ID A0A101IFX4_9BACT Unreviewed; 817 AA.
AC A0A101IFX4;
DT 13-APR-2016, integrated into UniProtKB/TrEMBL.
DT 13-APR-2016, sequence version 1.
DT 24-JAN-2024, entry version 31.
DE RecName: Full=DNA mismatch repair protein MutS {ECO:0000256|HAMAP-Rule:MF_00096};
GN Name=mutS {ECO:0000256|HAMAP-Rule:MF_00096};
GN ORFNames=XE05_0576 {ECO:0000313|EMBL:KUK94458.1};
OS Thermotogales bacterium 46_20.
OC Bacteria; Thermotogota; Thermotogae; Thermotogales.
OX NCBI_TaxID=1635293 {ECO:0000313|EMBL:KUK94458.1, ECO:0000313|Proteomes:UP000054930};
RN [1] {ECO:0000313|Proteomes:UP000054930}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=26787827; DOI=10.1128/mbio.01669-15;
RA Hu P., Tom L., Singh A., Thomas B.C., Baker B.J., Piceno Y.M.,
RA Andersen G.L., Banfield J.F.;
RT "Genome-Resolved Metagenomic Analysis Reveals Roles for Candidate Phyla and
RT Other Microbial Community Members in Biogeochemical Transformations in Oil
RT Reservoirs.";
RL MBio 7:e01669-15(2015).
CC -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC It is possible that it carries out the mismatch recognition step. This
CC protein has a weak ATPase activity. {ECO:0000256|HAMAP-Rule:MF_00096}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC {ECO:0000256|ARBA:ARBA00006271, ECO:0000256|HAMAP-Rule:MF_00096,
CC ECO:0000256|RuleBase:RU003756}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KUK94458.1}.
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DR EMBL; LGGZ01000017; KUK94458.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A101IFX4; -.
DR PATRIC; fig|1635293.3.peg.1145; -.
DR Proteomes; UP000054930; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR CDD; cd03284; ABC_MutS1; 1.
DR Gene3D; 1.10.1420.10; -; 2.
DR Gene3D; 3.40.1170.10; DNA repair protein MutS, domain I; 1.
DR Gene3D; 3.30.420.110; MutS, connector domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR HAMAP; MF_00096; MutS; 1.
DR InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR InterPro; IPR036678; MutS_con_dom_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR NCBIfam; TIGR01070; mutS1; 1.
DR PANTHER; PTHR11361:SF34; DNA MISMATCH REPAIR PROTEIN MSH1, MITOCHONDRIAL; 1.
DR PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR Pfam; PF01624; MutS_I; 1.
DR Pfam; PF05188; MutS_II; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF05190; MutS_IV; 1.
DR Pfam; PF00488; MutS_V; 1.
DR PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF55271; DNA repair protein MutS, domain I; 1.
DR SUPFAM; SSF53150; DNA repair protein MutS, domain II; 1.
DR SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|HAMAP-
KW Rule:MF_00096}.
FT DOMAIN 672..688
FT /note="DNA mismatch repair proteins mutS family"
FT /evidence="ECO:0000259|PROSITE:PS00486"
FT BINDING 598..605
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00096"
SQ SEQUENCE 817 AA; 91380 MW; 20E93C8092A0F8F1 CRC64;
MTPMMEQYLR IKERYKDCLL LFRLGDFYEA FFEDAEQLSS VLRIVLTSRN GNPMAGIPYH
ALSQYLKKLV DAGLKVAICE QVGDPSKSQG LVKREVTRVI TPGTLIDEEL LSEENNFLMI
VSSGKSGYSF AITDISTGQL LVGSCSNIEE IEDRIASFSP SQVLFQRSLK ELSKEILGNR
PCSFVEYVED WHFALTSGVE YVKRVYGISS LEALELSEDE TALLGALFKY VENSNKGLFK
HFYLPAKQRA SDHMLIDSVT LSNLSLLTGD PGSSLFDSIK ETTTPMGTRL LKERIRRPSR
SLQEIEERLD RVEALVHDRR ATMELRQFLS HVSDIERITA RLVAGRSSPR DMKDLSTTLF
HVPDIASVIS RFEAFDKLVT SLPDLSEVAQ FINGAIQDDP AASPGEGGVI RRGFSTELDE
LVEILSGANS KMKEFQESQK AATGIPGLKV KYNKVFGYFI EVPRSQSGKI PPDYERKQTL
VNAERFINSE LKEYEEKLLS AGERLEQLER DLFVEVCESV AKNVEGFQAT AMILAEIDVA
LSSALLALKR HYTRPHFNEC NLLCLKASRH PVVERFVESF VPNEAEFFQD KRFAVLTGPN
MSGKSTYLRQ LGLIAIMAQS GSFVPAEEAN LPVYDRIFTR IGARDDLVAG KSTFLVEMLE
TASILINATE NSLVLLDEVG RGTSTFDGIS IAWAVSEYIY EVIGCHTMFA THFTELTEMA
EMYPGVVNLN VRIEEQGDSI VFLHKVAEGV ADRSYGIDVA KLAGIPQSVI DRSREILGII
LRTSSLDKAV RVLTADEVKE IKRTKKEKGS RDQIRLF
//
