GenomeNet

Database: UniProt
Entry: A0A100Y3K6_9ACTN
LinkDB: A0A100Y3K6_9ACTN
Original site: A0A100Y3K6_9ACTN 
ID   A0A100Y3K6_9ACTN        Unreviewed;       598 AA.
AC   A0A100Y3K6;
DT   13-APR-2016, integrated into UniProtKB/TrEMBL.
DT   13-APR-2016, sequence version 1.
DT   25-OCT-2017, entry version 15.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|HAMAP-Rule:MF_00377, ECO:0000256|RuleBase:RU000577};
GN   Name=dnaA {ECO:0000256|HAMAP-Rule:MF_00377,
GN   ECO:0000313|EMBL:KUH37079.1};
GN   ORFNames=ATE80_19985 {ECO:0000313|EMBL:KUH37079.1};
OS   Streptomyces kanasensis.
OC   Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
OC   Streptomyces.
OX   NCBI_TaxID=936756 {ECO:0000313|EMBL:KUH37079.1, ECO:0000313|Proteomes:UP000054011};
RN   [1] {ECO:0000313|EMBL:KUH37079.1, ECO:0000313|Proteomes:UP000054011}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ZX01 {ECO:0000313|EMBL:KUH37079.1,
RC   ECO:0000313|Proteomes:UP000054011};
RA   Zhang G., Han L., Feng J., Zhang X.;
RT   "Genome-wide analysis reveals the secondary metabolome in Streptomyces
RT   kanasensis ZX01.";
RL   Submitted (NOV-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00735475}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|SAAS:SAAS00911680}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00377, ECO:0000256|RuleBase:RU004227,
CC       ECO:0000256|SAAS:SAAS00555179}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:KUH37079.1}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; LNSV01000055; KUH37079.1; -; Genomic_DNA.
DR   EnsemblBacteria; KUH37079; KUH37079; ATE80_19985.
DR   Proteomes; UP000054011; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-UniRule.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-UniRule.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF2; PTHR30050:SF2; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00747950};
KW   Complete proteome {ECO:0000313|Proteomes:UP000054011};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|SAAS:SAAS00911664};
KW   DNA replication {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU004227, ECO:0000256|SAAS:SAAS00747996};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00911684};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00747895};
KW   Reference proteome {ECO:0000313|Proteomes:UP000054011}.
FT   DOMAIN      291    419       AAA. {ECO:0000259|SMART:SM00382}.
FT   DOMAIN      505    574       Bac_DnaA_C. {ECO:0000259|SMART:SM00760}.
FT   NP_BIND     299    306       ATP. {ECO:0000256|HAMAP-Rule:MF_00377}.
SQ   SEQUENCE   598 AA;  65915 MW;  914AE0D60B72A7F8 CRC64;
     MLEHLLGEGQ QGIEPKDKQW IERCQPLALV ADTALLAVPN EWGKRVLEGR LAPLISDTLS
     RECGRPIRIA ITVDDSAGDQ APLPPGPERH QSHQPQQSRY DERGQGESYD AYGRPTDDGL
     PSVRPAYPDY QQQRPEPGAW PRAQEDLSWQ QPRLGGFQDR DPYATARPQQ PHHDYGTPPG
     PEHGGYDSRR AERRDLPDHQ GQHQHRPGGP SGSGGPGGRG GAGDRGQAPG HGSMGGPGSM
     GGTGGGSRPG APGEQHARLN PKYLFDTFVI GSSNRFAHAA AVAVAEAPAK AYNPLFIYGE
     SGLGKTHLLH AIGHYARSLY PGTRVRYVSS EEFTNEFINS IRDGKGDTFR KRYRDVDILL
     VDDIQFLASK ESTQEEFFHT FNTLHNANKQ IVLSSDRPPK QLMTLEDRLR NRFEWGLTTD
     VQPPELETRI AILRKKAVQE QLNAPPEVLE FIASRISRNI RELEGALIRV TAFASLNRQP
     VDLVLTESVL KDLIPGGEDS APEITAGAIM AATADYFGLT VEDLCGSSRS RVLVTARQIA
     MYLCRELTDL SLPKIGAQFG GRDHTTVMHA DRKIRALMAE RRSIYNQVTE LTNRIKNG
//
DBGET integrated database retrieval system