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Database: UniProt
Entry: A0A0X3UXW5_9ACTN
LinkDB: A0A0X3UXW5_9ACTN
Original site: A0A0X3UXW5_9ACTN 
ID   A0A0X3UXW5_9ACTN        Unreviewed;       486 AA.
AC   A0A0X3UXW5;
DT   13-APR-2016, integrated into UniProtKB/TrEMBL.
DT   13-APR-2016, sequence version 1.
DT   25-OCT-2017, entry version 9.
DE   SubName: Full=Malate dehydrogenase {ECO:0000313|EMBL:KUL35816.1};
GN   ORFNames=ADL15_13710 {ECO:0000313|EMBL:KUL35816.1};
OS   Actinoplanes awajinensis subsp. mycoplanecinus.
OC   Bacteria; Actinobacteria; Micromonosporales; Micromonosporaceae;
OC   Actinoplanes.
OX   NCBI_TaxID=135947 {ECO:0000313|EMBL:KUL35816.1, ECO:0000313|Proteomes:UP000053244};
RN   [1] {ECO:0000313|EMBL:KUL35816.1, ECO:0000313|Proteomes:UP000053244}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NRRL B-16712 {ECO:0000313|EMBL:KUL35816.1,
RC   ECO:0000313|Proteomes:UP000053244};
RA   Millard Andrew;
RL   Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC         Evidence={ECO:0000256|PIRSR:PIRSR000106-3};
CC       Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC         Evidence={ECO:0000256|PIRSR:PIRSR000106-3};
CC       Note=Divalent metal cations. Prefers magnesium or manganese.
CC       {ECO:0000256|PIRSR:PIRSR000106-3};
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:KUL35816.1}.
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DR   EMBL; LLZH01000097; KUL35816.1; -; Genomic_DNA.
DR   RefSeq; WP_067689381.1; NZ_LLZH01000097.1.
DR   EnsemblBacteria; KUL35816; KUL35816; ADL15_13710.
DR   Proteomes; UP000053244; Unassembled WGS sequence.
DR   GO; GO:0004471; F:malate dehydrogenase (decarboxylating) (NAD+) activity; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR   Gene3D; 3.40.50.10380; -; 1.
DR   InterPro; IPR012301; Malic_N_dom.
DR   InterPro; IPR037062; Malic_N_dom_sf.
DR   InterPro; IPR012302; Malic_NAD-bd.
DR   InterPro; IPR001891; Malic_OxRdtase.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   Pfam; PF00390; malic; 1.
DR   Pfam; PF03949; Malic_M; 1.
DR   PIRSF; PIRSF000106; ME; 1.
DR   SMART; SM01274; malic; 1.
DR   SMART; SM00919; Malic_M; 1.
DR   SUPFAM; SSF51735; SSF51735; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000053244};
KW   Metal-binding {ECO:0000256|PIRSR:PIRSR000106-3};
KW   Reference proteome {ECO:0000313|Proteomes:UP000053244}.
FT   DOMAIN       95    228       malic. {ECO:0000259|SMART:SM01274}.
FT   DOMAIN      240    462       Malic_M. {ECO:0000259|SMART:SM00919}.
FT   ACT_SITE    116    116       Proton donor. {ECO:0000256|PIRSR:
FT                                PIRSR000106-1}.
FT   ACT_SITE    171    171       Proton acceptor. {ECO:0000256|PIRSR:
FT                                PIRSR000106-1}.
FT   METAL       213    213       Divalent metal cation.
FT                                {ECO:0000256|PIRSR:PIRSR000106-3}.
FT   METAL       214    214       Divalent metal cation.
FT                                {ECO:0000256|PIRSR:PIRSR000106-3}.
FT   METAL       239    239       Divalent metal cation.
FT                                {ECO:0000256|PIRSR:PIRSR000106-3}.
SQ   SEQUENCE   486 AA;  50979 MW;  3B4F96F27D163B37 CRC64;
     MVTTRLPSAG FSITIRIAVT ADASSIGRLT TCVGEAGAIV TALDVVDSDP TRVLVDLTCD
     TADSGHADQV VKQLEDQDGV DVRKVSDRTF LLHLGGKIEV NSKVALRNRD ELSRAYTPGV
     ARVCMAIAEN PADARRLTIK RNTVAVVSDG SAVLGLGNIG PAAAMPVMEG KAALFKRFGG
     VDAWPVVLDT QDTDEIVRIV KAIAPAYGGI NLEDIAAPRC FEIEARLREE LDIPVFHDDQ
     HGTAICVLAA LTNALRVVGK RMEDVRVVVS GAGAAGTAIM KLLMRQGVGD IIAYDRNGAL
     HRGMAGLNES MQWLADNTNE ANYSGDLPGA IVGADVFIGV SAPNLLTGDD IAKMAGKSIV
     FAMANPDPEV DPREARKHAA IVATGRSDQP NQINNVLAFP GVFRGMLDAA AEEFTEEMAL
     AAARAIADVV GEDKLNPTVI VPSVFDPRVT PAVAAAIRAV VRGGPAPSNP AAAPESDLDK
     APETTF
//
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