ID A0A0X3U5C9_9GAMM Unreviewed; 552 AA.
AC A0A0X3U5C9;
DT 13-APR-2016, integrated into UniProtKB/TrEMBL.
DT 13-APR-2016, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE RecName: Full=Membrane protein insertase YidC {ECO:0000256|ARBA:ARBA00015325, ECO:0000256|HAMAP-Rule:MF_01810};
DE AltName: Full=Foldase YidC {ECO:0000256|ARBA:ARBA00033342, ECO:0000256|HAMAP-Rule:MF_01810};
DE AltName: Full=Membrane integrase YidC {ECO:0000256|ARBA:ARBA00033245, ECO:0000256|HAMAP-Rule:MF_01810};
DE AltName: Full=Membrane protein YidC {ECO:0000256|HAMAP-Rule:MF_01810};
GN Name=yidC {ECO:0000256|HAMAP-Rule:MF_01810};
GN ORFNames=AVO43_11210 {ECO:0000313|EMBL:KUJ83099.1};
OS Microbulbifer sp. ZGT114.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Cellvibrionales;
OC Microbulbiferaceae; Microbulbifer.
OX NCBI_TaxID=1685377 {ECO:0000313|EMBL:KUJ83099.1, ECO:0000313|Proteomes:UP000054457};
RN [1] {ECO:0000313|EMBL:KUJ83099.1, ECO:0000313|Proteomes:UP000054457}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ZGT114 {ECO:0000313|EMBL:KUJ83099.1,
RC ECO:0000313|Proteomes:UP000054457};
RA Shamseldin A., Moawad H., Abd El-Rahim W.M., Sadowsky M.J.;
RL Submitted (DEC-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Required for the insertion and/or proper folding and/or
CC complex formation of integral membrane proteins into the membrane.
CC Involved in integration of membrane proteins that insert both
CC dependently and independently of the Sec translocase complex, as well
CC as at least some lipoproteins. Aids folding of multispanning membrane
CC proteins. {ECO:0000256|HAMAP-Rule:MF_01810}.
CC -!- SUBUNIT: Interacts with the Sec translocase complex via SecD.
CC Specifically interacts with transmembrane segments of nascent integral
CC membrane proteins during membrane integration. {ECO:0000256|HAMAP-
CC Rule:MF_01810}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|HAMAP-Rule:MF_01810};
CC Multi-pass membrane protein {ECO:0000256|HAMAP-Rule:MF_01810}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.
CC {ECO:0000256|ARBA:ARBA00010527, ECO:0000256|HAMAP-Rule:MF_01810}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KUJ83099.1}.
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DR EMBL; LQBR01000003; KUJ83099.1; -; Genomic_DNA.
DR RefSeq; WP_067084835.1; NZ_LQBR01000003.1.
DR AlphaFoldDB; A0A0X3U5C9; -.
DR STRING; 1685377.AVO43_11210; -.
DR Proteomes; UP000054457; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0032977; F:membrane insertase activity; IEA:InterPro.
DR GO; GO:0051205; P:protein insertion into membrane; IEA:UniProt.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR CDD; cd20070; 5TM_YidC_Alb3; 1.
DR CDD; cd19961; EcYidC-like_peri; 1.
DR Gene3D; 2.70.98.90; -; 1.
DR HAMAP; MF_01810; YidC_type1; 1.
DR InterPro; IPR019998; Membr_insert_YidC.
DR InterPro; IPR028053; Membr_insert_YidC_N.
DR InterPro; IPR001708; YidC/ALB3/OXA1/COX18.
DR InterPro; IPR028055; YidC/Oxa/ALB_C.
DR InterPro; IPR047196; YidC_ALB_C.
DR InterPro; IPR038221; YidC_periplasmic_sf.
DR NCBIfam; TIGR03593; yidC_nterm; 1.
DR NCBIfam; TIGR03592; yidC_oxa1_cterm; 1.
DR PANTHER; PTHR12428:SF65; INNER MEMBRANE PROTEIN ALBINO3, CHLOROPLASTIC; 1.
DR PANTHER; PTHR12428; OXA1; 1.
DR Pfam; PF02096; 60KD_IMP; 1.
DR Pfam; PF14849; YidC_periplas; 1.
DR PRINTS; PR00701; 60KDINNERMP.
DR PRINTS; PR01900; YIDCPROTEIN.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475, ECO:0000256|HAMAP-
KW Rule:MF_01810};
KW Chaperone {ECO:0000256|ARBA:ARBA00023186, ECO:0000256|HAMAP-Rule:MF_01810};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|HAMAP-Rule:MF_01810};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927, ECO:0000256|HAMAP-
KW Rule:MF_01810}; Reference proteome {ECO:0000313|Proteomes:UP000054457};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|HAMAP-
KW Rule:MF_01810};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989, ECO:0000256|HAMAP-
KW Rule:MF_01810};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|HAMAP-Rule:MF_01810}.
FT TRANSMEM 6..23
FT /note="Helical"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01810"
FT TRANSMEM 366..390
FT /note="Helical"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01810"
FT TRANSMEM 432..453
FT /note="Helical"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01810"
FT TRANSMEM 512..531
FT /note="Helical"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01810"
FT DOMAIN 80..355
FT /note="Membrane insertase YidC N-terminal"
FT /evidence="ECO:0000259|Pfam:PF14849"
FT DOMAIN 367..545
FT /note="Membrane insertase YidC/Oxa/ALB C-terminal"
FT /evidence="ECO:0000259|Pfam:PF02096"
SQ SEQUENCE 552 AA; 63024 MW; 905DEF4DC2F465C2 CRC64;
MDWQRYTLLG GIAAVILALI FQWNEFKEER APAIDRETVV RTDIPDTVTT PEPQAATEDV
PTLQSETVPQ AAGPQERQLI SVETDVFSLL IDPRGGDIVK VALRDYYEQL NTPDRPFILL
NQTRDHTYIA QSGLIGRNGT DSAAGRPLFS VAETEYALKA GSDSLVVDLT LQQDGANITK
RFTFKRGDYL VDVQYLVDNT SEQPWRAAMF GQIKRDSAEP PVDVGIGMSP FLGAALHTSE
ENYFKQDFEE IAEEPTRESI VGGWVAMVQH YFISAWVPPQ DVRNNFELRQ LSSGLFRMGF
TAPQVEIPAN SQGELSAAFY AGPKDVFRLE EISPYLDLTV DYGWLWWLAK PMFWVLNFIY
ENIVANWGWA IVLLTVFIKA LLYPLSAAGL KSMARMRKFA PQMKKLQEQY KDNRQKLAEE
TMKLYRREKI NPMGGCLPIL LQMPVFIGLY WMLMETVELR HAPWILWIHD LSAKDPYFIL
PVIMGLTMWL MQKLQPQPTD PTQARIMQLM PVMMTFFFLW FPAGLVLYWI ANNVLSIAQT
WYINKQVESA SS
//
