ID A0A0X3WDH1_9ACTN Unreviewed; 676 AA.
AC A0A0X3WDH1;
DT 13-APR-2016, integrated into UniProtKB/TrEMBL.
DT 13-APR-2016, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=site-specific DNA-methyltransferase (adenine-specific) {ECO:0000256|ARBA:ARBA00011900};
DE EC=2.1.1.72 {ECO:0000256|ARBA:ARBA00011900};
GN ORFNames=ADL22_02105 {ECO:0000313|EMBL:KUL54921.1};
OS Streptomyces sp. NRRL F-4489.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1609095 {ECO:0000313|EMBL:KUL54921.1, ECO:0000313|Proteomes:UP000053256};
RN [1] {ECO:0000313|EMBL:KUL54921.1, ECO:0000313|Proteomes:UP000053256}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NRRL F-4489 {ECO:0000313|EMBL:KUL54921.1,
RC ECO:0000313|Proteomes:UP000053256};
RA Gilbert D.G.;
RL Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine = an
CC N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-
CC homocysteine; Xref=Rhea:RHEA:15197, Rhea:RHEA-COMP:12418, Rhea:RHEA-
CC COMP:12419, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC ChEBI:CHEBI:90615, ChEBI:CHEBI:90616; EC=2.1.1.72;
CC Evidence={ECO:0000256|ARBA:ARBA00001279};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KUL54921.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; LLZI01000007; KUL54921.1; -; Genomic_DNA.
DR RefSeq; WP_066973187.1; NZ_LLZI01000007.1.
DR AlphaFoldDB; A0A0X3WDH1; -.
DR STRING; 1609095.ADL22_02105; -.
DR OrthoDB; 9784823at2; -.
DR Proteomes; UP000053256; Unassembled WGS sequence.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
DR GO; GO:0008170; F:N-methyltransferase activity; IEA:InterPro.
DR GO; GO:0009007; F:site-specific DNA-methyltransferase (adenine-specific) activity; IEA:UniProtKB-EC.
DR GO; GO:0009307; P:DNA restriction-modification system; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR022749; D12N6_MeTrfase_N.
DR InterPro; IPR003356; DNA_methylase_A-5.
DR InterPro; IPR002052; DNA_methylase_N6_adenine_CS.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR PANTHER; PTHR42933; SLR6095 PROTEIN; 1.
DR PANTHER; PTHR42933:SF3; TYPE I RESTRICTION ENZYME MJAVIII METHYLASE SUBUNIT; 1.
DR Pfam; PF12161; HsdM_N; 1.
DR Pfam; PF02384; N6_Mtase; 1.
DR PRINTS; PR00507; N12N6MTFRASE.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS00092; N6_MTASE; 1.
PE 4: Predicted;
KW Endonuclease {ECO:0000313|EMBL:KUL54921.1};
KW Hydrolase {ECO:0000313|EMBL:KUL54921.1};
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW Nuclease {ECO:0000313|EMBL:KUL54921.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000053256};
KW Restriction system {ECO:0000256|ARBA:ARBA00022747};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 7..137
FT /note="N6 adenine-specific DNA methyltransferase N-
FT terminal"
FT /evidence="ECO:0000259|Pfam:PF12161"
FT DOMAIN 149..453
FT /note="DNA methylase adenine-specific"
FT /evidence="ECO:0000259|Pfam:PF02384"
SQ SEQUENCE 676 AA; 75878 MW; D6D2905B9CFFE636 CRC64;
MSKNQELADF IWSVADLLRG DYKRSEYGKV ILPLTVLRRL DCVMAPTRQA VWDRAASYTG
ENKDGLLLAA SKLKFYNLSE QTFDTISSDA ANVAKNLKDY IRGFSSEATE IINRYEFHLQ
IDRLDNADLL YQVVRKFAGL DLSFEAVDNH DMGYVFEELI RKFADASNET AGEHFTPREV
IELMVELLLA PDDDRLNGEG QVVKIFDPAC GTGGMLSASE EHIRKLNPRV RVNLFGQELN
AESYAICRSD MLLKGHTAKN IRFGNSFSQD GHDGETFDYM LANPPFGVEW KKVEKVVRQE
HQDRGYDGRF GAGLPRINDG SLLFLQHMMS KMQPLKKDEA GDEAGGTRLA IVFNGSPLFT
GGAGSGESEI RKWIIEHDYL EAIVALPDQL FYNTGISTYF WIVTNRKPAD RKGRVILIDT
RDQWTKMRKS LGEKRKKITR PQIGRICALY RDALTIAGDE THQDHGRVKV FANRDFGYQR
ITVDRPLKLR FELTEDSLTQ LGASAAVRKA VGGEAAVESL LTALKPLLGS QWSTKAEAWD
DLRAAMVAGG VLWPTAAPFQ KAMRDAVGVT DPDGEVQVIK GKPEPDPELR DNENVPLGED
IDEYLARKVL PYVPDAWIAE TRNPKTKGTE RFKVGYEIPF TRHFYVYTPP RPLAEIDAEL
KSIEAEIQAL LGEVTG
//