GenomeNet

Database: UniProt
Entry: A0A101P1T7_9ACTN
LinkDB: A0A101P1T7_9ACTN
Original site: A0A101P1T7_9ACTN 
ID   A0A101P1T7_9ACTN        Unreviewed;       580 AA.
AC   A0A101P1T7;
DT   13-APR-2016, integrated into UniProtKB/TrEMBL.
DT   13-APR-2016, sequence version 1.
DT   24-JAN-2024, entry version 23.
DE   SubName: Full=Pyruvate dehydrogenase {ECO:0000313|EMBL:KUN03364.1};
GN   ORFNames=AQI95_22905 {ECO:0000313|EMBL:KUN03364.1};
OS   Streptomyces yokosukanensis.
OC   Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC   Streptomycetaceae; Streptomyces.
OX   NCBI_TaxID=67386 {ECO:0000313|EMBL:KUN03364.1, ECO:0000313|Proteomes:UP000053127};
RN   [1] {ECO:0000313|EMBL:KUN03364.1, ECO:0000313|Proteomes:UP000053127}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 40224 {ECO:0000313|EMBL:KUN03364.1,
RC   ECO:0000313|Proteomes:UP000053127};
RA   Ruckert C., Winkler A., Kalinowski J., Kampfer P., Glaeser S.;
RT   "Draft genome sequence of Streptomyces yokosukanensis DSM 40224, type
RT   strain for the species Streptomyces yokosukanensis.";
RL   Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the TPP enzyme family.
CC       {ECO:0000256|ARBA:ARBA00007812, ECO:0000256|RuleBase:RU362132}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KUN03364.1}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; LMWN01000033; KUN03364.1; -; Genomic_DNA.
DR   RefSeq; WP_067126745.1; NZ_KQ948214.1.
DR   AlphaFoldDB; A0A101P1T7; -.
DR   STRING; 67386.AQI95_22905; -.
DR   OrthoDB; 4959782at2; -.
DR   Proteomes; UP000053127; Unassembled WGS sequence.
DR   GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR   GO; GO:0000287; F:magnesium ion binding; IEA:InterPro.
DR   GO; GO:0030976; F:thiamine pyrophosphate binding; IEA:InterPro.
DR   CDD; cd02014; TPP_POX; 1.
DR   CDD; cd07039; TPP_PYR_POX; 1.
DR   Gene3D; 3.40.50.970; -; 2.
DR   Gene3D; 3.40.50.1220; TPP-binding domain; 1.
DR   InterPro; IPR029035; DHS-like_NAD/FAD-binding_dom.
DR   InterPro; IPR047211; POXB-like.
DR   InterPro; IPR029061; THDP-binding.
DR   InterPro; IPR012000; Thiamin_PyroP_enz_cen_dom.
DR   InterPro; IPR012001; Thiamin_PyroP_enz_TPP-bd_dom.
DR   InterPro; IPR011766; TPP_enzyme_TPP-bd.
DR   InterPro; IPR047212; TPP_POXB-like.
DR   InterPro; IPR047210; TPP_PYR_POXB-like.
DR   PANTHER; PTHR42981; PYRUVATE DEHYDROGENASE [UBIQUINONE]; 1.
DR   PANTHER; PTHR42981:SF2; PYRUVATE DEHYDROGENASE [UBIQUINONE]; 1.
DR   Pfam; PF02775; TPP_enzyme_C; 1.
DR   Pfam; PF00205; TPP_enzyme_M; 1.
DR   Pfam; PF02776; TPP_enzyme_N; 1.
DR   SUPFAM; SSF52467; DHS-like NAD/FAD-binding domain; 1.
DR   SUPFAM; SSF52518; Thiamin diphosphate-binding fold (THDP-binding); 2.
PE   3: Inferred from homology;
KW   Pyruvate {ECO:0000313|EMBL:KUN03364.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000053127};
KW   Thiamine pyrophosphate {ECO:0000256|RuleBase:RU362132}.
FT   DOMAIN          5..116
FT                   /note="Thiamine pyrophosphate enzyme N-terminal TPP-
FT                   binding"
FT                   /evidence="ECO:0000259|Pfam:PF02776"
FT   DOMAIN          192..320
FT                   /note="Thiamine pyrophosphate enzyme central"
FT                   /evidence="ECO:0000259|Pfam:PF00205"
FT   DOMAIN          383..529
FT                   /note="Thiamine pyrophosphate enzyme TPP-binding"
FT                   /evidence="ECO:0000259|Pfam:PF02775"
SQ   SEQUENCE   580 AA;  62473 MW;  6CD8911740CB7275 CRC64;
     MAKQTIAEQY VDLMARAGVR RMYGVVGDSL NPVVDAVRRH RGVEWIQVRH EEVAAFAAGA
     EAQLTGRLAA CAGSCGPGNL HLINGLYDAH RSMAPVLALA AHIPSAEIGT GYFQETHPDR
     LFAECSHYSE LISSPRQMPR VVQTAIQHAV GRRGVSVVAL SGDTAAEDSP DAAPELAMPL
     DLPAIRPGDQ EIARLTELVD AAERVMVFCG RGVEGAHAEV MAFAEKVKAP VGHALRGKEH
     IQYDNPYDVG MSGLLGYGSA YEAMHECDLL LLLGTDFPYT DFLPRHVRTV QVDVQPERLG
     RRTGLELAVW GDVRETLRCL TPAVREKPSR RFLDRMLERH THALEGAVNA YTRDVGRHTP
     IHPEYVASVL DEEAADDAVF TVDTGMCCVW AARYLTPNGR RRILGSFVHG SMANALPQAI
     GAQFLDRGRQ VVSLSGDGGF SMLMGDFLTL VQYGLPVKVV VFDNSSLGMV DLEMMVDGLP
     PHGTTYPHTD YAAIATAAGA LGVRVEKPAE VRGALREAFA HDGPALVDVV TDPAALAVPP
     KITTEQLSGF ALSASRTVLS GGVGSMVHLA RANLRNIPRP
//
DBGET integrated database retrieval system