ID A0A101NRE7_9ACTN Unreviewed; 625 AA.
AC A0A101NRE7;
DT 13-APR-2016, integrated into UniProtKB/TrEMBL.
DT 13-APR-2016, sequence version 1.
DT 24-JAN-2024, entry version 17.
DE RecName: Full=anthranilate synthase {ECO:0000256|ARBA:ARBA00012266};
DE EC=4.1.3.27 {ECO:0000256|ARBA:ARBA00012266};
GN ORFNames=AQI88_05620 {ECO:0000313|EMBL:KUM97993.1};
OS Streptomyces cellostaticus.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=67285 {ECO:0000313|EMBL:KUM97993.1, ECO:0000313|Proteomes:UP000054241};
RN [1] {ECO:0000313|EMBL:KUM97993.1, ECO:0000313|Proteomes:UP000054241}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 40189 {ECO:0000313|EMBL:KUM97993.1,
RC ECO:0000313|Proteomes:UP000054241};
RA Ruckert C., Winkler A., Kalinowski J., Kampfer P., Glaeser S.;
RT "Draft genome sequence of Streptomyces cellostaticus DSM 40189, type strain
RT for the species Streptomyces cellostaticus.";
RL Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=chorismate + L-glutamine = anthranilate + H(+) + L-glutamate +
CC pyruvate; Xref=Rhea:RHEA:21732, ChEBI:CHEBI:15361, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:16567, ChEBI:CHEBI:29748, ChEBI:CHEBI:29985,
CC ChEBI:CHEBI:58359; EC=4.1.3.27;
CC Evidence={ECO:0000256|ARBA:ARBA00000329};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KUM97993.1}.
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DR EMBL; LMWL01000007; KUM97993.1; -; Genomic_DNA.
DR RefSeq; WP_066992774.1; NZ_KQ948016.1.
DR AlphaFoldDB; A0A101NRE7; -.
DR STRING; 67285.AQI88_05620; -.
DR OrthoDB; 8594609at2; -.
DR Proteomes; UP000054241; Unassembled WGS sequence.
DR GO; GO:0009058; P:biosynthetic process; IEA:InterPro.
DR GO; GO:0006541; P:glutamine metabolic process; IEA:UniProtKB-UniRule.
DR CDD; cd01743; GATase1_Anthranilate_Synthase; 1.
DR Gene3D; 3.40.50.880; -; 1.
DR Gene3D; 3.60.120.10; Anthranilate synthase; 1.
DR InterPro; IPR005801; ADC_synthase.
DR InterPro; IPR019999; Anth_synth_I-like.
DR InterPro; IPR015890; Chorismate_C.
DR InterPro; IPR029062; Class_I_gatase-like.
DR InterPro; IPR017926; GATASE.
DR InterPro; IPR006221; TrpG/PapA_dom.
DR PANTHER; PTHR11236; AMINOBENZOATE/ANTHRANILATE SYNTHASE; 1.
DR PANTHER; PTHR11236:SF49; ANTHRANILATE SYNTHASE COMPONENT 1; 1.
DR Pfam; PF00425; Chorismate_bind; 1.
DR Pfam; PF00117; GATase; 1.
DR PRINTS; PR00097; ANTSNTHASEII.
DR PRINTS; PR00096; GATASE.
DR SUPFAM; SSF56322; ADC synthase; 1.
DR SUPFAM; SSF52317; Class I glutamine amidotransferase-like; 1.
DR PROSITE; PS51273; GATASE_TYPE_1; 1.
PE 4: Predicted;
KW Glutamine amidotransferase {ECO:0000256|PROSITE-ProRule:PRU00605};
KW Lyase {ECO:0000256|ARBA:ARBA00023239};
KW Reference proteome {ECO:0000313|Proteomes:UP000054241}.
FT DOMAIN 108..373
FT /note="Chorismate-utilising enzyme C-terminal"
FT /evidence="ECO:0000259|Pfam:PF00425"
FT DOMAIN 433..615
FT /note="Glutamine amidotransferase"
FT /evidence="ECO:0000259|Pfam:PF00117"
FT ACT_SITE 516
FT /note="Nucleophile"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00605"
FT ACT_SITE 600
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00605"
FT ACT_SITE 602
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00605"
SQ SEQUENCE 625 AA; 67925 MW; 6FF03FFCA0F9DE17 CRC64;
MDLAQLLHDP RPFALLRRRA PGRDEHTVEV LIGPVTPRER LADLPEEGLA LVPFRQIRER
GFDVRDDGTP LLVLTPEESY EIPLAEALRS LPGHEVRVEG GGFDVGDEEY REIVGRVLRE
EIGRGEGANF VIRRTYEGEI PGFGRADALA LFRRLLEGER GAYWTFVVHT GERTLVGASP
EVHVRMSGGT VVMNPISGTY RYPAGGPTPE HLLDFLADGK EIEELSMVVD EELKMMCTVG
DMGGVVVGPR LKEMAHLAHT EYELRGKSSL DVREVLKETM FAATVTGSPV QNACRVIERH
EVGGRGYYAG ALALLGRYAG GGREESVGAQ TLDSPILIRT ADISPDGRLR VPVGATLVRG
SDPAGEVAET HAKAAGVLAA LGVRPSRPRE ERVRPRLADD PRVRAALDGR RSSLAPFWLR
MQERSGQLTG HALVVDGEDT FTAMLAHVLR SSGLDVTVRR YDEPGLREAV RVHAGPVVLG
PGPGDPSDTA DPKMQVLREL TAEVIREHRH GVLGVCLGHE LIAAELGLEI VRKEVPYQGA
QTEIDLFGRC ETVGFYNSFV ARCDDEALAE LAAHGVEVSR AGNGEVHAIR GPGFSGVQFH
PESVLSLNGA AVVRELMGQL RRTTV
//