ID   A0A100W4L0_9MYCO        Unreviewed;       951 AA.
AC   A0A100W4L0;
DT   13-APR-2016, integrated into UniProtKB/TrEMBL.
DT   13-APR-2016, sequence version 1.
DT   27-MAR-2024, entry version 34.
DE   SubName: Full=Transport protein {ECO:0000313|EMBL:GAS91522.1};
GN   ORFNames=RMCB_5618 {ECO:0000313|EMBL:GAS91522.1};
OS   Mycolicibacterium brisbanense.
OC   Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Mycobacteriaceae;
OC   Mycolicibacterium.
OX   NCBI_TaxID=146020 {ECO:0000313|EMBL:GAS91522.1, ECO:0000313|Proteomes:UP000069620};
RN   [1] {ECO:0000313|EMBL:GAS91522.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JCM15654 {ECO:0000313|EMBL:GAS91522.1};
RA   Katahira K., Ogura Y., Gotoh Y., Hayashi T.;
RT   "Draft Genome Sequences of Five Rapidly Growing Mycobacterium Species, M.
RT   thermoresistibile, M. fortuitum subsp. acetamidolyticum, M. canariasense,
RT   M. brisbanense, and M. novocastrense.";
RL   Genome Announc. 4:e00322-16(2016).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the resistance-nodulation-cell division (RND)
CC       (TC 2.A.6) family. MmpL subfamily. {ECO:0000256|ARBA:ARBA00010157}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:GAS91522.1}.
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DR   EMBL; BCSX01000049; GAS91522.1; -; Genomic_DNA.
DR   RefSeq; WP_029370947.1; NZ_JACKTM010000021.1.
DR   AlphaFoldDB; A0A100W4L0; -.
DR   STRING; 146020.RMCB_5618; -.
DR   OrthoDB; 4656631at2; -.
DR   Proteomes; UP000069620; Unassembled WGS sequence.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR   InterPro; IPR004869; MMPL_dom.
DR   InterPro; IPR004707; MmpL_fam.
DR   NCBIfam; TIGR00833; actII; 1.
DR   PANTHER; PTHR33406; MEMBRANE PROTEIN MJ1562-RELATED; 1.
DR   PANTHER; PTHR33406:SF6; MEMBRANE PROTEIN SCO0839-RELATED; 1.
DR   Pfam; PF03176; MMPL; 2.
DR   SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
PE   3: Inferred from homology;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        21..40
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        202..228
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        248..272
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        293..317
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        329..351
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        372..398
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        766..784
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        791..813
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        825..848
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        860..880
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          53..383
FT                   /note="Membrane transport protein MMPL"
FT                   /evidence="ECO:0000259|Pfam:PF03176"
FT   DOMAIN          604..938
FT                   /note="Membrane transport protein MMPL"
FT                   /evidence="ECO:0000259|Pfam:PF03176"
SQ   SEQUENCE   951 AA;  104019 MW;  205E56686386F587 CRC64;
     MADPSKSTTT HTGVARWIRR LAVPIILGWI GLVVVLNMTV PQLEAVAQMR SVSMSPDEAP
     SVIAMKRVGV VFDEFHSDSS AMIVLEGDKP LGDDAHYFYN DMVAKLKADT KHVEHVQDFW
     GDPLTKAGAQ SNDLRAAYVQ VYLVGNMGET IANESVESVQ KLVKGLSPPP GVQVYVTGPT
     ALAADQQISA DRSVQMIEMV TFVVIITMLL LVYRSVITVI IVLAMVVLEL SAARGVVAFL
     GYHNLIGLTP FATQLLVTLA IAAATDYAIF LIGRYQEARG NGEDREQAYY TMFHGTAHVV
     LGSGMTIAGA TFCLHFTRLP YFQSLGIPMA VGMVVAVFAA LTLGPALVTV TSRFGRTLEP
     RRAMRIRGWR RLGAFVVRWP GPVLLGTILL SLVGLLTLPG YRTNYNDRNY LPADLPANAG
     YAAAERHFSP AKMNPELLLI ETDHDVRNSA DFLVIDKIAK AIFQVPGIGS VQAITRPDGK
     PLKFSTIPAQ MSMGGVMQTM NRKYLTDRAN DMLLQADDMQ KTVDIMDRMI TLMEEMSATT
     HSMVGKTHDM VTDVAELRDS ISDFDDFLRP LRNYLYWEPH CYDIPVCWSL RSVFDGLDGV
     DTMTAAIQEL LPDMDRLDAL MPQMAAMMQP QIETMKHTKT MMLTMYQTQK GLQDQMAAMQ
     DGQSAMGDAF NDSKNDDTFY LPPETFNNSD FKRGMKSFIS PDGKAVRFMI SHEGDPLTAD
     GIKLIDGIKL AAKEAMKNTP FEGSKIYLGG TAATFKDMQE GNNYDLIIAG ISALSLIFII
     MLLITRSLVA AAVIVGTVLV SLGTSFGLSV LVWQHLIGIE LHFMVMAMAV IVLLAVGADY
     NLLLVARLKE ELPAGINTGI IRAMGGSGSV VTAAGLVFAF TMMSMVVSEM TVVAQVGSTI
     GLGLLFDTLV IRSFMTPSIA ALMGRWFWWP QMVRQRPAQG VVARALERSS S
//