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Database: UniProt
Entry: A0A101JGU0_9ACTN
LinkDB: A0A101JGU0_9ACTN
Original site: A0A101JGU0_9ACTN 
ID   A0A101JGU0_9ACTN        Unreviewed;       615 AA.
AC   A0A101JGU0;
DT   13-APR-2016, integrated into UniProtKB/TrEMBL.
DT   13-APR-2016, sequence version 1.
DT   27-SEP-2017, entry version 14.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|HAMAP-Rule:MF_00377, ECO:0000256|RuleBase:RU000577};
GN   Name=dnaA {ECO:0000256|HAMAP-Rule:MF_00377};
GN   ORFNames=ADL15_38110 {ECO:0000313|EMBL:KUL26505.1};
OS   Actinoplanes awajinensis subsp. mycoplanecinus.
OC   Bacteria; Actinobacteria; Micromonosporales; Micromonosporaceae;
OC   Actinoplanes.
OX   NCBI_TaxID=135947 {ECO:0000313|EMBL:KUL26505.1, ECO:0000313|Proteomes:UP000053244};
RN   [1] {ECO:0000313|EMBL:KUL26505.1, ECO:0000313|Proteomes:UP000053244}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NRRL B-16712 {ECO:0000313|EMBL:KUL26505.1,
RC   ECO:0000313|Proteomes:UP000053244};
RA   Millard Andrew;
RL   Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731907}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|SAAS:SAAS00756131}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00377, ECO:0000256|RuleBase:RU004227,
CC       ECO:0000256|SAAS:SAAS00555179}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:KUL26505.1}.
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DR   EMBL; LLZH01000306; KUL26505.1; -; Genomic_DNA.
DR   RefSeq; WP_067702007.1; NZ_LLZH01000306.1.
DR   EnsemblBacteria; KUL26505; KUL26505; ADL15_38110.
DR   Proteomes; UP000053244; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-UniRule.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-UniRule.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF12; PTHR30050:SF12; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731922};
KW   Complete proteome {ECO:0000313|Proteomes:UP000053244};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|SAAS:SAAS00756112};
KW   DNA replication {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU004227, ECO:0000256|SAAS:SAAS00731887};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00756124};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731897};
KW   Reference proteome {ECO:0000313|Proteomes:UP000053244}.
FT   DOMAIN      309    437       AAA. {ECO:0000259|SMART:SM00382}.
FT   DOMAIN      521    590       Bac_DnaA_C. {ECO:0000259|SMART:SM00760}.
FT   NP_BIND     317    324       ATP. {ECO:0000256|HAMAP-Rule:MF_00377}.
SQ   SEQUENCE   615 AA;  68956 MW;  E468D3819910CAE1 CRC64;
     MADQVDLGLL WQDTLSELSE EIASRQQRAY LRFTRLRAIV EDTALLSVPD AYTRDVIELR
     LRPAITEALT RRLNRPIQVA VTVRPPEDGS GMPGTVYGTP VESDSAPHAE PQPLHYAEPP
     RNPDPRPYQP ELPAYQPEQQ QYQQPAFGPP DRAPEPYPTG SAQHSGPPPS YIRDGSASRA
     GQEALFADPM PPQANRSAAN RTDKGPERDA PSAPNEAAVH RMPADQSQMR DNQRRQDDRR
     DDSMPMRPGD NGPGRPQVDL RGPGSSPRPG GNDGNRLNPK YMFETFVIGS SNRFAHAASV
     AVAESPAKAY NPLFIYGSSG LGKTHLLHAI GHYATTLGHA RSVRYVSTEE FTNDFINSLR
     DDKTQAFQRR YRDVDILLID DIQFLENRER TQEEFFHTFN TLHNANKQIV ISSDRSPRQL
     ATLEDRMRTR FEWGLLADIQ PPDLETRIAI LQKKAAQERM YAPADVLEFI ASRVSNSIRE
     LEGALIRVTA FASLTRATVQ LSLAEEVLRD FMPDGAGPEI TADQIMVSTA DYFGVSLEDL
     RGHSRSRVLV NARQVAMYLC RELTDLSLPR IGQAFGGRDH TTVMHADRKI RQHMAERRSL
     YNQIAELTNR IKQNT
//
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