ID A0A101H9C0_9FIRM Unreviewed; 403 AA.
AC A0A101H9C0;
DT 13-APR-2016, integrated into UniProtKB/TrEMBL.
DT 13-APR-2016, sequence version 1.
DT 24-JAN-2024, entry version 30.
DE RecName: Full=Arginine deiminase {ECO:0000256|HAMAP-Rule:MF_00242};
DE Short=ADI {ECO:0000256|HAMAP-Rule:MF_00242};
DE EC=3.5.3.6 {ECO:0000256|HAMAP-Rule:MF_00242};
DE AltName: Full=Arginine dihydrolase {ECO:0000256|HAMAP-Rule:MF_00242};
DE Short=AD {ECO:0000256|HAMAP-Rule:MF_00242};
GN Name=arcA {ECO:0000256|HAMAP-Rule:MF_00242};
GN ORFNames=XD91_1270 {ECO:0000313|EMBL:KUK72527.1};
OS Clostridiales bacterium 38_11.
OC Bacteria; Bacillota; Clostridia; Eubacteriales.
OX NCBI_TaxID=1641393 {ECO:0000313|EMBL:KUK72527.1, ECO:0000313|Proteomes:UP000053314};
RN [1] {ECO:0000313|Proteomes:UP000053314}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=26787827; DOI=10.1128/mbio.01669-15;
RA Hu P., Tom L., Singh A., Thomas B.C., Baker B.J., Piceno Y.M.,
RA Andersen G.L., Banfield J.F.;
RT "Genome-Resolved Metagenomic Analysis Reveals Roles for Candidate Phyla and
RT Other Microbial Community Members in Biogeochemical Transformations in Oil
RT Reservoirs.";
RL MBio 7:e01669-15(2015).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + L-arginine = L-citrulline + NH4(+);
CC Xref=Rhea:RHEA:19597, ChEBI:CHEBI:15377, ChEBI:CHEBI:28938,
CC ChEBI:CHEBI:32682, ChEBI:CHEBI:57743; EC=3.5.3.6;
CC Evidence={ECO:0000256|ARBA:ARBA00001190, ECO:0000256|HAMAP-
CC Rule:MF_00242};
CC -!- PATHWAY: Amino-acid degradation; L-arginine degradation via ADI
CC pathway; carbamoyl phosphate from L-arginine: step 1/2.
CC {ECO:0000256|ARBA:ARBA00005213, ECO:0000256|HAMAP-Rule:MF_00242}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00242}.
CC -!- SIMILARITY: Belongs to the arginine deiminase family.
CC {ECO:0000256|ARBA:ARBA00010206, ECO:0000256|HAMAP-Rule:MF_00242}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KUK72527.1}.
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DR EMBL; LGGM01000054; KUK72527.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A101H9C0; -.
DR PATRIC; fig|1641393.3.peg.3; -.
DR UniPathway; UPA00254; UER00364.
DR Proteomes; UP000053314; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0016990; F:arginine deiminase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0019547; P:arginine catabolic process to ornithine; IEA:UniProtKB-UniPathway.
DR Gene3D; 1.10.3930.10; Arginine deiminase; 1.
DR HAMAP; MF_00242; Arg_deiminase; 1.
DR InterPro; IPR003876; Arg_deiminase.
DR NCBIfam; TIGR01078; arcA; 1.
DR PANTHER; PTHR47271; ARGININE DEIMINASE; 1.
DR PANTHER; PTHR47271:SF2; ARGININE DEIMINASE; 1.
DR Pfam; PF02274; ADI; 1.
DR PIRSF; PIRSF006356; Arg_deiminase; 1.
DR PRINTS; PR01466; ARGDEIMINASE.
DR SUPFAM; SSF55909; Pentein; 1.
PE 3: Inferred from homology;
KW Arginine metabolism {ECO:0000256|ARBA:ARBA00022503, ECO:0000256|HAMAP-
KW Rule:MF_00242}; Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00242};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|HAMAP-Rule:MF_00242}.
FT ACT_SITE 395
FT /note="Amidino-cysteine intermediate"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00242,
FT ECO:0000256|PIRSR:PIRSR006356-1"
SQ SEQUENCE 403 AA; 46802 MW; 5D4FBCE0B4EDC188 CRC64;
MKPIHVTSEI GRLKKVLLHR PGQEIENLMP EYLERLLFDD IPYLKIAQEE HDEFANILRS
NGVEVVYLED LATESIKDSA VKEAFIEEYL DEANIWNKRR FDGLKQYFME MEEKELVAKM
MAGLRKNDFI NFSKRGLKDY LDNDYPFIID PMPNLYFTRD PFASIASGIS LHRMKTFTRN
RETLFTKYII NHHPDFSPHK IPLWYDRTDK FSLEGGDILI LNENIIAVGI SQRTDPVAIE
IFAERILTSE NEFNRILAFD IPKSRSFMHL DTVFTMVDHN KFTIHPNIQQ TITVYSLTLQ
DGKIEIDEER DLLENILSKY LEIDNVELIK CGGNSMIDAA REQWNDGSNT LAISPGEVVV
YSRNYVTNQL LEERGIKTYV MPSSELSRGR GGPRCMSMPL IRE
//
