GenomeNet

Database: UniProt
Entry: A0A101NKE3_9ACTN
LinkDB: A0A101NKE3_9ACTN
Original site: A0A101NKE3_9ACTN 
ID   A0A101NKE3_9ACTN        Unreviewed;       632 AA.
AC   A0A101NKE3;
DT   13-APR-2016, integrated into UniProtKB/TrEMBL.
DT   13-APR-2016, sequence version 1.
DT   05-JUL-2017, entry version 13.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|HAMAP-Rule:MF_00377, ECO:0000256|RuleBase:RU000577};
GN   Name=dnaA {ECO:0000256|HAMAP-Rule:MF_00377,
GN   ECO:0000313|EMBL:KUM94916.1};
GN   ORFNames=AQI88_18920 {ECO:0000313|EMBL:KUM94916.1};
OS   Streptomyces cellostaticus.
OC   Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
OC   Streptomyces.
OX   NCBI_TaxID=67285 {ECO:0000313|EMBL:KUM94916.1, ECO:0000313|Proteomes:UP000054241};
RN   [1] {ECO:0000313|EMBL:KUM94916.1, ECO:0000313|Proteomes:UP000054241}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 40189 {ECO:0000313|EMBL:KUM94916.1,
RC   ECO:0000313|Proteomes:UP000054241};
RA   Ruckert C., Winkler A., Kalinowski J., Kampfer P., Glaeser S.;
RT   "Draft genome sequence of Streptomyces cellostaticus DSM 40189, type
RT   strain for the species Streptomyces cellostaticus.";
RL   Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731907}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|SAAS:SAAS00756131}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00377, ECO:0000256|RuleBase:RU004227,
CC       ECO:0000256|SAAS:SAAS00555179}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:KUM94916.1}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; LMWL01000034; KUM94916.1; -; Genomic_DNA.
DR   EnsemblBacteria; KUM94916; KUM94916; AQI88_18920.
DR   Proteomes; UP000054241; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-HAMAP.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-HAMAP.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-HAMAP.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-HAMAP.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF12; PTHR30050:SF12; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731922};
KW   Complete proteome {ECO:0000313|Proteomes:UP000054241};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|SAAS:SAAS00756112};
KW   DNA replication {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU004227, ECO:0000256|SAAS:SAAS00731887};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00756124};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731897};
KW   Reference proteome {ECO:0000313|Proteomes:UP000054241}.
FT   DOMAIN      325    453       AAA. {ECO:0000259|SMART:SM00382}.
FT   DOMAIN      539    608       Bac_DnaA_C. {ECO:0000259|SMART:SM00760}.
FT   NP_BIND     333    340       ATP. {ECO:0000256|HAMAP-Rule:MF_00377}.
SQ   SEQUENCE   632 AA;  70108 MW;  737B1DB7FADE437B CRC64;
     MWPRVLEQLL GEGRGQGVEV KDEHWIRRCQ PLALVADTAL LAVPNEFAKG VLEGRLAPIV
     SETLSRECGR PIRIAITVDD SAGEPSAPSA PPAQQPQPRY EEPELPSGPY EGYGRRRAGD
     QHPGGEPSSR ADQLPTARPA YPSEYQRPEP GAWPRPTQDE YGWQQPRLGF PERDPYASPS
     QDSYGSSGQD AYGSPAQDYR PQGRERPPYD QQRPEYDAPR PDYDPPRSEY DPSRTEYDQR
     DPVRRELPEP PSGVGPVHRG GPGRPDLPSA PGSGPLAAQP ASASGSGEPT ARLNPKYLFD
     TFVIGASNRF AHAAAVAVAE APAKAYNPLF IYGESGLGKT HLLHAIGHYA RSLYPGTRVR
     YVSSEEFTNE FINSIRDGKG DSFRKRYREM DILLVDDIQF LADKESTQEE FFHTFNTLHN
     ANKQIVLSSD RPPKQLVTLE DRLRNRFEWG LITDVQPPEL ETRIAILRKK AVQEQLNAPP
     EVLEFIASRI SRNIRELEGA LIRVTAFASL NRQPVDLGLT EIVLKDLIPG GEDSAPEITA
     PAIMAATADY FGLTVEDLCG TSRGRALVTA RQIAMYLCRE LTDLSLPKIG AQFGGRDHTT
     VMHADRKIRA LMAERRSIYN QVTELTNRIK NG
//
DBGET integrated database retrieval system