ID A0A101P7W9_9ACTN Unreviewed; 295 AA.
AC A0A101P7W9;
DT 13-APR-2016, integrated into UniProtKB/TrEMBL.
DT 13-APR-2016, sequence version 1.
DT 24-JAN-2024, entry version 29.
DE SubName: Full=3-hydroxyisobutyrate dehydrogenase {ECO:0000313|EMBL:KUN06605.1};
GN ORFNames=AQI95_12030 {ECO:0000313|EMBL:KUN06605.1};
OS Streptomyces yokosukanensis.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=67386 {ECO:0000313|EMBL:KUN06605.1, ECO:0000313|Proteomes:UP000053127};
RN [1] {ECO:0000313|EMBL:KUN06605.1, ECO:0000313|Proteomes:UP000053127}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 40224 {ECO:0000313|EMBL:KUN06605.1,
RC ECO:0000313|Proteomes:UP000053127};
RA Ruckert C., Winkler A., Kalinowski J., Kampfer P., Glaeser S.;
RT "Draft genome sequence of Streptomyces yokosukanensis DSM 40224, type
RT strain for the species Streptomyces yokosukanensis.";
RL Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the HIBADH-related family.
CC {ECO:0000256|ARBA:ARBA00009080}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KUN06605.1}.
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DR EMBL; LMWN01000016; KUN06605.1; -; Genomic_DNA.
DR RefSeq; WP_067121226.1; NZ_KQ948209.1.
DR AlphaFoldDB; A0A101P7W9; -.
DR STRING; 67386.AQI95_12030; -.
DR OrthoDB; 3185659at2; -.
DR Proteomes; UP000053127; Unassembled WGS sequence.
DR GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR GO; GO:0050661; F:NADP binding; IEA:InterPro.
DR GO; GO:0016616; F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; IEA:UniProt.
DR GO; GO:0016054; P:organic acid catabolic process; IEA:UniProt.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR InterPro; IPR013328; 6PGD_dom2.
DR InterPro; IPR006115; 6PGDH_NADP-bd.
DR InterPro; IPR029154; HIBADH-like_NADP-bd.
DR InterPro; IPR015815; HIBADH-related.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR43580; OXIDOREDUCTASE GLYR1-RELATED; 1.
DR PANTHER; PTHR43580:SF2; OXIDOREDUCTASE GLYR1-RELATED; 1.
DR Pfam; PF14833; NAD_binding_11; 1.
DR Pfam; PF03446; NAD_binding_2; 1.
DR PIRSF; PIRSF000103; HIBADH; 1.
DR SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 3: Inferred from homology;
KW NAD {ECO:0000256|ARBA:ARBA00023027};
KW Reference proteome {ECO:0000313|Proteomes:UP000053127}.
FT DOMAIN 7..162
FT /note="6-phosphogluconate dehydrogenase NADP-binding"
FT /evidence="ECO:0000259|Pfam:PF03446"
FT DOMAIN 168..286
FT /note="3-hydroxyisobutyrate dehydrogenase-like NAD-binding"
FT /evidence="ECO:0000259|Pfam:PF14833"
FT ACT_SITE 174
FT /evidence="ECO:0000256|PIRSR:PIRSR000103-1"
SQ SEQUENCE 295 AA; 30534 MW; 28672E218040331B CRC64;
MTGKPTVSVL GTGIMGAAMA RNLARAGLEV RAWNRTREKA EPLAADGIRV TGTPTEAVDG
ADAVLTMLYD GNTVLDVMRE AAPALRPGTV WAQCTTAGID LVADLAAFAR EHGLVFYDAP
VLGTRQPAEA GQLTVLAAGP EEGRKTVTPV FDAVGAKTVW TGEDGAAGSA SRLKLVANSW
VLAVTAATGE VLALSKGLGV DPQSFFDLIR SGPLDMGYLR AKAALVLDDK LTPASFAVAT
AEKDARLIVE AGERGGVRLD VAEAAAERFA RAAAHGHADE DMAAAYFASF DAKGR
//