ID A0A101JFH3_9ACTN Unreviewed; 295 AA.
AC A0A101JFH3;
DT 13-APR-2016, integrated into UniProtKB/TrEMBL.
DT 13-APR-2016, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=Oxidoreductase {ECO:0000313|EMBL:KUL25865.1};
GN ORFNames=ADL15_39875 {ECO:0000313|EMBL:KUL25865.1};
OS Actinoplanes awajinensis subsp. mycoplanecinus.
OC Bacteria; Actinomycetota; Actinomycetes; Micromonosporales;
OC Micromonosporaceae; Actinoplanes.
OX NCBI_TaxID=135947 {ECO:0000313|EMBL:KUL25865.1, ECO:0000313|Proteomes:UP000053244};
RN [1] {ECO:0000313|EMBL:KUL25865.1, ECO:0000313|Proteomes:UP000053244}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NRRL B-16712 {ECO:0000313|EMBL:KUL25865.1,
RC ECO:0000313|Proteomes:UP000053244};
RA Gilbert D.G.;
RL Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KUL25865.1}.
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DR EMBL; LLZH01000310; KUL25865.1; -; Genomic_DNA.
DR RefSeq; WP_067703023.1; NZ_LLZH01000310.1.
DR AlphaFoldDB; A0A101JFH3; -.
DR OrthoDB; 9804790at2; -.
DR Proteomes; UP000053244; Unassembled WGS sequence.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR GO; GO:0071704; P:organic substance metabolic process; IEA:UniProt.
DR GO; GO:0044281; P:small molecule metabolic process; IEA:UniProt.
DR Gene3D; 3.20.20.100; NADP-dependent oxidoreductase domain; 1.
DR InterPro; IPR020471; AKR.
DR InterPro; IPR018170; Aldo/ket_reductase_CS.
DR InterPro; IPR023210; NADP_OxRdtase_dom.
DR InterPro; IPR036812; NADP_OxRdtase_dom_sf.
DR PANTHER; PTHR43827; 2,5-DIKETO-D-GLUCONIC ACID REDUCTASE; 1.
DR PANTHER; PTHR43827:SF3; ALDO-KETO REDUCTASE; 1.
DR Pfam; PF00248; Aldo_ket_red; 1.
DR PIRSF; PIRSF000097; AKR; 1.
DR PRINTS; PR00069; ALDKETRDTASE.
DR SUPFAM; SSF51430; NAD(P)-linked oxidoreductase; 1.
DR PROSITE; PS00798; ALDOKETO_REDUCTASE_1; 1.
DR PROSITE; PS00062; ALDOKETO_REDUCTASE_2; 1.
DR PROSITE; PS00063; ALDOKETO_REDUCTASE_3; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000053244}.
FT DOMAIN 24..271
FT /note="NADP-dependent oxidoreductase"
FT /evidence="ECO:0000259|Pfam:PF00248"
FT ACT_SITE 51
FT /note="Proton donor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000097-1"
FT BINDING 109
FT /ligand="substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR000097-2"
FT SITE 76
FT /note="Lowers pKa of active site Tyr"
FT /evidence="ECO:0000256|PIRSR:PIRSR000097-3"
SQ SEQUENCE 295 AA; 32062 MW; D72E107F96D7D2F1 CRC64;
MPTVPNLTLN NGVEIPAIGL GVFQTPPDET RAAVQAALSS GYRHIDTAAA YGNEREVGEA
IVSSGVDRSE VFIETKIWIS DYGYDATLHG FDKSAAKLGV DQVDLLILHQ ALPSDFDKTL
DAYRALEKLY ADGKVRAIGV SNFMVDHLTA LLEKATVVPA VNQIEVHPYF AQREVQDLGA
KHHILTQAWS PIGGITFYRD SEHTSTLQDP VIGEIAQAHG KSPAQVMLRW HLQQGRQVIP
KSTKPARIAE NFAVFDFDLS AEQLATIDAL DTGKRGGPEP AAITLANFGR EIPEA
//
