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Entry: A0A0X8F884_9LACT
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ID   A0A0X8F884_9LACT        Unreviewed;       447 AA.
AC   A0A0X8F884;
DT   13-APR-2016, integrated into UniProtKB/TrEMBL.
DT   13-APR-2016, sequence version 1.
DT   05-JUL-2017, entry version 13.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|HAMAP-Rule:MF_00377, ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00724181};
GN   Name=dnaA {ECO:0000256|HAMAP-Rule:MF_00377};
GN   ORFNames=AWM71_03220 {ECO:0000313|EMBL:AMB92385.1}, HMPREF3187_01036
GN   {ECO:0000313|EMBL:KXB36119.1};
OS   Aerococcus christensenii.
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Aerococcaceae;
OC   Aerococcus.
OX   NCBI_TaxID=87541 {ECO:0000313|EMBL:AMB92385.1, ECO:0000313|Proteomes:UP000060400};
RN   [1] {ECO:0000313|EMBL:AMB92385.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=CCUG28831 {ECO:0000313|EMBL:AMB92385.1};
RX   PubMed=27103727;
RA   Carkaci D., Dargis R., Nielsen X.C., Skovgaard O., Fuursted K.,
RA   Christensen J.J.;
RT   "Complete Genome Sequences of Aerococcus christensenii CCUG 28831T,
RT   Aerococcus sanguinicola CCUG 43001T, Aerococcus urinae CCUG 36881T,
RT   Aerococcus urinaeequi CCUG 28094T, Aerococcus urinaehominis CCUG 42038
RT   BT, and Aerococcus viridans CCUG 4311T.";
RL   Genome Announc. 4:0-0(2016).
RN   [2] {ECO:0000313|Proteomes:UP000060400}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CCUG28831 {ECO:0000313|Proteomes:UP000060400};
RA   Carkaci D., Dargis R., Nielsen X.C., Skovgaard O., Fuursted K.,
RA   Christensen J.J.;
RT   "Six Aerococcus type strain genome sequencing and assembly using
RT   PacBio and Illumina Hiseq.";
RL   Submitted (JAN-2016) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|EMBL:KXB36119.1, ECO:0000313|Proteomes:UP000070422}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=KA00635 {ECO:0000313|EMBL:KXB36119.1,
RC   ECO:0000313|Proteomes:UP000070422};
RA   Oliw E.H.;
RL   Submitted (JAN-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00724167}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|SAAS:SAAS00756131}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00377, ECO:0000256|RuleBase:RU004227,
CC       ECO:0000256|SAAS:SAAS00555179}.
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DR   EMBL; CP014159; AMB92385.1; -; Genomic_DNA.
DR   EMBL; LSCQ01000048; KXB36119.1; -; Genomic_DNA.
DR   RefSeq; WP_060776636.1; NZ_KQ959308.1.
DR   EnsemblBacteria; AMB92385; AMB92385; AWM71_03220.
DR   EnsemblBacteria; KXB36119; KXB36119; HMPREF3187_01036.
DR   KEGG; acg:AWM71_03220; -.
DR   PATRIC; fig|87541.4.peg.1027; -.
DR   KO; K02313; -.
DR   Proteomes; UP000060400; Chromosome.
DR   Proteomes; UP000070422; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-HAMAP.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-HAMAP.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-HAMAP.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-HAMAP.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR024633; DnaA_N_dom.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF12; PTHR30050:SF12; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   Pfam; PF11638; DnaA_N; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731922};
KW   Complete proteome {ECO:0000313|Proteomes:UP000060400,
KW   ECO:0000313|Proteomes:UP000070422};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|SAAS:SAAS00756112};
KW   DNA replication {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU004227, ECO:0000256|SAAS:SAAS00731887};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00756124};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731897};
KW   Reference proteome {ECO:0000313|Proteomes:UP000060400}.
FT   DOMAIN      143    274       AAA. {ECO:0000259|SMART:SM00382}.
FT   DOMAIN      355    424       Bac_DnaA_C. {ECO:0000259|SMART:SM00760}.
FT   NP_BIND     151    158       ATP. {ECO:0000256|HAMAP-Rule:MF_00377}.
SQ   SEQUENCE   447 AA;  50838 MW;  E420E429FAABA3BB CRC64;
     MDPLQDLWQV VTEYFRNQLT KGSFDTWILG LKPLQLTQDT LTIEAVSQLH KKHIESHYLL
     QLKQVIYEYL GREIQINLVL DQSNNFNSQI QFGDNPSSTE VSRHTSNKSD LNPKYTFENF
     VVGEGNKMAH AAALAVAEGP GRDYNPLFFY GGVGLGKTHL MQAIGHEVLR TFPDARVKYV
     TSEKFTNDFI EAIRKNTTSQ FHEEYRNVDM LLVDDIQFIG NKQSTQEEFF HTFNALYNNN
     KHIVLTSDRD ASQIPELEDR LVSRFKQGLS TDITPPDLET RIAILRNKAQ VNGINIPDDT
     LSYIAGQIDT NIRELEGALT SVQAYAVMNQ ADLTPDVAAR ALSNYKDLNA NKVPTISEIQ
     EIVANFFHLT VEDLKGKKRK REIVVPRQIA MYLSREITDA SLPKIGQEFG GKDHTTVLHA
     HEKISEAMRH PSDIRDNIQS IERLLNH
//
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