ID A0A101JPE1_9ACTN Unreviewed; 469 AA.
AC A0A101JPE1;
DT 13-APR-2016, integrated into UniProtKB/TrEMBL.
DT 13-APR-2016, sequence version 1.
DT 24-JAN-2024, entry version 41.
DE SubName: Full=Beta-ACP synthase {ECO:0000313|EMBL:KUL30614.1};
GN ORFNames=ADL12_26350 {ECO:0000313|EMBL:KUL30614.1};
OS Streptomyces regalis.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=68262 {ECO:0000313|EMBL:KUL30614.1, ECO:0000313|Proteomes:UP000053923};
RN [1] {ECO:0000313|Proteomes:UP000053923}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NRRL 3151 {ECO:0000313|Proteomes:UP000053923};
RA Ju K.-S., Doroghazi J.R., Metcalf W.W.;
RL Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP
CC synthases family. {ECO:0000256|ARBA:ARBA00008467,
CC ECO:0000256|RuleBase:RU003694}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KUL30614.1}.
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DR EMBL; LLZG01000288; KUL30614.1; -; Genomic_DNA.
DR RefSeq; WP_062705833.1; NZ_LLZG01000288.1.
DR AlphaFoldDB; A0A101JPE1; -.
DR OrthoDB; 9808669at2; -.
DR Proteomes; UP000053923; Unassembled WGS sequence.
DR GO; GO:0004315; F:3-oxoacyl-[acyl-carrier-protein] synthase activity; IEA:InterPro.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.
DR CDD; cd00834; KAS_I_II; 1.
DR Gene3D; 3.40.47.10; -; 2.
DR InterPro; IPR000794; Beta-ketoacyl_synthase.
DR InterPro; IPR018201; Ketoacyl_synth_AS.
DR InterPro; IPR014031; Ketoacyl_synth_C.
DR InterPro; IPR014030; Ketoacyl_synth_N.
DR InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR InterPro; IPR016039; Thiolase-like.
DR PANTHER; PTHR11712:SF336; 3-OXOACYL-[ACYL-CARRIER-PROTEIN] SYNTHASE, MITOCHONDRIAL; 1.
DR PANTHER; PTHR11712; POLYKETIDE SYNTHASE-RELATED; 1.
DR Pfam; PF00109; ketoacyl-synt; 1.
DR Pfam; PF02801; Ketoacyl-synt_C; 1.
DR SMART; SM00825; PKS_KS; 1.
DR SUPFAM; SSF53901; Thiolase-like; 1.
DR PROSITE; PS00606; KS3_1; 1.
DR PROSITE; PS52004; KS3_2; 1.
PE 3: Inferred from homology;
KW Acyltransferase {ECO:0000256|ARBA:ARBA00023315};
KW Reference proteome {ECO:0000313|Proteomes:UP000053923};
KW Transferase {ECO:0000256|RuleBase:RU003694}.
FT DOMAIN 47..461
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT REGION 1..40
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 25..40
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 469 AA; 49633 MW; 87CE653400F0ACCC CRC64;
MGCGWDAAPV DPASRGSVSA FEPLSSHRAD DDDDHRTNSS KELFGLKRRV VITGVGVRAP
GGNGTRQFWE LLTSGRTATR RISFFDPSPY RSQVAAEADF DPVAEGFGPR ELDRMDRASQ
FAVACAREAV AASGLEFSAL DPTRVGVSLG SAVAAATSLE REYLLLSDSG RDWEVDAAWL
SRHMFDYLVP SVMPAEVAWA VGAEGPVAMV SNGCTSGLDS VGHAVRLIEE GSADVMLAGA
ADTPITPIVV ACFDAIRATT SRNDDPEHAS RPFDGTRDGF VLAEGAAMFV LEDYDSALAR
GAHIHAEIPG YATRCNAYHM TGLKADGREM AEAIRVALDE SRTDATDIDY INAHGSGTRQ
NDRHETAAYK RALGDHARRT PVSSIKSMVG HSLGAIGSLE IAASVLALEH GVVPPTANLH
TSDPECDLDY VPLEARERKL GTVLTVGSGF GGFQSAMVLR SAEAAGAVA
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