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Database: UniProt
Entry: A0A101NUB1_9ACTN
LinkDB: A0A101NUB1_9ACTN
Original site: A0A101NUB1_9ACTN 
ID   A0A101NUB1_9ACTN        Unreviewed;       579 AA.
AC   A0A101NUB1;
DT   13-APR-2016, integrated into UniProtKB/TrEMBL.
DT   13-APR-2016, sequence version 1.
DT   24-JAN-2024, entry version 23.
DE   SubName: Full=Pyruvate dehydrogenase {ECO:0000313|EMBL:KUM99508.1};
GN   ORFNames=AQI95_39010 {ECO:0000313|EMBL:KUM99508.1};
OS   Streptomyces yokosukanensis.
OC   Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC   Streptomycetaceae; Streptomyces.
OX   NCBI_TaxID=67386 {ECO:0000313|EMBL:KUM99508.1, ECO:0000313|Proteomes:UP000053127};
RN   [1] {ECO:0000313|EMBL:KUM99508.1, ECO:0000313|Proteomes:UP000053127}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 40224 {ECO:0000313|EMBL:KUM99508.1,
RC   ECO:0000313|Proteomes:UP000053127};
RA   Ruckert C., Winkler A., Kalinowski J., Kampfer P., Glaeser S.;
RT   "Draft genome sequence of Streptomyces yokosukanensis DSM 40224, type
RT   strain for the species Streptomyces yokosukanensis.";
RL   Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the TPP enzyme family.
CC       {ECO:0000256|ARBA:ARBA00007812, ECO:0000256|RuleBase:RU362132}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KUM99508.1}.
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DR   EMBL; LMWN01000063; KUM99508.1; -; Genomic_DNA.
DR   RefSeq; WP_067135417.1; NZ_KQ948229.1.
DR   AlphaFoldDB; A0A101NUB1; -.
DR   STRING; 67386.AQI95_39010; -.
DR   OrthoDB; 4959782at2; -.
DR   Proteomes; UP000053127; Unassembled WGS sequence.
DR   GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR   GO; GO:0000287; F:magnesium ion binding; IEA:InterPro.
DR   GO; GO:0030976; F:thiamine pyrophosphate binding; IEA:InterPro.
DR   CDD; cd02014; TPP_POX; 1.
DR   CDD; cd07039; TPP_PYR_POX; 1.
DR   Gene3D; 3.40.50.970; -; 2.
DR   Gene3D; 3.40.50.1220; TPP-binding domain; 1.
DR   InterPro; IPR029035; DHS-like_NAD/FAD-binding_dom.
DR   InterPro; IPR047211; POXB-like.
DR   InterPro; IPR029061; THDP-binding.
DR   InterPro; IPR012000; Thiamin_PyroP_enz_cen_dom.
DR   InterPro; IPR012001; Thiamin_PyroP_enz_TPP-bd_dom.
DR   InterPro; IPR011766; TPP_enzyme_TPP-bd.
DR   InterPro; IPR047212; TPP_POXB-like.
DR   InterPro; IPR047210; TPP_PYR_POXB-like.
DR   PANTHER; PTHR42981; PYRUVATE DEHYDROGENASE [UBIQUINONE]; 1.
DR   PANTHER; PTHR42981:SF2; PYRUVATE DEHYDROGENASE [UBIQUINONE]; 1.
DR   Pfam; PF02775; TPP_enzyme_C; 1.
DR   Pfam; PF00205; TPP_enzyme_M; 1.
DR   Pfam; PF02776; TPP_enzyme_N; 1.
DR   SUPFAM; SSF52467; DHS-like NAD/FAD-binding domain; 1.
DR   SUPFAM; SSF52518; Thiamin diphosphate-binding fold (THDP-binding); 2.
PE   3: Inferred from homology;
KW   Pyruvate {ECO:0000313|EMBL:KUM99508.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000053127};
KW   Thiamine pyrophosphate {ECO:0000256|RuleBase:RU362132}.
FT   DOMAIN          5..116
FT                   /note="Thiamine pyrophosphate enzyme N-terminal TPP-
FT                   binding"
FT                   /evidence="ECO:0000259|Pfam:PF02776"
FT   DOMAIN          192..318
FT                   /note="Thiamine pyrophosphate enzyme central"
FT                   /evidence="ECO:0000259|Pfam:PF00205"
FT   DOMAIN          382..527
FT                   /note="Thiamine pyrophosphate enzyme TPP-binding"
FT                   /evidence="ECO:0000259|Pfam:PF02775"
SQ   SEQUENCE   579 AA;  62249 MW;  B2488AC0BDCC1100 CRC64;
     MGKRTVAQQL VDVLRQAGVS RIYGVVGDSL NPVVDAVRRT KGIEWVHVHN EEAAAFAAAA
     EAQLTGRLAV CAGSSGPGNT HLIQGLYDAH RSGAPVLALA SHIPSHQIGT NYFQETHPER
     LFAECSDYCE LVSTPDQMPR VLRIAMQRAV GHSDVSVLVL PGDLAAAAAT VPTGTSPLVS
     SAGRVTPDES QVQALADRLN SARTVMLFAG AGVRDAHAEV MRLAERLKAP IGHTLRGKEW
     IQYDNPYDVG MSGLLGYGAC FDTMQDADLV LLLGTDFPYD DFLPQQRTVQ IDHDLGRLGR
     RTVLDLGVHG DVRETLRAVL PLVRDKENRS FLDAGLRKHA QSLETVVSAY THDVDRRIPI
     HPEFPAAVLD ELADDDAVFT VDTGMCNVWA ARYITPNGRR RILGSFLHGT MANALPHAIG
     AQMADRSRQV ISMSGDGGLA MLLGELLTVK QHNLPIKTVL FNNSSLGMVK LEMLVDGLPE
     HETDHEPVDF SAIAAAVGIH AVRIERPGEV RDGLKEALAF PGPCLVELVT DANALAIPPR
     ISAEQIKGFA LAAGRTVLAG GVGQMLDVAR ANLRNIPRP
//
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