ID   A0A0X3VFL8_9ACTN        Unreviewed;       423 AA.
AC   A0A0X3VFL8;
DT   13-APR-2016, integrated into UniProtKB/TrEMBL.
DT   13-APR-2016, sequence version 1.
DT   27-MAR-2024, entry version 32.
DE   SubName: Full=Alpha-1-antitrypsin {ECO:0000313|EMBL:KUL43478.1};
GN   ORFNames=ADL12_07760 {ECO:0000313|EMBL:KUL43478.1};
OS   Streptomyces regalis.
OC   Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC   Streptomycetaceae; Streptomyces.
OX   NCBI_TaxID=68262 {ECO:0000313|EMBL:KUL43478.1, ECO:0000313|Proteomes:UP000053923};
RN   [1] {ECO:0000313|Proteomes:UP000053923}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NRRL 3151 {ECO:0000313|Proteomes:UP000053923};
RA   Ju K.-S., Doroghazi J.R., Metcalf W.W.;
RL   Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KUL43478.1}.
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DR   EMBL; LLZG01000036; KUL43478.1; -; Genomic_DNA.
DR   RefSeq; WP_062699936.1; NZ_LLZG01000036.1.
DR   AlphaFoldDB; A0A0X3VFL8; -.
DR   OrthoDB; 4318225at2; -.
DR   Proteomes; UP000053923; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR   InterPro; IPR002035; VWF_A.
DR   InterPro; IPR036465; vWFA_dom_sf.
DR   PANTHER; PTHR10579; CALCIUM-ACTIVATED CHLORIDE CHANNEL REGULATOR; 1.
DR   PANTHER; PTHR10579:SF43; LOW QUALITY PROTEIN: EPITHELIAL CHLORIDE CHANNEL PROTEIN-LIKE ISOFORM X1-RELATED; 1.
DR   Pfam; PF13519; VWA_2; 1.
DR   SMART; SM00327; VWA; 1.
DR   SUPFAM; SSF53300; vWA-like; 1.
DR   PROSITE; PS50234; VWFA; 1.
PE   4: Predicted;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000053923};
KW   Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   SIGNAL          1..28
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           29..423
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5038376322"
FT   TRANSMEM        391..412
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          39..224
FT                   /note="VWFA"
FT                   /evidence="ECO:0000259|PROSITE:PS50234"
SQ   SEQUENCE   423 AA;  44521 MW;  071FF81CFEB7E195 CRC64;
     MIRTQRLTAG VCALLAALTA GIAFPAGAVA DETTATAPKV DLVIDVSGSM RANDMDGQSR
     MAAAKQAFNE VLDATPEEVQ LGIRTLGANY PGDDRKTGCK DTAQLYPVGP LDRTEAKTAV
     ATLTPTGWTP IGPALLKAAE DLDGGEGSKR IVLISDGEDT CAPLDPCEVA REIAAKGIGL
     TIDTLGLVPN TKLRRQLSCI AEATGGTFTS VEHTDELADK VNQLVDRAAD PVVTPVATTG
     AEQCAKAPTL KSGLYTDREE FGQQRWYRVD VEPGQELRAS VSVSADRAVS PSYGVLLRAE
     TARGREIVRG EAAGNGRTDV ISTGLRYPKA QSDDEDEDTA TAETVCLQVT HSFSAGSGVQ
     ATPGLPLELT VDVVDGPSQS SDVASFGLGR GWWLLGALIL AGFLAGLVWG WLSRWRVAVW
     RTN
//