ID A0A100IEJ1_ASPNG Unreviewed; 451 AA.
AC A0A100IEJ1;
DT 13-APR-2016, integrated into UniProtKB/TrEMBL.
DT 13-APR-2016, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=Fructose-2,6-bisphosphatase {ECO:0000313|EMBL:GAQ39780.1};
GN ORFNames=ABL_03316 {ECO:0000313|EMBL:GAQ39780.1};
OS Aspergillus niger.
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Circumdati.
OX NCBI_TaxID=5061 {ECO:0000313|EMBL:GAQ39780.1, ECO:0000313|Proteomes:UP000068243};
RN [1] {ECO:0000313|Proteomes:UP000068243}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=An76 {ECO:0000313|Proteomes:UP000068243};
RX PubMed=26893421; DOI=10.1128/genomeA.01700-15;
RA Gong W., Cheng Z., Zhang H., Liu L., Gao P., Wang L.;
RT "Draft genome sequence of Aspergillus niger strain An76.";
RL Genome Announc. 4:E0170015-E0170015(2016).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:GAQ39780.1}.
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DR EMBL; BCMY01000004; GAQ39780.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A100IEJ1; -.
DR PaxDb; 5061-CADANGAP00005374; -.
DR VEuPathDB; FungiDB:An07g02100; -.
DR VEuPathDB; FungiDB:ASPNIDRAFT2_1087026; -.
DR VEuPathDB; FungiDB:ATCC64974_44700; -.
DR VEuPathDB; FungiDB:M747DRAFT_244416; -.
DR OMA; RWIQERC; -.
DR Proteomes; UP000068243; Unassembled WGS sequence.
DR GO; GO:0003873; F:6-phosphofructo-2-kinase activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0006003; P:fructose 2,6-bisphosphate metabolic process; IEA:InterPro.
DR GO; GO:0006000; P:fructose metabolic process; IEA:InterPro.
DR CDD; cd07067; HP_PGM_like; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.40.50.1240; Phosphoglycerate mutase-like; 1.
DR InterPro; IPR003094; 6Pfruct_kin.
DR InterPro; IPR013079; 6Phosfructo_kin.
DR InterPro; IPR013078; His_Pase_superF_clade-1.
DR InterPro; IPR029033; His_PPase_superfam.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR001345; PG/BPGM_mutase_AS.
DR PANTHER; PTHR10606:SF44; 6-PHOSPHOFRUCTO 2-KINASE_FRUCTOSE 2,6-BISPHOSPHATASE LONG FORM; 1.
DR PANTHER; PTHR10606; 6-PHOSPHOFRUCTO-2-KINASE/FRUCTOSE-2,6-BISPHOSPHATASE; 1.
DR Pfam; PF01591; 6PF2K; 1.
DR Pfam; PF00300; His_Phos_1; 1.
DR PIRSF; PIRSF000709; 6PFK_2-Ptase; 1.
DR PRINTS; PR00991; 6PFRUCTKNASE.
DR SMART; SM00855; PGAM; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF53254; Phosphoglycerate mutase-like; 1.
DR PROSITE; PS00175; PG_MUTASE; 1.
PE 4: Predicted;
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741}.
FT DOMAIN 17..230
FT /note="6-phosphofructo-2-kinase"
FT /evidence="ECO:0000259|Pfam:PF01591"
FT ACT_SITE 238
FT /note="Tele-phosphohistidine intermediate"
FT /evidence="ECO:0000256|PIRSR:PIRSR613078-1"
FT ACT_SITE 314
FT /note="Proton donor/acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR613078-1"
FT BINDING 237..244
FT /ligand="substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR613078-2"
FT BINDING 290
FT /ligand="substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR613078-2"
SQ SEQUENCE 451 AA; 51319 MW; 074FD2FB59F8D5C7 CRC64;
MSSGSIRRGN GHNYFASSDD SKICVVMVGL PARGKSLIAG KAMRYLAWVG IPARVFNVGS
YRRAGTPQPN ANFFDPHNTE GEKMRRAAAE AAVSDMLQWF QSGKGVVAIL DATNSTKERR
RWIHERCQEA NVETLYVESI CDDEDLIMNN ILEVKTTSPD YKGQDPEVAA LDFRNRIRNY
EKVYETIDDN EKHFTYVKLI NVGSTVIINQ IKDYLSSRLV YYIQNLHIKP RSIWLSRHGE
SEYNLTGKIG GDSNISERGE AYARALPGLL KKSGVPPNTK IVIWTSTLKR TIQTARHLAA
ETGFEKLEWK ALDELDSGVC DGLTYEQIAE KYPEDFAARD EDKYNYRYRG GESYRDVVIR
LEPIIMELER SENVIIVTHQ AVLRCIYAYF LNTPQEQSPW MEVPLHTLIK LTPRAYGTDE
QRFKADIPAV STWRAKGTSA KHQEYPTEIK A
//
