ID   A0A101XCJ0_9CREN        Unreviewed;       823 AA.
AC   A0A101XCJ0;
DT   13-APR-2016, integrated into UniProtKB/TrEMBL.
DT   13-APR-2016, sequence version 1.
DT   27-MAR-2024, entry version 31.
DE   SubName: Full=Aminopeptidase {ECO:0000313|EMBL:KUO88874.1};
GN   ORFNames=AT715_02275 {ECO:0000313|EMBL:KUO88874.1};
OS   Thermoproteus sp. JCHS_4.
OC   Archaea; Thermoproteota; Thermoprotei; Thermoproteales; Thermoproteaceae;
OC   Thermoproteus.
OX   NCBI_TaxID=1714258 {ECO:0000313|EMBL:KUO88874.1, ECO:0000313|Proteomes:UP000054781};
RN   [1] {ECO:0000313|EMBL:KUO88874.1, ECO:0000313|Proteomes:UP000054781}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Jay Z.J., Beam J.P., Kozubal M.A., Jennings R.D.E., Rusch D.B.,
RA   Inskeep W.P.;
RT   "The distribution, diversity and function of predominant Thermoproteales in
RT   high-temperature environments of Yellowstone National Park.";
RL   Submitted (DEC-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC         Evidence={ECO:0000256|ARBA:ARBA00001947};
CC   -!- SIMILARITY: Belongs to the peptidase M1 family.
CC       {ECO:0000256|ARBA:ARBA00010136}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:KUO88874.1}.
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DR   EMBL; LOBZ01000001; KUO88874.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A101XCJ0; -.
DR   STRING; 1714258.AT715_02275; -.
DR   Proteomes; UP000054781; Unassembled WGS sequence.
DR   GO; GO:0004177; F:aminopeptidase activity; IEA:UniProtKB-KW.
DR   GO; GO:0008237; F:metallopeptidase activity; IEA:UniProtKB-KW.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   CDD; cd09603; M1_APN_like; 1.
DR   Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 2.
DR   Gene3D; 1.10.390.10; Neutral Protease Domain 2; 1.
DR   Gene3D; 2.60.40.1730; tricorn interacting facor f3 domain; 1.
DR   InterPro; IPR045357; Aminopeptidase_N-like_N.
DR   InterPro; IPR042097; Aminopeptidase_N-like_N_sf.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR004155; PBS_lyase_HEAT.
DR   InterPro; IPR001930; Peptidase_M1.
DR   InterPro; IPR014782; Peptidase_M1_dom.
DR   InterPro; IPR027268; Peptidase_M4/M1_CTD_sf.
DR   PANTHER; PTHR11533:SF303; AMINOPEPTIDASE N; 1.
DR   PANTHER; PTHR11533; PROTEASE M1 ZINC METALLOPROTEASE; 1.
DR   Pfam; PF13646; HEAT_2; 2.
DR   Pfam; PF01433; Peptidase_M1; 1.
DR   Pfam; PF17900; Peptidase_M1_N; 1.
DR   PRINTS; PR00756; ALADIPTASE.
DR   SMART; SM00567; EZ_HEAT; 5.
DR   SUPFAM; SSF48371; ARM repeat; 2.
DR   SUPFAM; SSF63737; Leukotriene A4 hydrolase N-terminal domain; 1.
DR   SUPFAM; SSF55486; Metalloproteases ('zincins'), catalytic domain; 1.
PE   3: Inferred from homology;
KW   Aminopeptidase {ECO:0000313|EMBL:KUO88874.1};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Metalloprotease {ECO:0000256|ARBA:ARBA00023049};
KW   Protease {ECO:0000256|ARBA:ARBA00022670};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT   DOMAIN          21..192
FT                   /note="Aminopeptidase N-like N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF17900"
FT   DOMAIN          226..446
FT                   /note="Peptidase M1 membrane alanine aminopeptidase"
FT                   /evidence="ECO:0000259|Pfam:PF01433"
FT   COILED          790..821
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   823 AA;  94979 MW;  21FAAC7DE4E0AE57 CRC64;
     MARYLVGRDF AFPEYVPRFP RQYDFDVVKL DLDVELDLWN REVRGVARYR VRAKRDLRKL
     ALDAAELEVL GASTGYSYDG ESISLDLNLP AGREAEFEVR YRARPRKGIY FVLPDRHHPY
     RVPMAWTQGE SEDNRYWIPL PDTPNIKFPW RLSITVPKPY VAGSNGVLVE VRDGGDKQTF
     VWEMRHPMSP YLIALAAGDF EIARDKCGNV ELEYWLPKGR AGVAQYSFKN TCNIMKFFEE
     YLGVPYPYER YAQVVVQEFV YGGMENTTFT ILTDWTLHDK HAHCPYEDFP CLQEDFSSDP
     LVAHEMAHQW FGDLVTAKDW GHISINESFA TFIEALWTER SKGRDEYLYE MYLNLRAYLN
     EYSTRYARPI VTNLYAIPEE VFDRHSYEKG SVVLHTIRSL LGDEAFRRGL KLFLERHRYR
     NADIEDLRKA LEEASGMDLE WLWRQFFYSA GHPVVKASWS KNNGVRLVLE QAQPDDSFPV
     YTLPLEIEVA YEDGRRDKIS VSFSEKRLEV PLGEKARYAC IDPDFKLLKV VELNFPVEAL
     GAMLDDANLY CRLQAVEALR RNGSNRAVEF LAKALRDKFW GVAAEAARAL GAIGTADSVK
     ALMEAYRDVR HPRARRAVME ALGNARRREA AEFLDRVLHD GSESYYVRYE AAKALGKTKW
     EFAEYSLRKA LGYGGHMDVV TRGAIEGLAE LGSDGALEVV LAHAGEDKPT WIRMTAVQSL
     SKFGPRPQVL EALRRALRDD NYRIRAAAVT AALDLMDARL MPDLQERAER DVDGRIRRMA
     REAAEKIKRA MDRGAEYQKL REEVEKLRDE YRKLLDRLSR LER
//