ID A0A101R2X5_9ACTN Unreviewed; 704 AA.
AC A0A101R2X5;
DT 13-APR-2016, integrated into UniProtKB/TrEMBL.
DT 13-APR-2016, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE RecName: Full=SSD domain-containing protein {ECO:0000259|PROSITE:PS50156};
GN ORFNames=AQJ30_04770 {ECO:0000313|EMBL:KUN40682.1};
OS Streptomyces longwoodensis.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=68231 {ECO:0000313|EMBL:KUN40682.1, ECO:0000313|Proteomes:UP000053271};
RN [1] {ECO:0000313|EMBL:KUN40682.1, ECO:0000313|Proteomes:UP000053271}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 41677 {ECO:0000313|EMBL:KUN40682.1,
RC ECO:0000313|Proteomes:UP000053271};
RA Ruckert C., Winkler A., Kalinowski J., Kampfer P., Glaeser S.;
RT "Draft genome sequence of Streptomyces longwoodensis DSM 41677, type strain
RT for the species Streptomyces longwoodensis.";
RL Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the resistance-nodulation-cell division (RND)
CC (TC 2.A.6) family. MmpL subfamily. {ECO:0000256|ARBA:ARBA00010157}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KUN40682.1}.
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DR EMBL; LMWS01000007; KUN40682.1; -; Genomic_DNA.
DR RefSeq; WP_067228744.1; NZ_KQ948549.1.
DR AlphaFoldDB; A0A101R2X5; -.
DR STRING; 68231.AQJ30_04770; -.
DR Proteomes; UP000053271; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR InterPro; IPR004869; MMPL_dom.
DR InterPro; IPR000731; SSD.
DR PANTHER; PTHR33406; MEMBRANE PROTEIN MJ1562-RELATED; 1.
DR PANTHER; PTHR33406:SF6; MEMBRANE PROTEIN SCO0839-RELATED; 1.
DR Pfam; PF03176; MMPL; 2.
DR SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR PROSITE; PS50156; SSD; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000053271};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 176..196
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 203..223
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 235..255
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 275..300
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 312..334
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 369..389
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 510..527
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 534..555
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 567..586
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 614..635
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 641..662
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 215..333
FT /note="SSD"
FT /evidence="ECO:0000259|PROSITE:PS50156"
FT REGION 679..704
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 704 AA; 73188 MW; 068CF91984C8A4EB CRC64;
MTVGKTPTKG VGRRRAVPWA LLGLWVAVLA LVGPFAAKLA DVQHDRATDY LPSSADSTQV
ARIQDALPGG ESTEMVIVYH RDGGLSAEDR RVAAGQVGKV AAAHELVGGA PEGIPSDDGT
TLMYPVVSNE PGHDEKLRDA LVEDVRGIAR GQDGLSVEVG GTGALGTDAG KVYDSLGGPL
LYTTVAVVAL LLILIYRSPV LWLVPLVVAG IADYLSMGVA YGLNQAFGTT VTGQSSGVMT
ILVFGAGTDY ALLLVSRYRE ELRRIERPYE AMVAALRGCG PAVLASSGTV AAGLLCLLAA
DLNSSRGMGP LGTVGVLCAL IAMLTLLPAV LVLLGRRVFW PLVPAYGSEP AQRRSLFAAM
GDSAGRRPLT VLATGAVLLG ALALGTLNLP GPVKQEDSFV TKPESVTAME TLARAYPERG
TQPIDVITPA DRVDRTLATI RGTRGVESAE KGRTADGWAE VSVIAKDTPQ SAGETATIKS
LRSQLKGSYV GGDSAEQIDL EDTNSRDIKI VVPLVLVSVL LILFVLLRSL VAPLVLVAAV
VAVWGAALGI GGLVFGPVLG LKGTDPGLGL LSFVFLVALG VDYGIFLMHR MREESLAGAE
PAAAALTALR STGAVIASAG LVLAATFAVL MNMGLVQLVE LGFVIAVGVL LDTFLVRTYL
VTSASVALRR KMWWPGGLSR EPARGAGPSE PTEPPRQPEQ VGTP
//
