GAMM 
ID   A0A0X3TB81_9GAMM        Unreviewed;       480 AA.
AC   A0A0X3TB81;
DT   13-APR-2016, integrated into UniProtKB/TrEMBL.
DT   13-APR-2016, sequence version 1.
DT   27-SEP-2017, entry version 13.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|HAMAP-Rule:MF_00377, ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00724181};
GN   Name=dnaA {ECO:0000256|HAMAP-Rule:MF_00377};
GN   ORFNames=AVO41_00590 {ECO:0000313|EMBL:KUJ73032.1};
OS   Thiomicrospira sp. WB1.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Thiotrichales;
OC   Piscirickettsiaceae; Thiomicrospira.
OX   NCBI_TaxID=1685380 {ECO:0000313|EMBL:KUJ73032.1, ECO:0000313|Proteomes:UP000053531};
RN   [1] {ECO:0000313|EMBL:KUJ73032.1, ECO:0000313|Proteomes:UP000053531}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=WB1 {ECO:0000313|EMBL:KUJ73032.1,
RC   ECO:0000313|Proteomes:UP000053531};
RA   Shamseldin A., Moawad H., Abd El-Rahim W.M., Sadowsky M.J.;
RL   Submitted (DEC-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00724167}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|SAAS:SAAS00756131}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00377, ECO:0000256|RuleBase:RU004227,
CC       ECO:0000256|SAAS:SAAS00555179}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:KUJ73032.1}.
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DR   EMBL; LQBN01000001; KUJ73032.1; -; Genomic_DNA.
DR   RefSeq; WP_068583153.1; NZ_LQBN01000001.1.
DR   EnsemblBacteria; KUJ73032; KUJ73032; AVO41_00590.
DR   Proteomes; UP000053531; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-UniRule.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-UniRule.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR024633; DnaA_N_dom.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF12; PTHR30050:SF12; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   Pfam; PF11638; DnaA_N; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731922};
KW   Complete proteome {ECO:0000313|Proteomes:UP000053531};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|SAAS:SAAS00756112};
KW   DNA replication {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU004227, ECO:0000256|SAAS:SAAS00731887};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00756124};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731897};
KW   Reference proteome {ECO:0000313|Proteomes:UP000053531}.
FT   DOMAIN      177    307       AAA. {ECO:0000259|SMART:SM00382}.
FT   DOMAIN      388    457       Bac_DnaA_C. {ECO:0000259|SMART:SM00760}.
FT   NP_BIND     185    192       ATP. {ECO:0000256|HAMAP-Rule:MF_00377}.
SQ   SEQUENCE   480 AA;  54156 MW;  F7AAA44CA642AE76 CRC64;
     MSTVLWPQAL KHLESGLSNV QFLTWIRPLE AIESDQTLRL IAPSGFIYDW VNDKLIDQIE
     QAVQQVAPAN TPRVSLEIGD YAIDRIEEVD PTRPHAQQAT GPLADFSHRP ADSDTSATSS
     QQATYQERSN PDEASQEPSG IKHNLNTHFT FETFVEGKAN QLAAAAAHQV ADNPGGGYNP
     FFIYGGSGLG KTHLMHAIGN LLMKRNPQAR VVYLHSERFV ADMVNALRHK KIESFKRFYR
     SLDALLIDDI QFFANKEQSQ EEFFHTFNTL LEGNKQVILT SDRFPKEVEG LEDRLKSRFG
     WGLTVAVEPP EFEMRVAILL KKAHEFGFLL SDDVAFFIAK RLRGNVRDLE GALKRVGAFA
     QFTQQAITVS LAKEALKDLL ALQQKMVTLE NIQKTVADYY KIRVADILSK RRTRNIARPR
     QMAMAIAKEL TQHSLPEIGD AFGGRDHTTV LHAIKKIKEL TETDHQLGED WQTLIRIITN
//
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