ID A0A0X8FB88_9LACT Unreviewed; 624 AA.
AC A0A0X8FB88;
DT 13-APR-2016, integrated into UniProtKB/TrEMBL.
DT 13-APR-2016, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE SubName: Full=DNA methylase N-4 {ECO:0000313|EMBL:AMB94172.1};
DE SubName: Full=Site-specific DNA-methyltransferase {ECO:0000313|EMBL:PKZ22345.1};
GN ORFNames=AWM72_05085 {ECO:0000313|EMBL:AMB94172.1}, CYJ28_04315
GN {ECO:0000313|EMBL:PKZ22345.1};
OS Aerococcus sanguinicola.
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Aerococcaceae; Aerococcus.
OX NCBI_TaxID=119206 {ECO:0000313|EMBL:AMB94172.1, ECO:0000313|Proteomes:UP000069912};
RN [1] {ECO:0000313|EMBL:AMB94172.1, ECO:0000313|Proteomes:UP000069912}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CCUG43001 {ECO:0000313|EMBL:AMB94172.1,
RC ECO:0000313|Proteomes:UP000069912};
RX PubMed=27103727;
RA Carkaci D., Dargis R., Nielsen X.C., Skovgaard O., Fuursted K.,
RA Christensen J.J.;
RT "Complete Genome Sequences of Aerococcus christensenii CCUG 28831T,
RT Aerococcus sanguinicola CCUG 43001T, Aerococcus urinae CCUG 36881T,
RT Aerococcus urinaeequi CCUG 28094T, Aerococcus urinaehominis CCUG 42038 BT,
RT and Aerococcus viridans CCUG 4311T.";
RL Genome Announc. 4:0-0(2016).
RN [2] {ECO:0000313|Proteomes:UP000069912}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CCUG43001 {ECO:0000313|Proteomes:UP000069912};
RA Carkaci D., Dargis R., Nielsen X.C., Skovgaard O., Fuursted K.,
RA Christensen J.J.;
RT "Six Aerococcus type strain genome sequencing and assembly using PacBio and
RT Illumina Hiseq.";
RL Submitted (JAN-2016) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:PKZ22345.1, ECO:0000313|Proteomes:UP000234239}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=UMB0139 {ECO:0000313|EMBL:PKZ22345.1,
RC ECO:0000313|Proteomes:UP000234239};
RA Thomas-White K., Wolfe A.J.;
RT "Phylogenetic diversity of female urinary microbiome.";
RL Submitted (DEC-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the N(4)/N(6)-methyltransferase family.
CC {ECO:0000256|ARBA:ARBA00006594}.
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DR EMBL; CP014160; AMB94172.1; -; Genomic_DNA.
DR EMBL; PKGY01000002; PKZ22345.1; -; Genomic_DNA.
DR RefSeq; WP_067974220.1; NZ_PKGY01000002.1.
DR AlphaFoldDB; A0A0X8FB88; -.
DR REBASE; 137641; M.Asa43001I.
DR GeneID; 69593015; -.
DR KEGG; asan:AWM72_05085; -.
DR OrthoDB; 9800801at2; -.
DR Proteomes; UP000069912; Chromosome.
DR Proteomes; UP000234239; Unassembled WGS sequence.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0008170; F:N-methyltransferase activity; IEA:InterPro.
DR GO; GO:0006306; P:DNA methylation; IEA:InterPro.
DR GO; GO:0009307; P:DNA restriction-modification system; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR002941; DNA_methylase_N4/N6.
DR InterPro; IPR002052; DNA_methylase_N6_adenine_CS.
DR InterPro; IPR002295; N4/N6-MTase_EcoPI_Mod-like.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR PANTHER; PTHR13370; RNA METHYLASE-RELATED; 1.
DR PANTHER; PTHR13370:SF16; TYPE III RESTRICTION-MODIFICATION ENZYME STYLTI MOD SUBUNIT; 1.
DR Pfam; PF01555; N6_N4_Mtase; 1.
DR PIRSF; PIRSF015855; TypeIII_Mtase_mKpnI; 1.
DR PRINTS; PR00506; D21N6MTFRASE.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS00092; N6_MTASE; 1.
PE 3: Inferred from homology;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603,
KW ECO:0000313|EMBL:AMB94172.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000069912};
KW Restriction system {ECO:0000256|ARBA:ARBA00022747};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:PKZ22345.1}.
FT DOMAIN 113..424
FT /note="DNA methylase N-4/N-6"
FT /evidence="ECO:0000259|Pfam:PF01555"
SQ SEQUENCE 624 AA; 70776 MW; 17510585FD74EDAB CRC64;
MTNQVPSGSL DLTQNNIEKL KELFPEVITD GGKIDFETLQ TILGEEIDDE GERYSFTWPG
KRESILGSQL PSKGTLRPNV DKSKDFDHTG NLYIEGDNLE VLKLLQKSYN SKVKVIYIDP
PYNTGKDFVY KDDFREGVEN YLEQTGQVDS DGNLLSTNSE SNGRFHTDWL NMMYPRLRLA
RNLLAEDGVI FISIDDGEVA NLKKVCSEIF GEKNFLAQVI WERAYAPVNL KKNFSESHDF
ILVYGKNTDG LESNGIARSD RQIDSYINPD NDPRGIYKPD NFTVGPAVEK NIYEITTPSG
RVVLPPNGYS WRFSKERFNE LLSDNRVWFG KDGNNVPAYK RFLSEVKSGV TPMTIWKYDD
VGHSQSATKY LRNLMDGKAY FDYPKPVDLI KRCIELYSEP DSIVLDFFAG SATTAEAVMK
KNAEDSGSRK YIMVQLPEVL EESSTAYKDG YRNLTDIAVE RIRRAGDKII DENPELADTL
DIGFKYFQLD KSNIQEWNPD FEDLENDKVN LFEDVFVEGR SELDIVYEIM LKNGLELILP
ITTFEIEGKI VYDIAYGSQF ICLAHGIDLA VAEGIITKRD DYDSQLISGV VFKDKGFKGN
DAMKLNVIQA LVDADFAEEA IQTI
//
