ID A0A101P1T7_9ACTN Unreviewed; 580 AA.
AC A0A101P1T7;
DT 13-APR-2016, integrated into UniProtKB/TrEMBL.
DT 13-APR-2016, sequence version 1.
DT 24-JAN-2024, entry version 23.
DE SubName: Full=Pyruvate dehydrogenase {ECO:0000313|EMBL:KUN03364.1};
GN ORFNames=AQI95_22905 {ECO:0000313|EMBL:KUN03364.1};
OS Streptomyces yokosukanensis.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=67386 {ECO:0000313|EMBL:KUN03364.1, ECO:0000313|Proteomes:UP000053127};
RN [1] {ECO:0000313|EMBL:KUN03364.1, ECO:0000313|Proteomes:UP000053127}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 40224 {ECO:0000313|EMBL:KUN03364.1,
RC ECO:0000313|Proteomes:UP000053127};
RA Ruckert C., Winkler A., Kalinowski J., Kampfer P., Glaeser S.;
RT "Draft genome sequence of Streptomyces yokosukanensis DSM 40224, type
RT strain for the species Streptomyces yokosukanensis.";
RL Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the TPP enzyme family.
CC {ECO:0000256|ARBA:ARBA00007812, ECO:0000256|RuleBase:RU362132}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KUN03364.1}.
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DR EMBL; LMWN01000033; KUN03364.1; -; Genomic_DNA.
DR RefSeq; WP_067126745.1; NZ_KQ948214.1.
DR AlphaFoldDB; A0A101P1T7; -.
DR STRING; 67386.AQI95_22905; -.
DR OrthoDB; 4959782at2; -.
DR Proteomes; UP000053127; Unassembled WGS sequence.
DR GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR GO; GO:0000287; F:magnesium ion binding; IEA:InterPro.
DR GO; GO:0030976; F:thiamine pyrophosphate binding; IEA:InterPro.
DR CDD; cd02014; TPP_POX; 1.
DR CDD; cd07039; TPP_PYR_POX; 1.
DR Gene3D; 3.40.50.970; -; 2.
DR Gene3D; 3.40.50.1220; TPP-binding domain; 1.
DR InterPro; IPR029035; DHS-like_NAD/FAD-binding_dom.
DR InterPro; IPR047211; POXB-like.
DR InterPro; IPR029061; THDP-binding.
DR InterPro; IPR012000; Thiamin_PyroP_enz_cen_dom.
DR InterPro; IPR012001; Thiamin_PyroP_enz_TPP-bd_dom.
DR InterPro; IPR011766; TPP_enzyme_TPP-bd.
DR InterPro; IPR047212; TPP_POXB-like.
DR InterPro; IPR047210; TPP_PYR_POXB-like.
DR PANTHER; PTHR42981; PYRUVATE DEHYDROGENASE [UBIQUINONE]; 1.
DR PANTHER; PTHR42981:SF2; PYRUVATE DEHYDROGENASE [UBIQUINONE]; 1.
DR Pfam; PF02775; TPP_enzyme_C; 1.
DR Pfam; PF00205; TPP_enzyme_M; 1.
DR Pfam; PF02776; TPP_enzyme_N; 1.
DR SUPFAM; SSF52467; DHS-like NAD/FAD-binding domain; 1.
DR SUPFAM; SSF52518; Thiamin diphosphate-binding fold (THDP-binding); 2.
PE 3: Inferred from homology;
KW Pyruvate {ECO:0000313|EMBL:KUN03364.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000053127};
KW Thiamine pyrophosphate {ECO:0000256|RuleBase:RU362132}.
FT DOMAIN 5..116
FT /note="Thiamine pyrophosphate enzyme N-terminal TPP-
FT binding"
FT /evidence="ECO:0000259|Pfam:PF02776"
FT DOMAIN 192..320
FT /note="Thiamine pyrophosphate enzyme central"
FT /evidence="ECO:0000259|Pfam:PF00205"
FT DOMAIN 383..529
FT /note="Thiamine pyrophosphate enzyme TPP-binding"
FT /evidence="ECO:0000259|Pfam:PF02775"
SQ SEQUENCE 580 AA; 62473 MW; 6CD8911740CB7275 CRC64;
MAKQTIAEQY VDLMARAGVR RMYGVVGDSL NPVVDAVRRH RGVEWIQVRH EEVAAFAAGA
EAQLTGRLAA CAGSCGPGNL HLINGLYDAH RSMAPVLALA AHIPSAEIGT GYFQETHPDR
LFAECSHYSE LISSPRQMPR VVQTAIQHAV GRRGVSVVAL SGDTAAEDSP DAAPELAMPL
DLPAIRPGDQ EIARLTELVD AAERVMVFCG RGVEGAHAEV MAFAEKVKAP VGHALRGKEH
IQYDNPYDVG MSGLLGYGSA YEAMHECDLL LLLGTDFPYT DFLPRHVRTV QVDVQPERLG
RRTGLELAVW GDVRETLRCL TPAVREKPSR RFLDRMLERH THALEGAVNA YTRDVGRHTP
IHPEYVASVL DEEAADDAVF TVDTGMCCVW AARYLTPNGR RRILGSFVHG SMANALPQAI
GAQFLDRGRQ VVSLSGDGGF SMLMGDFLTL VQYGLPVKVV VFDNSSLGMV DLEMMVDGLP
PHGTTYPHTD YAAIATAAGA LGVRVEKPAE VRGALREAFA HDGPALVDVV TDPAALAVPP
KITTEQLSGF ALSASRTVLS GGVGSMVHLA RANLRNIPRP
//