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Database: UniProt
Entry: A0A0X8VAR0_CLOPR
LinkDB: A0A0X8VAR0_CLOPR
Original site: A0A0X8VAR0_CLOPR 
ID   A0A0X8VAR0_CLOPR        Unreviewed;       442 AA.
AC   A0A0X8VAR0;
DT   13-APR-2016, integrated into UniProtKB/TrEMBL.
DT   13-APR-2016, sequence version 1.
DT   27-SEP-2017, entry version 13.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|HAMAP-Rule:MF_00377, ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00724181};
GN   Name=dnaA {ECO:0000256|HAMAP-Rule:MF_00377,
GN   ECO:0000313|EMBL:AMJ39629.1};
GN   ORFNames=CPRO_00010 {ECO:0000313|EMBL:AMJ39629.1};
OS   [Clostridium] propionicum DSM 1682.
OC   Bacteria; Firmicutes; Clostridia; Clostridiales; Lachnospiraceae;
OC   Tyzzerella.
OX   NCBI_TaxID=991789 {ECO:0000313|EMBL:AMJ39629.1, ECO:0000313|Proteomes:UP000068026};
RN   [1] {ECO:0000313|Proteomes:UP000068026}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=X2 {ECO:0000313|Proteomes:UP000068026};
RA   McClelland M., Jain A., Saraogi P., Mendelson R., Westerman R.,
RA   SanMiguel P., Csonka L.;
RL   Submitted (JAN-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00724167}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|SAAS:SAAS00756131}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00377, ECO:0000256|RuleBase:RU004227,
CC       ECO:0000256|SAAS:SAAS00555179}.
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DR   EMBL; CP014223; AMJ39629.1; -; Genomic_DNA.
DR   RefSeq; WP_066046470.1; NZ_FQUA01000001.1.
DR   EnsemblBacteria; AMJ39629; AMJ39629; CPRO_00010.
DR   KEGG; cpro:CPRO_00010; -.
DR   PATRIC; fig|991789.3.peg.1; -.
DR   KO; K02313; -.
DR   Proteomes; UP000068026; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-UniRule.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-UniRule.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR024633; DnaA_N_dom.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF12; PTHR30050:SF12; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   Pfam; PF11638; DnaA_N; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731922};
KW   Complete proteome {ECO:0000313|Proteomes:UP000068026};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|SAAS:SAAS00756112};
KW   DNA replication {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU004227, ECO:0000256|SAAS:SAAS00731887};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00756124};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731897}.
FT   NP_BIND     145    152       ATP. {ECO:0000256|HAMAP-Rule:MF_00377}.
SQ   SEQUENCE   442 AA;  50457 MW;  327DC2F5B0A7AED2 CRC64;
     MEQINELWNE ALKIIEEESS AVSFETWFRP IVPYGLQDHC LYLQVDNPLA KDMLEKRYFD
     LLKNTIKQVT KTDLEIIILM GNELPVKLME KKEVQKQGTE IPRNLNPKYV FSSFVVGNSN
     RMAHAASLAV AEAPAKNYNP LFLYGNSGLG KTHLMHSIAH YILDNNSSAK VLYVTSETFT
     NELILSIQNN RNEAFRNKYR NIDVLLIDDI QFISKKEGTQ EEFFHTFNAL YESTKQIIIS
     SDRPPKEIET LEDRLRSRFE MGLIADIQPP DYETRIAILR KKAERDNLQV PDDVLAYIAK
     NIASNIRELE GALTRIVAFA TLTNQDISIF LAENSLKDIF SENASAPITP DSIQEIVAEH
     FNIRIEDIQG SKKPKNIAFP RQISMYLCRK LLDISLPKIG ESFGGRDHTT VIHAISKIEK
     QLENDTALQN TILQLEKVIK GQ
//
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