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Database: UniProt
Entry: A0A101V2R1_9ACTN
LinkDB: A0A101V2R1_9ACTN
Original site: A0A101V2R1_9ACTN 
ID   A0A101V2R1_9ACTN        Unreviewed;       614 AA.
AC   A0A101V2R1;
DT   13-APR-2016, integrated into UniProtKB/TrEMBL.
DT   13-APR-2016, sequence version 1.
DT   25-OCT-2017, entry version 15.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|HAMAP-Rule:MF_00377, ECO:0000256|RuleBase:RU000577};
GN   Name=dnaA {ECO:0000256|HAMAP-Rule:MF_00377,
GN   ECO:0000313|EMBL:KUO21445.1};
GN   ORFNames=AQJ91_08895 {ECO:0000313|EMBL:KUO21445.1};
OS   Streptomyces sp. RV15.
OC   Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
OC   Streptomyces.
OX   NCBI_TaxID=909626 {ECO:0000313|EMBL:KUO21445.1, ECO:0000313|Proteomes:UP000053260};
RN   [1] {ECO:0000313|EMBL:KUO21445.1, ECO:0000313|Proteomes:UP000053260}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=RV15 {ECO:0000313|EMBL:KUO21445.1,
RC   ECO:0000313|Proteomes:UP000053260};
RA   Ruckert C., Abdelmohsen U.R., Winkler A., Hentschel U., Kalinowski J.,
RA   Kampfer P., Glaeser S.;
RT   "Draft genome sequence of Streptomyces sp. RV15, isolated from a
RT   marine sponge.";
RL   Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00735475}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|SAAS:SAAS00911680}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00377, ECO:0000256|RuleBase:RU004227,
CC       ECO:0000256|SAAS:SAAS00555179}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:KUO21445.1}.
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DR   EMBL; LMXB01000024; KUO21445.1; -; Genomic_DNA.
DR   EnsemblBacteria; KUO21445; KUO21445; AQJ91_08895.
DR   Proteomes; UP000053260; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-UniRule.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-UniRule.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF2; PTHR30050:SF2; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00747950};
KW   Complete proteome {ECO:0000313|Proteomes:UP000053260};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|SAAS:SAAS00911664};
KW   DNA replication {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU004227, ECO:0000256|SAAS:SAAS00747996};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00911684};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00747895};
KW   Reference proteome {ECO:0000313|Proteomes:UP000053260}.
FT   DOMAIN      307    435       AAA. {ECO:0000259|SMART:SM00382}.
FT   DOMAIN      521    590       Bac_DnaA_C. {ECO:0000259|SMART:SM00760}.
FT   NP_BIND     315    322       ATP. {ECO:0000256|HAMAP-Rule:MF_00377}.
SQ   SEQUENCE   614 AA;  68715 MW;  512912F91AD51A34 CRC64;
     MWPRVLEQLL GEGRGQGVEG KDEHWIRRCQ PLALVADTAL LAVPNEFAKG VLEGRLAPIV
     SDTLSRECGR PIRIAITVDD SAGEPPAPPA PPTQQRQQRY EEPELPSYES YGRHRADDRQ
     QHGPGDQLPT ARPTYPSEYQ RPEPGGWPRP QQDDYSWQQQ RLGFPERDPY ASPSEDSYSR
     DPYGPPQDYR PQSMERPSYD SQRGDYDQQR PDYDKPRSDY DQRDARRDLP EASSGSGHVH
     RGGPVGSVLP TTGAPGPLAA QPAPATGPGE PTARLNPKYL FDTFVIGASN RFAHAAAVAV
     AEAPAKAYNP LFIYGESGLG KTHLLHAIGH YARSLYPGTR VRYVSSEEFT NEFINSIRDG
     KGDSFRKRYR EMDILLVDDI QFLADKESTQ EEFFHTFNTL HNANKQIVLS SDRPPRQLVT
     LEDRLRNRFE WGLTTDVQPP ELETRIAILR KKAVQEQLNA PPEVLEFIAS RISRNIRELE
     GALIRVTAFA SLNRQPVDLG LTEIVLKDLI PGGEDSAPEI TSTAIMSATA DYFGLTVEDL
     CGTSRGRALV TARQIAMYLC RELTDLSLPK IGALFGGRDH TTVMHADRKI RNLMAERRSI
     YNQVTELTNR IKNG
//
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