ID A0A101SL58_9ACTN Unreviewed; 593 AA.
AC A0A101SL58;
DT 13-APR-2016, integrated into UniProtKB/TrEMBL.
DT 13-APR-2016, sequence version 1.
DT 27-MAR-2024, entry version 44.
DE SubName: Full=Serine protease {ECO:0000313|EMBL:KUN75722.1};
GN ORFNames=AQJ64_41375 {ECO:0000313|EMBL:KUN75722.1};
OS Streptomyces griseoruber.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1943 {ECO:0000313|EMBL:KUN75722.1, ECO:0000313|Proteomes:UP000052982};
RN [1] {ECO:0000313|EMBL:KUN75722.1, ECO:0000313|Proteomes:UP000052982}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 40281 {ECO:0000313|EMBL:KUN75722.1,
RC ECO:0000313|Proteomes:UP000052982};
RA Ruckert C., Winkler A., Kalinowski J., Kampfer P., Glaeser S.;
RT "Draft genome sequence of Streptomyces griseoruber DSM 40281, type strain
RT for the species Streptomyces griseoruber.";
RL Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the peptidase S1 family.
CC {ECO:0000256|ARBA:ARBA00007664}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KUN75722.1}.
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DR EMBL; LMWW01000074; KUN75722.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A101SL58; -.
DR STRING; 1943.AQJ64_41375; -.
DR OrthoDB; 1496095at2; -.
DR Proteomes; UP000052982; Unassembled WGS sequence.
DR GO; GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd00190; Tryp_SPc; 1.
DR Gene3D; 2.130.10.130; Integrin alpha, N-terminal; 1.
DR Gene3D; 2.40.10.10; Trypsin-like serine proteases; 1.
DR InterPro; IPR013517; FG-GAP.
DR InterPro; IPR028994; Integrin_alpha_N.
DR InterPro; IPR009003; Peptidase_S1_PA.
DR InterPro; IPR043504; Peptidase_S1_PA_chymotrypsin.
DR InterPro; IPR001314; Peptidase_S1A.
DR InterPro; IPR001254; Trypsin_dom.
DR InterPro; IPR018114; TRYPSIN_HIS.
DR InterPro; IPR033116; TRYPSIN_SER.
DR PANTHER; PTHR24276:SF91; AT26814P-RELATED; 1.
DR PANTHER; PTHR24276; POLYSERASE-RELATED; 1.
DR Pfam; PF13517; FG-GAP_3; 1.
DR Pfam; PF00089; Trypsin; 1.
DR PRINTS; PR00722; CHYMOTRYPSIN.
DR SMART; SM00020; Tryp_SPc; 1.
DR SUPFAM; SSF69318; Integrin alpha N-terminal domain; 1.
DR SUPFAM; SSF50494; Trypsin-like serine proteases; 1.
DR PROSITE; PS50240; TRYPSIN_DOM; 1.
DR PROSITE; PS00134; TRYPSIN_HIS; 1.
DR PROSITE; PS00135; TRYPSIN_SER; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Hydrolase {ECO:0000256|RuleBase:RU363034};
KW Protease {ECO:0000256|RuleBase:RU363034, ECO:0000313|EMBL:KUN75722.1};
KW Serine protease {ECO:0000256|RuleBase:RU363034};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..27
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 28..593
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5007106329"
FT DOMAIN 80..399
FT /note="Peptidase S1"
FT /evidence="ECO:0000259|PROSITE:PS50240"
FT REGION 51..81
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 55..81
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 593 AA; 61579 MW; 660764733D06A571 CRC64;
MRIALPVAAA GLAAAVAGVF VTTSAGAATA APTPVRSTPS TSEIEARLST ALAGDDTAGE
TSKSSLGASS SSSTSVDPKI IGGSTTTITT APYMAQLWYG DNRGTSTTSD DIGFFCGGAV
VAPTKILTAA HCVAGYNWKA HGVVVTGTAQ LLSEDSSGNP DLHGGNPSGV WRQWNHPSYD
DNTIDNDLAV LTLPNPVKAT PIPMTTAGDT ASYTGAAAKT AQVFGWGRTS STSQDISDTL
KTATLPIQSD ATCSAEYGSD FIAGHMVCAG EPATGSDTGT TSACNGDSGG PLVVGGKVVG
VVSWGVKDCV AAGAYSVFTK LTTYVAAAYP RIDDTNLSGD HKADLFVRNS STKTGYEIDS
KGTSLASRLS WGSHSAWNLV LQTDLDRDGY TDFIRRRASD GDLYWRHCVF PSNGTTCTWT
NTLVGDNWKS RLAVVVPGDV TGDKLPDLLS VDSAGVLWIY PGKGNGRFAT RVKVSTGWNQ
YNVVRGHGDL SNDGRADLLA RNKSTGAVYL YKGTGKAGTG AFSARVKVRT WSGTTYNAFD
AVGDVNGDGK ADFLARTPGG TLYLYKGTGK ATSEIFATRV SLGTSFKQYD LFG
//
