ID A0A0X3UXW7_9ACTN Unreviewed; 536 AA.
AC A0A0X3UXW7;
DT 13-APR-2016, integrated into UniProtKB/TrEMBL.
DT 13-APR-2016, sequence version 1.
DT 24-JAN-2024, entry version 27.
DE SubName: Full=Choline dehydrogenase {ECO:0000313|EMBL:KUL37340.1};
GN ORFNames=ADL22_21980 {ECO:0000313|EMBL:KUL37340.1};
OS Streptomyces sp. NRRL F-4489.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1609095 {ECO:0000313|EMBL:KUL37340.1, ECO:0000313|Proteomes:UP000053256};
RN [1] {ECO:0000313|EMBL:KUL37340.1, ECO:0000313|Proteomes:UP000053256}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NRRL F-4489 {ECO:0000313|EMBL:KUL37340.1,
RC ECO:0000313|Proteomes:UP000053256};
RA Gilbert D.G.;
RL Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=FAD; Xref=ChEBI:CHEBI:57692;
CC Evidence={ECO:0000256|ARBA:ARBA00001974,
CC ECO:0000256|PIRSR:PIRSR000137-2};
CC -!- SIMILARITY: Belongs to the GMC oxidoreductase family.
CC {ECO:0000256|ARBA:ARBA00010790}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KUL37340.1}.
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DR EMBL; LLZI01000237; KUL37340.1; -; Genomic_DNA.
DR RefSeq; WP_066982374.1; NZ_LLZI01000237.1.
DR AlphaFoldDB; A0A0X3UXW7; -.
DR STRING; 1609095.ADL22_21980; -.
DR OrthoDB; 9785276at2; -.
DR Proteomes; UP000053256; Unassembled WGS sequence.
DR GO; GO:0050660; F:flavin adenine dinucleotide binding; IEA:InterPro.
DR GO; GO:0016614; F:oxidoreductase activity, acting on CH-OH group of donors; IEA:InterPro.
DR Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 1.
DR Gene3D; 3.30.560.10; Glucose Oxidase, domain 3; 1.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR InterPro; IPR012132; GMC_OxRdtase.
DR InterPro; IPR000172; GMC_OxRdtase_N.
DR InterPro; IPR007867; GMC_OxRtase_C.
DR PANTHER; PTHR11552:SF147; CHOLINE DEHYDROGENASE, MITOCHONDRIAL; 1.
DR PANTHER; PTHR11552; GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE; 1.
DR Pfam; PF05199; GMC_oxred_C; 1.
DR Pfam; PF00732; GMC_oxred_N; 1.
DR PIRSF; PIRSF000137; Alcohol_oxidase; 1.
DR SUPFAM; SSF54373; FAD-linked reductases, C-terminal domain; 1.
DR SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
DR PROSITE; PS00624; GMC_OXRED_2; 1.
PE 3: Inferred from homology;
KW FAD {ECO:0000256|ARBA:ARBA00022827, ECO:0000256|PIRSR:PIRSR000137-2};
KW Flavoprotein {ECO:0000256|ARBA:ARBA00022630};
KW Reference proteome {ECO:0000313|Proteomes:UP000053256}.
FT DOMAIN 253..267
FT /note="Glucose-methanol-choline oxidoreductase N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS00624"
FT BINDING 218
FT /ligand="FAD"
FT /ligand_id="ChEBI:CHEBI:57692"
FT /evidence="ECO:0000256|PIRSR:PIRSR000137-2"
SQ SEQUENCE 536 AA; 58576 MW; 22B518D3D1F631A3 CRC64;
MRTHDYIIVG SGAAGSVLAG RLTENPAISV LLLESGRERR SPLLTIPAAE TVLMGNPAYD
WCFRTDADPT LEGRSLAIPR GRLLGGSNAI NGMIFVRGQR EDYDDWARLG NPGWSWDGVL
PYFKSMERAP GIGGETRGRT GPIAVGPPRD RDALCDTFLT AAGKAGYPEN RDYNSGDQEG
FGYYQVNHED GRRSSAGRTY LKDARRRPNL TLVTDAHVGT LRFDGTRCTG VTFRHNGTEH
RADCRREVIV SAGAIQSPQL LELSGIGSAD VLTGAGVPVV HHLPGVGENF QDHYAARLRW
RVRQPITFNE RSRGLGLLRE VVRYARTRHG LLSLPIALGF GFVRTSDAEE RPDIQFHFAP
ASYGEGASRR LDTAPGMTLG VYPLRPESRG SIHIRSRDPL TAPAIRPRFL DAEGDRTRLV
AGMRLARRIV EQPAFDPYRA AELVPGADVR TDDELLAYAR AHGDTSYHPV GTCRMGDDPM
AVVDARLRVR GVHGLRVIDA SVMPVIVSGN TNAASMMIGE KGAAMVLEDH RNSDRA
//
