ID A0A109FDY7_9BASI Unreviewed; 822 AA.
AC A0A109FDY7;
DT 13-APR-2016, integrated into UniProtKB/TrEMBL.
DT 13-APR-2016, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=DNase I-like protein {ECO:0000313|EMBL:KWU42743.1};
GN ORFNames=RHOSPDRAFT_35691 {ECO:0000313|EMBL:KWU42743.1};
OS Rhodotorula sp. JG-1b.
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Pucciniomycotina;
OC Microbotryomycetes; Sporidiobolales; Sporidiobolaceae; Rhodotorula.
OX NCBI_TaxID=1305733 {ECO:0000313|EMBL:KWU42743.1, ECO:0000313|Proteomes:UP000062823};
RN [1] {ECO:0000313|EMBL:KWU42743.1, ECO:0000313|Proteomes:UP000062823}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JG-1b {ECO:0000313|EMBL:KWU42743.1,
RC ECO:0000313|Proteomes:UP000062823};
RG DOE Joint Genome Institute;
RA Goordial J., Raymond-Bouchard I., Riley R., Ronholm J., Shapiro N.,
RA Woyke T., Grigoriev I.V., Labutti K.M., Greer C., Whyte L., Bakermans C.;
RT "Draft genome of eurypsychrophile Rhodotorula sp. JG1b isolated from
RT permafrost in the hyper-arid Upper Elevation McMurdo Dry Valleys,
RT Antarctica.";
RL Submitted (DEC-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle, phagosome membrane
CC {ECO:0000256|ARBA:ARBA00004580}. Early endosome membrane
CC {ECO:0000256|ARBA:ARBA00004146}. Endosome membrane
CC {ECO:0000256|ARBA:ARBA00004608}. Membrane
CC {ECO:0000256|ARBA:ARBA00004370}.
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DR EMBL; KQ954501; KWU42743.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A109FDY7; -.
DR STRING; 1305733.A0A109FDY7; -.
DR OrthoDB; 996872at2759; -.
DR Proteomes; UP000062823; Unassembled WGS sequence.
DR GO; GO:0031901; C:early endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0030670; C:phagocytic vesicle membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProt.
DR GO; GO:0004439; F:phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity; IEA:UniProt.
DR GO; GO:0046856; P:phosphatidylinositol dephosphorylation; IEA:InterPro.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR Gene3D; 3.60.10.10; Endonuclease/exonuclease/phosphatase; 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR InterPro; IPR036691; Endo/exonu/phosph_ase_sf.
DR InterPro; IPR046985; IP5.
DR InterPro; IPR000300; IPPc.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR PANTHER; PTHR11200; INOSITOL 5-PHOSPHATASE; 1.
DR PANTHER; PTHR11200:SF299; PHOSPHOINOSITIDE 5-PHOSPHATASE; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR SMART; SM00128; IPPc; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SUPFAM; SSF56219; DNase I-like; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR PROSITE; PS50238; RHOGAP; 1.
PE 4: Predicted;
KW Cytoplasmic vesicle {ECO:0000256|ARBA:ARBA00023329};
KW Endosome {ECO:0000256|ARBA:ARBA00022753};
KW Reference proteome {ECO:0000313|Proteomes:UP000062823}.
FT DOMAIN 626..821
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT REGION 1..46
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 597..620
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 650..679
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 774..802
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 13..27
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 31..46
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 822 AA; 90271 MW; 74CE831DF9F06924 CRC64;
MVSKPDDVAA SSVEQRRQAS TRQRVASILS HDDAGGDDGR SHGRDPSWER RALRSWLGEE
LDRRTADFSR REEIRVWCGT YNVNDKSPRS ADNIQDWVQS CGNAELLVFS FQEFDLSTEA
MFRYTSYRED LWRAAIEQAL SNQGAQSYTK LHSRQLVGGL ILVYVRSDIA ENVSAVTSTS
LATGLMGVMA NKGAVAVRLK YHDTPLTFVN SHLAAFVPNS AERNAQFRTT TSQLLFPLSN
DGSDQRDEWS SCLRPDEARP AGAGASVWDC DGLFWMGDLN YRLDATREDI DALIRRGDHQ
ALLAFDQLAI QQQLRLVFEG FEEGELDFPP TFKFDAGTDD YDTSEKQRAP AYTDRIVYLA
CPHCPIVVER YNSHPAVLLS DHKPVSATLR LPVRRVDRMK RQQIAEDLVA SLDAVPTGLE
EPEPAEVELI PGPELKFAGL EHGSSATLTL DLRNCGEEQG VGDHSGPVLS DLLILSVRGR
DLFLAVSLES WIPTVLGAPL DHLVQLRKPI RETTLSDRAA IGRSTLNGLD AGSKDDAATP
ATATAETIPL VIRRLVAFLA ESGLGLPDLF QAQVEEENVR VILRCLDTAS RGDTFAQVSS
FDQDQQPRVD SSEGDKSDKQ HLVDAVDLLD KLETDLGSVS LDFGPREHLE PALPLSGSNR
DAASSGLTGG GGGGGGGRET TPATAYAAAA CLVRILKALP EPVVETRLYE AAIRSDSREA
AYEVLHSLKE VHANTLLYLV AFLRILLRQQ TSAAERAYLL LQLALTFSKV LLRPPSRPPR
DDEEGYQLSE NYAPDGIDPG SVPRRAKEFV AFLLQEEEPQ AA
//
